Hypoxaemic reperfusion ameliorates the histopathological changes in the pig brain after a severe global cerebral ischaemic insult
We have recently shown that hypoxaemic reperfusion, after an ischaemic brain insult, improves neurological outcome and decreases lipid peroxidation. In the present study, we investigated the effect of hypoxaemic reperfusion on brain histopathological changes. Sixteen pigs subjected to a 10-min globa...
Gespeichert in:
| Veröffentlicht in: | Intensive care medicine 2001-05, Vol.27 (5), p.905-910 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 910 |
|---|---|
| container_issue | 5 |
| container_start_page | 905 |
| container_title | Intensive care medicine |
| container_volume | 27 |
| creator | DOUZINAS, Emmanuel E PATSOURIS, Efstratios ROUSSOS, Charis KYPRIADES, Epaminondas M MAKRIS, Dimitrios J ANDRIANAKIS, Ilias KORKOLOPOULOU, Penelope BOURSINOS, Vasilios PAPALOIS, Apostolos SOTIROPOULOU, Christina DAVARIS, Panagiotis |
| description | We have recently shown that hypoxaemic reperfusion, after an ischaemic brain insult, improves neurological outcome and decreases lipid peroxidation. In the present study, we investigated the effect of hypoxaemic reperfusion on brain histopathological changes.
Sixteen pigs subjected to a 10-min global cerebral ischaemia were either hypoxaemically (PaO2 = 35 mmHg, hypoxaemic reperfusion (HR) group, n = 8) or hyperoxaemically (PaO2 > 300 mmHg, control (C) group, n = 8) reperfused. The brains were removed 24 h after reperfusion and six neuropathological abnormalities were evaluated blindly and scored semi-quantitatively (0: normal to 3: severe injury) on eight representative regions of the brain. The overall cumulative score of the abnormalities and their regional prevalence, as well as the neurological outcome, were compared between the two groups.
The neuronal degeneration, assessed in terms of cumulative score (P = 0.002) and regional prevalence (P = 0.025 to P = 0.041), was lower in the HR group than in the C group. Spongy degeneration attained statistically significant difference only in cerebellum (P = 0.002) and inflammation only in hippocampus (P = 0.046) but the difference in the cumulative score of these abnormalities was not statistically significant. The difference of the three neurological assessments over time was statistically significant between the two groups, i.e. after resuscitation (P = 0.001), at 8 h (P = 0.006) and at 24 h (P = 0.001) after reperfusion.
Hypoxaemic reperfusion during resuscitation from a severe global ischaemic cerebral insult is associated with statistically significantly fewer histopathological changes of the brain than in controls. This is associated with a superior neurological outcome. |
| doi_str_mv | 10.1007/s001340100932 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70959074</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2631879581</sourcerecordid><originalsourceid>FETCH-LOGICAL-c416t-f69271c0cc053b113cf3fb637fff3c8d59e79ecccfe6555e01dcd1f84e8fc9f3</originalsourceid><addsrcrecordid>eNp90U1v1DAQBmALgeiycOSKLCohLgFPbCfxEVWFVqrEpffI8Y53XTlxsBPUHvnnTNsVCA492dY8Hn-8jL0F8QmEaD8XIUAqQXMj62dsA0rWFdSye842Qqq6Uo2qT9irUm5Ito2Gl-wESAmtug37dXE3p1uLY3A844zZryWkidsRY0jZLlj4ckB-CGVJs10OKaZ9cDZyd7DTnqphegBz2PMhW1pZv2Dmlhf8iRn5PqbhntOc6pGHQjsfzgtTWePymr3wNhZ8cxy37Prr-fXZRXX1_dvl2Zeryilolso3pm7BCeeElgOAdF76oZGt9166bqcNtgadcx4brTUK2Lkd-E5h553xcss-PLadc_qxYln6kW6CMdoJ01r6VhhtRKsIfnwSggAFwrR0jS17_x-9SWue6BW9MVLTX1MQW1Y9IpdTKRl9P-cw2nxHnfr7CPt_IiT_7th0HUbc_dXHzAicHoEtFITPdnKh_HHGQKOl_A3uZqUl</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>993565112</pqid></control><display><type>article</type><title>Hypoxaemic reperfusion ameliorates the histopathological changes in the pig brain after a severe global cerebral ischaemic insult</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>DOUZINAS, Emmanuel