A bihormonal model of normal sexual stimulation; the etiology of premature ejaculation
The physiological sexual excitation is mediated both by the sympathetic and the parasympathetic nervous system. The antagonism between testosterone (Tt) and estrogens (Es) as well as the fact that the dynamics of the sexual excitation in the male are antagonistic to those in the female are nowadays...
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Veröffentlicht in: | Medical hypotheses 2001-07, Vol.57 (1), p.93-95 |
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description | The physiological sexual excitation is mediated both by the sympathetic and the parasympathetic nervous system. The antagonism between testosterone (Tt) and estrogens (Es) as well as the fact that the dynamics of the sexual excitation in the male are antagonistic to those in the female are nowadays well-known; hence, the hypothesis was emitted that the sympathoparasympathetic sexual excitation is bihormonal mediated, consisting in a very active sexual hormone associated with a weak antagonistic hormone.
Most studies show a serotonergic (ejaculatory) involvement in premature ejaculation (PE). Nevertheless, an effective treatment of PE is rather difficult with selective serotonin reuptake inhibitor drugs and other clinical data even suggest that changes in PE actually involve at first the sexual excitation process and only secondly the ejaculation reflex.
Thus, a therapeutic model for PE is set up, starting from the physiological aspects described and from the presumed pathophysiological mechanism in PE. |
doi_str_mv | 10.1054/mehy.2001.1296 |
format | Article |
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Most studies show a serotonergic (ejaculatory) involvement in premature ejaculation (PE). Nevertheless, an effective treatment of PE is rather difficult with selective serotonin reuptake inhibitor drugs and other clinical data even suggest that changes in PE actually involve at first the sexual excitation process and only secondly the ejaculation reflex.
Thus, a therapeutic model for PE is set up, starting from the physiological aspects described and from the presumed pathophysiological mechanism in PE.</description><identifier>ISSN: 0306-9877</identifier><identifier>EISSN: 1532-2777</identifier><identifier>DOI: 10.1054/mehy.2001.1296</identifier><identifier>PMID: 11421633</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Ejaculation ; Estrogens - physiology ; Gynecology. Andrology. Obstetrics ; Humans ; Male ; Male genital diseases ; Medical sciences ; Models, Biological ; Non tumoral diseases ; Serotonin - physiology ; Testosterone - physiology</subject><ispartof>Medical hypotheses, 2001-07, Vol.57 (1), p.93-95</ispartof><rights>2001 Harcourt Publishers Ltd</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2001 Harcourt Publishers Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-c35f43982f7ff75657b98f67e01361954471f075b8be90fe6bca7b1f41cd50193</citedby><cites>FETCH-LOGICAL-c369t-c35f43982f7ff75657b98f67e01361954471f075b8be90fe6bca7b1f41cd50193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1054/mehy.2001.1296$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1044684$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11421633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Motofei, I.G.</creatorcontrib><title>A bihormonal model of normal sexual stimulation; the etiology of premature ejaculation</title><title>Medical hypotheses</title><addtitle>Med Hypotheses</addtitle><description>The physiological sexual excitation is mediated both by the sympathetic and the parasympathetic nervous system. The antagonism between testosterone (Tt) and estrogens (Es) as well as the fact that the dynamics of the sexual excitation in the male are antagonistic to those in the female are nowadays well-known; hence, the hypothesis was emitted that the sympathoparasympathetic sexual excitation is bihormonal mediated, consisting in a very active sexual hormone associated with a weak antagonistic hormone.
Most studies show a serotonergic (ejaculatory) involvement in premature ejaculation (PE). Nevertheless, an effective treatment of PE is rather difficult with selective serotonin reuptake inhibitor drugs and other clinical data even suggest that changes in PE actually involve at first the sexual excitation process and only secondly the ejaculation reflex.
Thus, a therapeutic model for PE is set up, starting from the physiological aspects described and from the presumed pathophysiological mechanism in PE.</description><subject>Biological and medical sciences</subject><subject>Ejaculation</subject><subject>Estrogens - physiology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Non tumoral diseases</subject><subject>Serotonin - physiology</subject><subject>Testosterone - physiology</subject><issn>0306-9877</issn><issn>1532-2777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9L5DAUx4O46Dh69Sg9yN5mNml-NXgScVUQ9rLrNaTpi5OhbcakFee_35Qp6MVLXt7j8748PghdErwmmLNfHWz26xJjsialEkdoQTgtV6WU8hgtMMVipSopT9FZSluMsWK0OkGnhLCSCEoX6OW2qP0mxC70pi260EBbBFf0eZL7BB_jVAbfja0ZfOhvimEDBeRvG173E7qL0JlhjHm6NXbGztEPZ9oEF3Ndon-_7__ePa6e_zw83d0-rywVasgvd4yqqnTSOckFl7WqnJCACRVEccYkcVjyuqpBYQeitkbWxDFiG46Jokv085C7i-FthDTozicLbWt6CGPSEivBs5kMrg-gjSGlCE7vou9M3GuC9WRSTyb1ZFJPJvPC1Zw81h00n_isLgPXM2CSNa2Lprc-fYllTFQsY9UBg6zh3UPUyXroLTQ-gh10E_x3J_wHcwKPeg</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>Motofei, I.G.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010701</creationdate><title>A bihormonal model of normal sexual stimulation; the etiology of premature ejaculation</title><author>Motofei, I.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-c35f43982f7ff75657b98f67e01361954471f075b8be90fe6bca7b1f41cd50193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Ejaculation</topic><topic>Estrogens - physiology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Models, Biological</topic><topic>Non tumoral diseases</topic><topic>Serotonin - physiology</topic><topic>Testosterone - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Motofei, I.G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical hypotheses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Motofei, I.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A bihormonal model of normal sexual stimulation; the etiology of premature ejaculation</atitle><jtitle>Medical hypotheses</jtitle><addtitle>Med Hypotheses</addtitle><date>2001-07-01</date><risdate>2001</risdate><volume>57</volume><issue>1</issue><spage>93</spage><epage>95</epage><pages>93-95</pages><issn>0306-9877</issn><eissn>1532-2777</eissn><abstract>The physiological sexual excitation is mediated both by the sympathetic and the parasympathetic nervous system. The antagonism between testosterone (Tt) and estrogens (Es) as well as the fact that the dynamics of the sexual excitation in the male are antagonistic to those in the female are nowadays well-known; hence, the hypothesis was emitted that the sympathoparasympathetic sexual excitation is bihormonal mediated, consisting in a very active sexual hormone associated with a weak antagonistic hormone.
Most studies show a serotonergic (ejaculatory) involvement in premature ejaculation (PE). Nevertheless, an effective treatment of PE is rather difficult with selective serotonin reuptake inhibitor drugs and other clinical data even suggest that changes in PE actually involve at first the sexual excitation process and only secondly the ejaculation reflex.
Thus, a therapeutic model for PE is set up, starting from the physiological aspects described and from the presumed pathophysiological mechanism in PE.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>11421633</pmid><doi>10.1054/mehy.2001.1296</doi><tpages>3</tpages></addata></record> |
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subjects | Biological and medical sciences Ejaculation Estrogens - physiology Gynecology. Andrology. Obstetrics Humans Male Male genital diseases Medical sciences Models, Biological Non tumoral diseases Serotonin - physiology Testosterone - physiology |
title | A bihormonal model of normal sexual stimulation; the etiology of premature ejaculation |
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