Postnatal androgenization induces premature aging of rat ovaries

In the present paper, we report that ovaries of adult rats treated with testosterone propionate (TP) on a critical postnatal Day 5 exhibit histologic and immunohistochemical findings which resemble those of the anovulatory ovaries in middle-aged female rats. The sterile rat model has been long known...

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Veröffentlicht in:	Steroids 2000-04, Vol.65 (4), p.190-205
Hauptverfasser:	Bukovskya, Antonin, Ayala, Maria E, Dominguez, Roberto, Keenan, Jeffrey A, Wimalasena, Jay, McKenzie, Pamela P, Caudle, Michael R
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Androgens - metabolism Androgens - pharmacology Animals Animals, Newborn Anovulation Biological and medical sciences Cellular aging Cellular Senescence - physiology Dendritic Cells - drug effects Female Fundamental and applied biological sciences. Psychology Immune adaptation Mammalian female genital system Mesenchymal cells Mesoderm - cytology Mesoderm - drug effects Morphology. Physiology Ontogeny Ovarian steroidogenic cells Ovary - cytology Ovary - drug effects Ovary - physiology Pericytes - cytology Pericytes - drug effects Rats Rats, Inbred Strains Receptors, LH - metabolism T-Lymphocytes - cytology T-Lymphocytes - drug effects Testosterone - pharmacology Vacuoles Vertebrates: reproduction
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