E ; PATSOURIS, Efstratios ; ROUSSOS, Charis ; KYPRIADES, Epaminondas M ; MAKRIS, Dimitrios J ; ANDRIANAKIS, Ilias ; KORKOLOPOULOU, Penelope ; BOURSINOS, Vasilios ; PAPALOIS, Apostolos ; SOTIROPOULOU, Christina ; DAVARIS, Panagiotis</creator><creatorcontrib>DOUZINAS, Emmanuel E ; PATSOURIS, Efstratios ; ROUSSOS, Charis ; KYPRIADES, Epaminondas M ; MAKRIS, Dimitrios J ; ANDRIANAKIS, Ilias ; KORKOLOPOULOU, Penelope ; BOURSINOS, Vasilios ; PAPALOIS, Apostolos ; SOTIROPOULOU, Christina ; DAVARIS, Panagiotis</creatorcontrib><description>We have recently shown that hypoxaemic reperfusion, after an ischaemic brain insult, improves neurological outcome and decreases lipid peroxidation. In the present study, we investigated the effect of hypoxaemic reperfusion on brain histopathological changes.
Sixteen pigs subjected to a 10-min global cerebral ischaemia were either hypoxaemically (PaO2 = 35 mmHg, hypoxaemic reperfusion (HR) group, n = 8) or hyperoxaemically (PaO2 > 300 mmHg, control (C) group, n = 8) reperfused. The brains were removed 24 h after reperfusion and six neuropathological abnormalities were evaluated blindly and scored semi-quantitatively (0: normal to 3: severe injury) on eight representative regions of the brain. The overall cumulative score of the abnormalities and their regional prevalence, as well as the neurological outcome, were compared between the two groups.
The neuronal degeneration, assessed in terms of cumulative score (P = 0.002) and regional prevalence (P = 0.025 to P = 0.041), was lower in the HR group than in the C group. Spongy degeneration attained statistically significant difference only in cerebellum (P = 0.002) and inflammation only in hippocampus (P = 0.046) but the difference in the cumulative score of these abnormalities was not statistically significant. The difference of the three neurological assessments over time was statistically significant between the two groups, i.e. after resuscitation (P = 0.001), at 8 h (P = 0.006) and at 24 h (P = 0.001) after reperfusion.
Hypoxaemic reperfusion during resuscitation from a severe global ischaemic cerebral insult is associated with statistically significantly fewer histopathological changes of the brain than in controls. This is associated with a superior neurological outcome.</description><identifier>ISSN: 0342-4642</identifier><identifier>EISSN: 1432-1238</identifier><identifier>DOI: 10.1007/s001340100932</identifier><identifier>PMID: 11430548</identifier><identifier>CODEN: ICMED9</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Brain ; Brain injury ; Brain Ischemia - pathology ; Brain Ischemia - therapy ; Cardiac arrest ; Cardiopulmonary Resuscitation - methods ; Carotid arteries ; Catheters ; Cerebellum ; Disease Models, Animal ; Emergency and intensive care: comas and nervous system diseases ; Hippocampus ; Hogs ; Hypoxia, Brain - prevention & control ; Inflammation ; Intensive care medicine ; Ischemia ; Laboratories ; Lipid peroxidation ; Lipids ; Male ; Medical sciences ; Neurodegeneration ; Ostomy ; Pharmaceutical industry ; Random Allocation ; Reperfusion ; Reperfusion - methods ; Statistical analysis ; Swine ; Veins & arteries</subject><ispartof>Intensive care medicine, 2001-05, Vol.27 (5), p.905-910</ispartof><rights>2001 INIST-CNRS</rights><rights>Springer-Verlag 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-f69271c0cc053b113cf3fb637fff3c8d59e79ecccfe6555e01dcd1f84e8fc9f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=991653$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11430548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DOUZINAS, Emmanuel E</creatorcontrib><creatorcontrib>PATSOURIS, Efstratios</creatorcontrib><creatorcontrib>ROUSSOS, Charis</creatorcontrib><creatorcontrib>KYPRIADES, Epaminondas M</creatorcontrib><creatorcontrib>MAKRIS, Dimitrios