Time of day determines modulation of synaptic transmission by adenosine in the rat hippocampal slices
Adenosine, an endogenous modulator of synaptic transmission, has been implicated in regulation of sleep and arousal. The effect of adenosine on neuronal excitability depends on its concentration in the extracellular space. The present study shows that the state of activity of laboratory rats determi...
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| Veröffentlicht in: | Neuroscience letters 2000-03, Vol.282 (3), p.200-202 |
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| container_title | Neuroscience letters |
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| creator | Liu, D.K-C Horner, R.L Wojtowicz, J.M |
| description | Adenosine, an endogenous modulator of synaptic transmission, has been implicated in regulation of sleep and arousal. The effect of adenosine on neuronal excitability depends on its concentration in the extracellular space. The present study shows that the state of activity of laboratory rats determines the level of tonic inhibition by adenosine in hippocampal slices prepared from these animals. Thus, slices taken at the end of the active period showed significantly more inhibition by adenosine, as determined by the effects of the A1 receptor blocker 8-CPT, in comparison to slices taken in the inactive state. The results support the proposed role of adenosine in regulation of sleep and arousal and point to the importance of the time of day at which slices for electrophysiological experiments are prepared. |
| doi_str_mv | 10.1016/S0304-3940(00)00881-8 |
| format | Article |
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The results support the proposed role of adenosine in regulation of sleep and arousal and point to the importance of the time of day at which slices for electrophysiological experiments are prepared.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(00)00881-8</identifier><identifier>PMID: 10717426</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adenosine ; Adenosine - physiology ; Animals ; Biological and medical sciences ; Central nervous system ; Circadian Rhythm ; Electrophysiology ; Excitatory Postsynaptic Potentials ; Fundamental and applied biological sciences. 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The effect of adenosine on neuronal excitability depends on its concentration in the extracellular space. The present study shows that the state of activity of laboratory rats determines the level of tonic inhibition by adenosine in hippocampal slices prepared from these animals. Thus, slices taken at the end of the active period showed significantly more inhibition by adenosine, as determined by the effects of the A1 receptor blocker 8-CPT, in comparison to slices taken in the inactive state. The results support the proposed role of adenosine in regulation of sleep and arousal and point to the importance of the time of day at which slices for electrophysiological experiments are prepared.</description><subject>Adenosine</subject><subject>Adenosine - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Circadian Rhythm</subject><subject>Electrophysiology</subject><subject>Excitatory Postsynaptic Potentials</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampal slices</subject><subject>Hippocampus</subject><subject>Hippocampus - physiology</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sleep</subject><subject>Synaptic Transmission - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7rj6E5QcRPTQWkk6SfdpkcUvWPDgeg41STUb6S-TjDD_3rQzqLeFgqKopz54X8aeC3grQJh330BB26i-hdcAbwC6TjTdA7YTnZWN7a18yHZ_kQv2JOcfAKCFbh-zCwFW2FaaHaPbOBFfBh7wyAMVSlOcKfNpCYcRS1zmrZmPM64lel4SznmKOW-N_ZFjoHnJdYLHmZc74gkLv4vrunicVhx5HqOn_JQ9GnDM9OycL9n3jx9urz83N18_fbl-f9P4VorSeDRGCNn5QfTGEqqu7aUJ0A2WyAqtAb0eUJtgSaPWSlqFtejlvtdSDOqSvTrtXdPy80C5uPqrp3HEmZZDdhZ6o7To7gWFNW2rtKmgPoE-LTknGtya4oTp6AS4zQj3xwi3qexgi2qE2w68OB847CcK_02dlK_AyzOA2eM4VGF9zP84JQ0IXbGrE0ZVtl-Rkss-0uwpxES-uLDEez75DTYvpNY</recordid><startdate>20000324</startdate><enddate>20000324</enddate><creator>Liu, D.K-C</creator><creator>Horner, R.L</creator><creator>Wojtowicz, J.M</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20000324</creationdate><title>Time of day determines modulation of synaptic transmission by adenosine in the rat hippocampal slices</title><author>Liu, D.K-C ; Horner, R.L ; Wojtowicz, J.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-ca661128cf1967ea384926d08f7ee71550ac5fa56d7e5a553273a6d792b9521f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adenosine</topic><topic>Adenosine - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Circadian Rhythm</topic><topic>Electrophysiology</topic><topic>Excitatory Postsynaptic Potentials</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampal slices</topic><topic>Hippocampus</topic><topic>Hippocampus - physiology</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sleep</topic><topic>Synaptic Transmission - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, D.K-C</creatorcontrib><creatorcontrib>Horner, R.L</creatorcontrib><creatorcontrib>Wojtowicz, J.M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, D.K-C</au><au>Horner, R.L</au><au>Wojtowicz, J.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Time of day determines modulation of synaptic transmission by adenosine in the rat hippocampal slices</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2000-03-24</date><risdate>2000</risdate><volume>282</volume><issue>3</issue><spage>200</spage><epage>202</epage><pages>200-202</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Adenosine, an endogenous modulator of synaptic transmission, has been implicated in regulation of sleep and arousal. The effect of adenosine on neuronal excitability depends on its concentration in the extracellular space. The present study shows that the state of activity of laboratory rats determines the level of tonic inhibition by adenosine in hippocampal slices prepared from these animals. Thus, slices taken at the end of the active period showed significantly more inhibition by adenosine, as determined by the effects of the A1 receptor blocker 8-CPT, in comparison to slices taken in the inactive state. The results support the proposed role of adenosine in regulation of sleep and arousal and point to the importance of the time of day at which slices for electrophysiological experiments are prepared.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10717426</pmid><doi>10.1016/S0304-3940(00)00881-8</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 2000-03, Vol.282 (3), p.200-202 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adenosine Adenosine - physiology Animals Biological and medical sciences Central nervous system Circadian Rhythm Electrophysiology Excitatory Postsynaptic Potentials Fundamental and applied biological sciences. Psychology Hippocampal slices Hippocampus Hippocampus - physiology In Vitro Techniques Male Rats Rats, Wistar Sleep Synaptic Transmission - physiology Vertebrates: nervous system and sense organs |
| title | Time of day determines modulation of synaptic transmission by adenosine in the rat hippocampal slices |
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