Piperazinyl benzamidines: Synthesis and affinity for the delta opioid receptor

Piperazinyl benzamidines were prepared and found to bind to the rat delta (δ) opioid receptor. The most active compounds had a N,N-diethylcarboxamido group and a N-benzyl piperazine. The most potent among these was N,N-diethyl-4-[4-(phenylmethyl)-1-piperazinyl][2-(trifluoromethyl)phenyl]iminomethyl]...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2001-07, Vol.11 (13), p.1741-1743
Hauptverfasser:	Nortey, Samuel O., Baxter, Ellen W., Codd, Ellen E., Zhang, Sui-Po, Reitz, Allen B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzamidines - chemical synthesis Benzamidines - chemistry Benzamidines - metabolism Biological and medical sciences Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Piperazines - chemistry Rats Receptors, Opioid, delta - metabolism
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