J</creatorcontrib><creatorcontrib>ANDRIANAKIS, Ilias</creatorcontrib><creatorcontrib>KORKOLOPOULOU, Penelope</creatorcontrib><creatorcontrib>BOURSINOS, Vasilios</creatorcontrib><creatorcontrib>PAPALOIS, Apostolos</creatorcontrib><creatorcontrib>SOTIROPOULOU, Christina</creatorcontrib><creatorcontrib>DAVARIS, Panagiotis</creatorcontrib><title>Hypoxaemic reperfusion ameliorates the histopathological changes in the pig brain after a severe global cerebral ischaemic insult</title><title>Intensive care medicine</title><addtitle>Intensive Care Med</addtitle><description>We have recently shown that hypoxaemic reperfusion, after an ischaemic brain insult, improves neurological outcome and decreases lipid peroxidation. In the present study, we investigated the effect of hypoxaemic reperfusion on brain histopathological changes.
Sixteen pigs subjected to a 10-min global cerebral ischaemia were either hypoxaemically (PaO2 = 35 mmHg, hypoxaemic reperfusion (HR) group, n = 8) or hyperoxaemically (PaO2 > 300 mmHg, control (C) group, n = 8) reperfused. The brains were removed 24 h after reperfusion and six neuropathological abnormalities were evaluated blindly and scored semi-quantitatively (0: normal to 3: severe injury) on eight representative regions of the brain. The overall cumulative score of the abnormalities and their regional prevalence, as well as the neurological outcome, were compared between the two groups.
The neuronal degeneration, assessed in terms of cumulative score (P = 0.002) and regional prevalence (P = 0.025 to P = 0.041), was lower in the HR group than in the C group. Spongy degeneration attained statistically significant difference only in cerebellum (P = 0.002) and inflammation only in hippocampus (P = 0.046) but the difference in the cumulative score of these abnormalities was not statistically significant. The difference of the three neurological assessments over time was statistically significant between the two groups, i.e. after resuscitation (P = 0.001), at 8 h (P = 0.006) and at 24 h (P = 0.001) after reperfusion.
Hypoxaemic reperfusion during resuscitation from a severe global ischaemic cerebral insult is associated with statistically significantly fewer histopathological changes of the brain than in controls. This is associated with a superior neurological outcome.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain injury</subject><subject>Brain Ischemia - pathology</subject><subject>Brain Ischemia - therapy</subject><subject>Cardiac arrest</subject><subject>Cardiopulmonary Resuscitation - methods</subject><subject>Carotid arteries</subject><subject>Catheters</subject><subject>Cerebellum</subject><subject>Disease Models, Animal</subject><subject>Emergency and intensive care: comas and nervous system diseases</subject><subject>Hippocampus</subject><subject>Hogs</subject><subject>Hypoxia, Brain - prevention & control</subject><subject>Inflammation</subject><subject>Intensive care medicine</subject><subject>Ischemia</subject><subject>Laboratories</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurodegeneration</subject><subject>Ostomy</subject><subject>Pharmaceutical industry</subject><subject>Random Allocation</subject><subject>Reperfusion</subject><subject>Reperfusion - methods</subject><subject>Statistical analysis</subject><subject>Swine</subject><subject>Veins & arteries</subject><issn>0342-4642</issn><issn>1432-1238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp90U1v1DAQBmALgeiycOSKLCohLgFPbCfxEVWFVqrEpffI8Y53XTlxsBPUHvnnTNsVCA492dY8Hn-8jL0F8QmEaD8XIUAqQXMj62dsA0rWFdSye842Qqq6Uo2qT9irUm5Ito2Gl-wESAmtug37dXE3p1uLY3A844zZryWkidsRY0jZLlj4ckB-CGVJs10OKaZ9cDZyd7DTnqphegBz2PMhW1pZv2Dmlhf8iRn5PqbhntOc6pGHQjsfzgtTWePymr3wNhZ8cxy37Prr-fXZRXX1_dvl2Zeryilolso3pm7BCeeElgOAdF76oZGt9166bqcNtgadcx4brTUK2Lkd-E5h553xcss-PLadc_qxYln6kW6CMdoJ01r6VhhtRKsIfnwSggAFwrR0jS17_x-9SWue6BW9MVLTX1MQW1Y9IpdTKRl9P-cw2nxHnfr7CPt_IiT_7th0HUbc_dXHzAicHoEtFITPdnKh_HHGQKOl_A3uZqUl</recordid><startdate>20010501</startdate><enddate>20010501</enddate><creator>DOUZINAS, Emmanuel