ATP-binding Cassette Transporter A1 (ABCA1) Functions as a Cholesterol Efflux Regulatory Protein

ABCA1, an ATP-binding cassette transporter mutated in Tangier disease, promotes cellular phospholipid and cholesterol efflux by loading free apoA-I with these lipids. This process involves binding of apoA-I to the cell surface and phospholipid translocation by ABCA1. The goals of this study were to...

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Veröffentlicht in:	The Journal of biological chemistry 2001-06, Vol.276 (26), p.23742-23747
Hauptverfasser:	Wang, Nan, Silver, David L., Thiele, Christoph, Tall, Alan R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apolipoprotein A-I - metabolism ATP Binding Cassette Transporter 1 ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - physiology Biological Transport - drug effects Cell Line Cholesterol - metabolism Cyclodextrins - pharmacology Glyburide - pharmacology Humans Mutation Phospholipids - metabolism
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