Immunostimulatory effects of polar glycopeptidolipids of Mycobacterium chelonae for inactivated rabies vaccine
Humoral and cellular immune responses were analyzed with Fuenzalida–Palacios rabies vaccine associated with pGPL-Mc, polar glycopeptidolipids extracted from Mycobacterium chelonae, aiming at its use as adjuvant. These results were compared to those obtained with BCG, a well-known immunostimulator, u...
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| Veröffentlicht in: | Vaccine 2000-04, Vol.18 (20), p.2125-2131 |
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| creator | de Souza Matos, Denise Cristina Marcovistz, Rugimar Neway, Tsehay da Silva, Andrea Marques Vieira Alves, Eloisa Nunes Pilet, Charles |
| description | Humoral and cellular immune responses were analyzed with Fuenzalida–Palacios rabies vaccine associated with pGPL-Mc, polar glycopeptidolipids extracted from
Mycobacterium chelonae, aiming at its use as adjuvant. These results were compared to those obtained with BCG, a well-known immunostimulator, under the same conditions. Rabies vaccine plus pGPL-Mc (2.5 mg/kg) induced a significant increase in serum neutralizing activity, in vitro lymphocyte proliferation (spontaneous, specific and mitogen stimulation) and delayed type hypersensibility. In addition, pGPL-Mc, as well as BCG, enhanced the vaccine potency. Our results support further studies to encourage the use of pGPL-Mc as an immunostimulator of veterinary vaccines, before consideration for human vaccines. |
| doi_str_mv | 10.1016/S0264-410X(99)00544-7 |
| format | Article |
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Mycobacterium chelonae, aiming at its use as adjuvant. These results were compared to those obtained with BCG, a well-known immunostimulator, under the same conditions. Rabies vaccine plus pGPL-Mc (2.5 mg/kg) induced a significant increase in serum neutralizing activity, in vitro lymphocyte proliferation (spontaneous, specific and mitogen stimulation) and delayed type hypersensibility. In addition, pGPL-Mc, as well as BCG, enhanced the vaccine potency. Our results support further studies to encourage the use of pGPL-Mc as an immunostimulator of veterinary vaccines, before consideration for human vaccines.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/S0264-410X(99)00544-7</identifier><identifier>PMID: 10715527</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adjuvants ; Adjuvants, Immunologic - adverse effects ; Animals ; Antibodies, Viral - biosynthesis ; Antibodies, Viral - immunology ; Antigens, Bacterial - adverse effects ; Antigens, Bacterial - immunology ; BCG Vaccine - immunology ; Biological and medical sciences ; Chemical Phenomena ; Chemistry, Physical ; Female ; Fundamental and applied biological sciences. Psychology ; Glycopeptides - adverse effects ; Glycopeptides - immunology ; glycopeptidolipids ; Humans ; Hypersensitivity, Delayed - etiology ; Immune responses ; Immunity, Cellular ; Interferons - biosynthesis ; Lymphocyte Activation - immunology ; Mice ; Mice, Inbred BALB C ; Microbiology ; Mycobacterium chelonae ; Mycobacterium chelonae - immunology ; Neutralization Tests ; Rabies vaccine ; Rabies Vaccines - adverse effects ; Rabies Vaccines - immunology ; rabies virus ; Rabies virus - immunology ; Safety ; Spleen - immunology ; Thymus Gland - immunology ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Virology</subject><ispartof>Vaccine, 2000-04, Vol.18 (20), p.2125-2131</ispartof><rights>2000 Elsevier Science Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-462b5d9a663da9ad4801db76649701396da5d681525172a9b0f98cc68dbde53b3</citedby><cites>FETCH-LOGICAL-c421t-462b5d9a663da9ad4801db76649701396da5d681525172a9b0f98cc68dbde53b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0264-410X(99)00544-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1404053$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10715527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Souza Matos, Denise Cristina</creatorcontrib><creatorcontrib>Marcovistz, Rugimar</creatorcontrib><creatorcontrib>Neway, Tsehay</creatorcontrib><creatorcontrib>da Silva, Andrea Marques Vieira</creatorcontrib><creatorcontrib>Alves, Eloisa Nunes</creatorcontrib><creatorcontrib>Pilet, Charles</creatorcontrib><title>Immunostimulatory effects of polar glycopeptidolipids of Mycobacterium chelonae for inactivated rabies vaccine</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Humoral and cellular immune responses were analyzed with Fuenzalida–Palacios rabies vaccine associated with pGPL-Mc, polar glycopeptidolipids extracted from