E</creator><creator>PATSOURIS, Efstratios</creator><creator>ROUSSOS, Charis</creator><creator>KYPRIADES, Epaminondas M</creator><creator>MAKRIS, Dimitrios J</creator><creator>ANDRIANAKIS, Ilias</creator><creator>KORKOLOPOULOU, Penelope</creator><creator>BOURSINOS, Vasilios</creator><creator>PAPALOIS, Apostolos</creator><creator>SOTIROPOULOU, Christina</creator><creator>DAVARIS, Panagiotis</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20010501</creationdate><title>Hypoxaemic reperfusion ameliorates the histopathological changes in the pig brain after a severe global cerebral ischaemic insult</title><author>DOUZINAS, Emmanuel E ; PATSOURIS, Efstratios ; ROUSSOS, Charis ; KYPRIADES, Epaminondas M ; MAKRIS, Dimitrios J ; ANDRIANAKIS, Ilias ; KORKOLOPOULOU, Penelope ; BOURSINOS, Vasilios ; PAPALOIS, Apostolos ; SOTIROPOULOU, Christina ; DAVARIS, Panagiotis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-f69271c0cc053b113cf3fb637fff3c8d59e79ecccfe6555e01dcd1f84e8fc9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain injury</topic><topic>Brain Ischemia - pathology</topic><topic>Brain Ischemia - therapy</topic><topic>Cardiac arrest</topic><topic>Cardiopulmonary Resuscitation - methods</topic><topic>Carotid arteries</topic><topic>Catheters</topic><topic>Cerebellum</topic><topic>Disease Models, Animal</topic><topic>Emergency and intensive care: comas and nervous system diseases</topic><topic>Hippocampus</topic><topic>Hogs</topic><topic>Hypoxia, Brain - prevention & control</topic><topic>Inflammation</topic><topic>Intensive care medicine</topic><topic>Ischemia</topic><topic>Laboratories</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurodegeneration</topic><topic>Ostomy</topic><topic>Pharmaceutical industry</topic><topic>Random Allocation</topic><topic>Reperfusion</topic><topic>Reperfusion - methods</topic><topic>Statistical analysis</topic><topic>Swine</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DOUZINAS, Emmanuel E</creatorcontrib><creatorcontrib>PATSOURIS, Efstratios</creatorcontrib><creatorcontrib>ROUSSOS, Charis</creatorcontrib><creatorcontrib>KYPRIADES, Epaminondas M</creatorcontrib><creatorcontrib>MAKRIS, Dimitrios J</creatorcontrib><creatorcontrib>ANDRIANAKIS, Ilias</creatorcontrib><creatorcontrib>KORKOLOPOULOU, Penelope</creatorcontrib><creatorcontrib>BOURSINOS, Vasilios</creatorcontrib><creatorcontrib>PAPALOIS, Apostolos</creatorcontrib><creatorcontrib>SOTIROPOULOU, Christina</creatorcontrib><creatorcontrib>DAVARIS, Panagiotis</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Intensive care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DOUZINAS, Emmanuel E</au><au>PATSOURIS, Efstratios</au><au>ROUSSOS, Charis</au><au>KYPRIADES, Epaminondas M</au><au>MAKRIS, Dimitrios J</au><au>ANDRIANAKIS, Ilias</au><au>KORKOLOPOULOU, Penelope</au><au>BOURSINOS, Vasilios</au><au>PAPALOIS, Apostolos</au><au>SOTIROPOULOU, Christina</au><au>DAVARIS, Panagiotis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoxaemic reperfusion ameliorates the histopathological changes in the pig brain after a severe global cerebral ischaemic insult</atitle><jtitle>Intensive care medicine</jtitle><addtitle>Intensive Care Med</addtitle><date>2001-05-01</date><risdate>2001</risdate><volume>27</volume><issue>5</issue><spage>905</spage><epage>910</epage><pages>905-910</pages><issn>0342-4642</issn><eissn>1432-1238</eissn><coden>ICMED9</coden><abstract>We have recently shown that hypoxaemic reperfusion, after an ischaemic brain insult, improves neurological outcome and decreases lipid peroxidation. In the present study, we investigated the effect of hypoxaemic reperfusion on brain histopathological changes.
