Nitric oxide induces murine thymocyte apoptosis by oxidative injury and a p53-dependent mechanism

Previously, we showed that NO induces thymocyte apoptosis via acaspase‐1‐dependent mechanism [1]. In the present study,we investigated the role of heme oxygenase, catalase, bax, and p53 inthis process. The NO donor, S‐nitroso‐N‐acetyl penicillamine (SNAP),induced DNA fragmentation in thymocytes in a...

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Veröffentlicht in:	Journal of leukocyte biology 2001-07, Vol.70 (1), p.87-95
Hauptverfasser:	Gordon, Sherilyn A., Abou‐Jaoude, Walid, Hoffman, Rosemary A., McCarthy, Susan A., Kim, Young‐Myeong, Zhou, Xin, Zhang, Xiao‐Ru, Simmons, Richard L., Chen, Yue, Schall, Laura, Ford, Henri R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - physiology bax bcl-2-Associated X Protein catalase Catalase - metabolism Coculture Techniques Enzyme Induction - drug effects Erythrocytes - cytology Gene Expression - drug effects glutathione Glutathione - metabolism Heme - metabolism heme oxygenase Heme Oxygenase (Decyclizing) - biosynthesis Heme Oxygenase-1 Iron - metabolism Membrane Proteins Mice Mice, Inbred BALB C Mice, Knockout nitric oxide Nitric Oxide - pharmacology Nitric Oxide Donors - pharmacology Oxidative Stress - drug effects Oxidative Stress - physiology p53 protein Penicillamine - analogs & derivatives Penicillamine - pharmacology Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-bcl-2 - biosynthesis Proto-Oncogene Proteins c-bcl-2 - genetics S-nitroso-N-acetyl penicillamine S-Nitroso-N-Acetylpenicillamine Superoxide Dismutase - metabolism thymus Thymus Gland - cytology Thymus Gland - drug effects Thymus Gland - metabolism Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - physiology
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