ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses
We examined the requirement for and cooperation between CD28 and inducible costimulator (ICOS) in effective T helper (TH) cell responses in vivo. We found that both CD28 and ICOS were critical in determining the outcome of an immune response; cytolytic T lymphocyte-associated antigen 4-immunoglobuli...
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| Veröffentlicht in: | Nature immunology 2001-07, Vol.2 (7), p.597-604 |
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| creator | Coyle, Anthony J Gonzalo, Jose Angel Tian, Jane Delaney, Tracy Corcoran, Justin Rottman, James B Lora, Jose Al-garawi, Amal Kroczek, Richard Gutierrez-Ramos, Jose Carlos |
| description | We examined the requirement for and cooperation between CD28 and inducible costimulator (ICOS) in effective T helper (TH) cell responses in vivo. We found that both CD28 and ICOS were critical in determining the outcome of an immune response; cytolytic T lymphocyte-associated antigen 4-immunoglobulin (CTLA-4-Ig), ICOS-Ig and/or a neutralizing ICOS monoclonal antibody attenuated T cell expansion, TH2 cytokine production and eosinophilic inflammation. CD28-dependent signaling was essential during priming, whereas ICOS-B7RP-1 regulated TH effector responses, and the up-regulation of chemokine receptors that determine T cell migration. Our data suggests a scenario whereby both molecules regulate the outcome of the immune response but play separate key roles: CD28 primes T cells and ICOS regulates effector responses. |
| doi_str_mv | 10.1038/89739 |
| format | Article |
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We found that both CD28 and ICOS were critical in determining the outcome of an immune response; cytolytic T lymphocyte-associated antigen 4-immunoglobulin (CTLA-4-Ig), ICOS-Ig and/or a neutralizing ICOS monoclonal antibody attenuated T cell expansion, TH2 cytokine production and eosinophilic inflammation. CD28-dependent signaling was essential during priming, whereas ICOS-B7RP-1 regulated TH effector responses, and the up-regulation of chemokine receptors that determine T cell migration. Our data suggests a scenario whereby both molecules regulate the outcome of the immune response but play separate key roles: CD28 primes T cells and ICOS regulates effector responses.</description><identifier>ISSN: 1529-2908</identifier><identifier>EISSN: 1529-2916</identifier><identifier>DOI: 10.1038/89739</identifier><identifier>PMID: 11429543</identifier><language>eng</language><publisher>United States: Nature Publishing Group</publisher><subject>Abatacept ; Animals ; Antibodies, Monoclonal - biosynthesis ; Antigens, CD ; Antigens, Differentiation - genetics ; Antigens, Differentiation, T-Lymphocyte - genetics ; Antigens, Differentiation, T-Lymphocyte - immunology ; CD28 Antigens - genetics ; CTLA-4 Antigen ; CTLA-4 protein ; Cytokines - biosynthesis ; Gene Expression ; ICOS protein ; Immune response ; Immunity, Mucosal - immunology ; Immunoconjugates ; Immunoglobulin E - biosynthesis ; Inducible T-Cell Co-Stimulator Protein ; Lung - immunology ; Lymphocytes ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Neutralization Tests ; Rats ; Rats, Inbred WKY ; Receptors, CCR3 ; Receptors, CCR4 ; Receptors, CCR8 ; Receptors, Chemokine - genetics ; Respiratory Mucosa - immunology ; Th1 Cells - immunology ; Th2 Cells - immunology</subject><ispartof>Nature immunology, 2001-07, Vol.2 (7), p.597-604</ispartof><rights>COPYRIGHT 2001 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jul 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-c6a97dbc02ad6ca4e65afb7125c867ea787e3fe582f1031d1cf6568bf9520c303</citedby><cites>FETCH-LOGICAL-c429t-c6a97dbc02ad6ca4e65afb7125c867ea787e3fe582f1031d1cf6568bf9520c303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,2728,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11429543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coyle, Anthony J</creatorcontrib><creatorcontrib>Gonzalo, Jose Angel</creatorcontrib><creatorcontrib>Tian, Jane</creatorcontrib><creatorcontrib>Delaney, Tracy</creatorcontrib><creatorcontrib>Corcoran, Justin</creatorcontrib><creatorcontrib>Rottman, James B</creatorcontrib><creatorcontrib>Lora, Jose</creatorcontrib><creatorcontrib>Al-garawi, Amal</creatorcontrib><creatorcontrib>Kroczek, Richard</creatorcontrib><creatorcontrib>Gutierrez-Ramos, Jose Carlos</creatorcontrib><title>ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses</title><title>Nature immunology</title><addtitle>Nat