Sixteen pigs subjected to a 10-min global cerebral ischaemia were either hypoxaemically (PaO2 = 35 mmHg, hypoxaemic reperfusion (HR) group, n = 8) or hyperoxaemically (PaO2 > 300 mmHg, control (C) group, n = 8) reperfused. The brains were removed 24 h after reperfusion and six neuropathological abnormalities were evaluated blindly and scored semi-quantitatively (0: normal to 3: severe injury) on eight representative regions of the brain. The overall cumulative score of the abnormalities and their regional prevalence, as well as the neurological outcome, were compared between the two groups.
The neuronal degeneration, assessed in terms of cumulative score (P = 0.002) and regional prevalence (P = 0.025 to P = 0.041), was lower in the HR group than in the C group. Spongy degeneration attained statistically significant difference only in cerebellum (P = 0.002) and inflammation only in hippocampus (P = 0.046) but the difference in the cumulative score of these abnormalities was not statistically significant. The difference of the three neurological assessments over time was statistically significant between the two groups, i.e. after resuscitation (P = 0.001), at 8 h (P = 0.006) and at 24 h (P = 0.001) after reperfusion.
Hypoxaemic reperfusion during resuscitation from a severe global ischaemic cerebral insult is associated with statistically significantly fewer histopathological changes of the brain than in controls. This is associated with a superior neurological outcome.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>11430548</pmid><doi>10.1007/s001340100932</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0342-4642 |
| ispartof | Intensive care medicine, 2001-05, Vol.27 (5), p.905-910 |
| issn | 0342-4642 1432-1238 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70959074 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Brain Brain injury Brain Ischemia - pathology Brain Ischemia - therapy Cardiac arrest Cardiopulmonary Resuscitation - methods Carotid arteries Catheters Cerebellum Disease Models, Animal Emergency and intensive care: comas and nervous system diseases Hippocampus Hogs Hypoxia, Brain - prevention & control Inflammation Intensive care medicine Ischemia Laboratories Lipid peroxidation Lipids Male Medical sciences Neurodegeneration Ostomy Pharmaceutical industry Random Allocation Reperfusion Reperfusion - methods Statistical analysis Swine Veins & arteries |
| title | Hypoxaemic reperfusion ameliorates the histopathological changes in the pig brain after a severe global cerebral ischaemic insult |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T19%3A38%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hypoxaemic%20reperfusion%20ameliorates%20the%20histopathological%20changes%20in%20the%20pig%20brain%20after%20a%20severe%20global%20cerebral%20ischaemic%20insult&rft.jtitle=Intensive%20care%20medicine&rft.au=DOUZINAS,%20Emmanuel%20E&rft.date=2001-05-01&rft.volume=27&rft.issue=5&rft.spage=905&rft.epage=910&rft.pages=905-910&rft.issn=0342-4642&rft.eissn=1432-1238&rft.coden=ICMED9&rft_id=info:doi/10.1007/s001340100932&rft_dat=%3Cproquest_cross%3E2631879581%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=993565112&rft_id=info:pmid/11430548&rfr_iscdi=true |