Mycobacterium chelonae, aiming at its use as adjuvant. These results were compared to those obtained with BCG, a well-known immunostimulator, under the same conditions. Rabies vaccine plus pGPL-Mc (2.5 mg/kg) induced a significant increase in serum neutralizing activity, in vitro lymphocyte proliferation (spontaneous, specific and mitogen stimulation) and delayed type hypersensibility. In addition, pGPL-Mc, as well as BCG, enhanced the vaccine potency. Our results support further studies to encourage the use of pGPL-Mc as an immunostimulator of veterinary vaccines, before consideration for human vaccines.</description><subject>Adjuvants</subject><subject>Adjuvants, Immunologic - adverse effects</subject><subject>Animals</subject><subject>Antibodies, Viral - biosynthesis</subject><subject>Antibodies, Viral - immunology</subject><subject>Antigens, Bacterial - adverse effects</subject><subject>Antigens, Bacterial - immunology</subject><subject>BCG Vaccine - immunology</subject><subject>Biological and medical sciences</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycopeptides - adverse effects</subject><subject>Glycopeptides - immunology</subject><subject>glycopeptidolipids</subject><subject>Humans</subject><subject>Hypersensitivity, Delayed - etiology</subject><subject>Immune responses</subject><subject>Immunity, Cellular</subject><subject>Interferons - biosynthesis</subject><subject>Lymphocyte Activation - immunology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Mycobacterium chelonae</subject><subject>Mycobacterium chelonae - immunology</subject><subject>Neutralization Tests</subject><subject>Rabies vaccine</subject><subject>Rabies Vaccines - adverse effects</subject><subject>Rabies Vaccines - immunology</subject><subject>rabies virus</subject><subject>Rabies virus - immunology</subject><subject>Safety</subject><subject>Spleen - immunology</subject><subject>Thymus Gland - immunology</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Virology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQQC0EotuWnwDyASE4BOzEn6cKVZRWKuJAkbhZjj0BIycOdrLS_nvc3RXl1tNIM29m7HkIvaTkPSVUfPhGWsEaRsmPt1q_I4Qz1sgnaEOV7JqWU_UUbf4hJ-i0lN-kUh3Vz9EJJZJy3soNmm7GcZ1SWcK4RrukvMMwDOCWgtOA5xRtxj_jzqUZ5iX4FMMc_L72pSZ76xbIYR2x-wUxTRbwkDIOU82HrV3A42z7AAVvrXNhgnP0bLCxwItjPEPfrz7dXV43t18_31x-vG0ca-nSMNH23GsrROettp4pQn0vhWBaEtpp4S33QlFePypbq3syaOWcUL73wLu-O0NvDnPnnP6sUBYzhuIgRjtBWouRRAumlHoUpJJTwbWuID-ALqdSMgxmzmG0eWcoMfdGzN6IuT-30drsjRhZ-14dF6z9CP6_roOCCrw-ArY4G4dsJxfKA8cIq9oqdnHAoJ5tGyCb4gJMDnzIVZfxKTzykr_7uaok</recordid><startdate>20000414</startdate><enddate>20000414</enddate><creator>de Souza Matos, Denise Cristina</creator><creator>Marcovistz, Rugimar</creator><creator>Neway, Tsehay</creator><creator>da Silva, Andrea Marques Vieira</creator><creator>Alves, Eloisa Nunes</creator><creator>Pilet, Charles</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20000414</creationdate><title>Immunostimulatory effects of polar glycopeptidolipids of Mycobacterium chelonae for inactivated rabies vaccine</title><author>de Souza Matos, Denise Cristina ; Marcovistz, Rugimar ; Neway, Tsehay ; da Silva, Andrea Marques Vieira ; Alves, Eloisa Nunes ; Pilet, Charles</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-462b5d9a663da9ad4801db76649701396da5d681525172a9b0f98cc68dbde53b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adjuvants</topic><topic>Adjuvants, Immunologic - adverse effects</topic><topic>Animals</topic><topic>Antibodies, Viral - biosynthesis</topic><topic>Antibodies, Viral - immunology</topic><topic>Antigens, Bacterial - adverse effects</topic><topic>Antigens, Bacterial - immunology</topic><topic>BCG Vaccine - immunology</topic><topic>Biological and medical sciences</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycopeptides - adverse effects</topic><topic>Glycopeptides - immunology</topic><topic>glycopeptidolipids</topic><topic>Humans</topic><topic>Hypersensitivity, Delayed - etiology</topic><topic>Immune responses</topic><topic>Immunity, Cellular</topic><topic>Interferons - biosynthesis</topic><topic>Lymphocyte Activation - immunology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Mycobacterium chelonae</topic><topic>Mycobacterium chelonae - immunology</topic><topic>Neutralization Tests</topic><topic>Rabies vaccine</topic><topic>Rabies Vaccines - adverse effects</topic><topic>Rabies Vaccines - immunology</topic><topic>rabies virus</topic><topic>Rabies virus - immunology</topic><topic>Safety</topic><topic>Spleen - immunology</topic><topic>Thymus Gland - immunology</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Souza Matos, Denise Cristina</creatorcontrib><creatorcontrib>Marcovistz, Rugimar</creatorcontrib><creatorcontrib>Neway, Tsehay</creatorcontrib><creatorcontrib>da Silva, Andrea Marques Vieira</creatorcontrib><creatorcontrib>Alves, Eloisa Nunes</creatorcontrib><creatorcontrib>Pilet, Charles</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Souza Matos, Denise Cristina</au><au>Marcovistz, Rugimar</au><au>Neway, Tsehay</au><au>da Silva, Andrea Marques Vieira</au><au>Alves, Eloisa Nunes</au><au>Pilet, Charles</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunostimulatory effects of polar glycopeptidolipids of Mycobacterium chelonae for inactivated rabies vaccine</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2000-04-14</date><risdate>2000</risdate><volume>18</volume><issue>20</issue><spage>2125</spage><epage>2131</epage><pages>2125-2131</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Humoral and cellular immune responses were analyzed with Fuenzalida–Palacios rabies vaccine associated with pGPL-Mc, polar glycopeptidolipids extracted from
Mycobacterium chelonae, aiming at its use as adjuvant. These results were compared to those obtained with BCG, a well-known immunostimulator, under the same conditions. Rabies vaccine plus pGPL-Mc (2.5 mg/kg) induced a significant increase in serum neutralizing activity, in vitro lymphocyte proliferation (spontaneous, specific and mitogen stimulation) and delayed type hypersensibility. In addition, pGPL-Mc, as well as BCG, enhanced the vaccine potency. Our results support further studies to encourage the use of pGPL-Mc as an immunostimulator of veterinary vaccines, before consideration for human vaccines.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>10715527</pmid><doi>10.1016/S0264-410X(99)00544-7</doi><tpages>7</tpages></addata></record> |
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| subjects | Adjuvants Adjuvants, Immunologic - adverse effects Animals Antibodies, Viral - biosynthesis Antibodies, Viral - immunology Antigens, Bacterial - adverse effects Antigens, Bacterial - immunology BCG Vaccine - immunology Biological and medical sciences Chemical Phenomena Chemistry, Physical Female Fundamental and applied biological sciences. Psychology Glycopeptides - adverse effects Glycopeptides - immunology glycopeptidolipids Humans Hypersensitivity, Delayed - etiology Immune responses Immunity, Cellular Interferons - biosynthesis Lymphocyte Activation - immunology Mice Mice, Inbred BALB C Microbiology Mycobacterium chelonae Mycobacterium chelonae - immunology Neutralization Tests Rabies vaccine Rabies Vaccines - adverse effects Rabies Vaccines - immunology rabies virus Rabies virus - immunology Safety Spleen - immunology Thymus Gland - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Virology |
| title | Immunostimulatory effects of polar glycopeptidolipids of Mycobacterium chelonae for inactivated rabies vaccine |
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