Abnormal Mitochondrial Morphology in Sporadic Parkinson's and Alzheimer's Disease Cybrid Cell Lines

Diseases linked to defective mitochondrial function are characterized by morphologically abnormal, swollen mitochondria with distorted cristae. Several lines of evidence now suggest that sporadic forms of Parkinson's disease (PD) and Alzheimer's disease (AD) are linked to mitochondrial dys...

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Veröffentlicht in:	Experimental neurology 2000-03, Vol.162 (1), p.37-50
Hauptverfasser:	Trimmer, Patricia A., Swerdlow, Russell H., Parks, Janice K., Keeney, Paula, Bennett, James P., Miller, Scott W., Davis, Robert E., Parker, W.Davis
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - pathology Alzheimer's disease Benzimidazoles Carbocyanines cybid cells cybrid electron microscopy Electron Transport Complex I Female Fluorescent Dyes Humans Hybrid Cells Inclusion Bodies - pathology Inclusion Bodies - ultrastructure Male Microscopy, Confocal Microscopy, Electron Middle Aged mitochondria Mitochondria - enzymology Mitochondria - pathology Mitochondria - ultrastructure mitochondrial inclusions NADH, NADPH Oxidoreductases - metabolism Neuroblastoma Organic Chemicals Parkinson Disease - pathology Parkinson's disease
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