Immunol</addtitle><description>We examined the requirement for and cooperation between CD28 and inducible costimulator (ICOS) in effective T helper (TH) cell responses in vivo. We found that both CD28 and ICOS were critical in determining the outcome of an immune response; cytolytic T lymphocyte-associated antigen 4-immunoglobulin (CTLA-4-Ig), ICOS-Ig and/or a neutralizing ICOS monoclonal antibody attenuated T cell expansion, TH2 cytokine production and eosinophilic inflammation. CD28-dependent signaling was essential during priming, whereas ICOS-B7RP-1 regulated TH effector responses, and the up-regulation of chemokine receptors that determine T cell migration. Our data suggests a scenario whereby both molecules regulate the outcome of the immune response but play separate key roles: CD28 primes T cells and ICOS regulates effector responses.</description><subject>Abatacept</subject><subject>Animals</subject><subject>Antibodies, Monoclonal - biosynthesis</subject><subject>Antigens, CD</subject><subject>Antigens, Differentiation - genetics</subject><subject>Antigens, Differentiation, T-Lymphocyte - genetics</subject><subject>Antigens, Differentiation, T-Lymphocyte - immunology</subject><subject>CD28 Antigens - genetics</subject><subject>CTLA-4 Antigen</subject><subject>CTLA-4 protein</subject><subject>Cytokines - biosynthesis</subject><subject>Gene Expression</subject><subject>ICOS protein</subject><subject>Immune response</subject><subject>Immunity, Mucosal - immunology</subject><subject>Immunoconjugates</subject><subject>Immunoglobulin E - biosynthesis</subject><subject>Inducible T-Cell Co-Stimulator Protein</subject><subject>Lung - immunology</subject><subject>Lymphocytes</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Neutralization Tests</subject><subject>Rats</subject><subject>Rats, Inbred WKY</subject><subject>Receptors, CCR3</subject><subject>Receptors, CCR4</subject><subject>Receptors, CCR8</subject><subject>Receptors, Chemokine - 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Academic</collection><jtitle>Nature immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coyle, Anthony J</au><au>Gonzalo, Jose Angel</au><au>Tian, Jane</au><au>Delaney, Tracy</au><au>Corcoran, Justin</au><au>Rottman, James B</au><au>Lora, Jose</au><au>Al-garawi, Amal</au><au>Kroczek, Richard</au><au>Gutierrez-Ramos, Jose Carlos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses</atitle><jtitle>Nature immunology</jtitle><addtitle>Nat Immunol</addtitle><date>2001-07-01</date><risdate>2001</risdate><volume>2</volume><issue>7</issue><spage>597</spage><epage>604</epage><pages>597-604</pages><issn>1529-2908</issn><eissn>1529-2916</eissn><abstract>We examined the requirement for and cooperation between CD28 and inducible costimulator (ICOS) in effective T helper (TH) cell responses in vivo. We found that both CD28 and ICOS were critical in determining the outcome of an immune response; cytolytic T lymphocyte-associated antigen 4-immunoglobulin (CTLA-4-Ig), ICOS-Ig and/or a neutralizing ICOS monoclonal antibody attenuated T cell expansion, TH2 cytokine production and eosinophilic inflammation. CD28-dependent signaling was essential during priming, whereas ICOS-B7RP-1 regulated TH effector responses, and the up-regulation of chemokine receptors that determine T cell migration. Our data suggests a scenario whereby both molecules regulate the outcome of the immune response but play separate key roles: CD28 primes T cells and ICOS regulates effector responses.</abstract><cop>United States</cop><pub>Nature Publishing Group</pub><pmid>11429543</pmid><doi>10.1038/89739</doi><tpages>8</tpages></addata></record> |
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| subjects | Abatacept Animals Antibodies, Monoclonal - biosynthesis Antigens, CD Antigens, Differentiation - genetics Antigens, Differentiation, T-Lymphocyte - genetics Antigens, Differentiation, T-Lymphocyte - immunology CD28 Antigens - genetics CTLA-4 Antigen CTLA-4 protein Cytokines - biosynthesis Gene Expression ICOS protein Immune response Immunity, Mucosal - immunology Immunoconjugates Immunoglobulin E - biosynthesis Inducible T-Cell Co-Stimulator Protein Lung - immunology Lymphocytes Mice Mice, Inbred BALB C Mice, Inbred C57BL Neutralization Tests Rats Rats, Inbred WKY Receptors, CCR3 Receptors, CCR4 Receptors, CCR8 Receptors, Chemokine - genetics Respiratory Mucosa - immunology Th1 Cells - immunology Th2 Cells - immunology |
| title | ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses |
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