Feeding dried purple laver (nori) to vitamin B12-deficient rats significantly improves vitamin B12 status
To clarify the bioavailability of vitamin B12 in lyophylized purple laver (nori; Porphyra yezoensis), total vitamin B12 and vitamin B12 analogue contents in the laver were determined, and the effects of feeding the laver to vitamin B12-deficient rats were investigated. The amount of total vitamin B1...
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| Veröffentlicht in: | British journal of nutrition 2001-06, Vol.85 (6), p.699-703 |
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| creator | Takenaka, Shigeo Sugiyama, Sumi Ebara, Shuhei Miyamoto, Emi Abe, Katsuo Tamura, Yoshiyuki Watanabe, Fumio Tsuyama, Shingo Nakano, Yoshihisa |
| description | To clarify the bioavailability of vitamin B12 in lyophylized purple laver (nori; Porphyra yezoensis), total vitamin B12 and vitamin B12 analogue contents in the laver were determined, and the effects of feeding the laver to vitamin B12-deficient rats were investigated. The amount of total vitamin B12 in the dried purple laver was estimated to be 54.5 and 58.6 (SE 5.3 and 7.5 respectively) ΜG/100 g dry weight by lactobacillus bioassay and chemiluminescent assay with hog intrinsic factor respectively. the purple laver contained five types of biologically active vitamin b12 compounds (cyano-, hydroxo-, sulfito-, adenosyl- and methylcobalamin), in which the vitamin b12 coezymes (adenosyl- and methylcobalamin) comprised about 60 % of the total vitamin b12. when 9-week-old vitamin b12-deficient rats, which excreted substantial amounts of methylmalonic acid (71.7(se 20.2) μmol/d) in urine, were fed the diet supplemented with dried purple laver (10 μg/kg diet) for 20 d, urinary methylmalonic acid excretion (as an index of vitamin B12 deficiency) became undetectable and hepatic vitamin B12 (especially adenosylcobalamin) levels were significantly increased. These results indicate that vitamin B12 in dried purple laver is bioavailable to rats. |
| doi_str_mv | 10.1079/BJN2001352 |
| format | Article |
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The amount of total vitamin B12 in the dried purple laver was estimated to be 54.5 and 58.6 (SE 5.3 and 7.5 respectively) ΜG/100 g dry weight by lactobacillus bioassay and chemiluminescent assay with hog intrinsic factor respectively. the purple laver contained five types of biologically active vitamin b12 compounds (cyano-, hydroxo-, sulfito-, adenosyl- and methylcobalamin), in which the vitamin b12 coezymes (adenosyl- and methylcobalamin) comprised about 60 % of the total vitamin b12. when 9-week-old vitamin b12-deficient rats, which excreted substantial amounts of methylmalonic acid (71.7(se 20.2) μmol/d) in urine, were fed the diet supplemented with dried purple laver (10 μg/kg diet) for 20 d, urinary methylmalonic acid excretion (as an index of vitamin B12 deficiency) became undetectable and hepatic vitamin B12 (especially adenosylcobalamin) levels were significantly increased. These results indicate that vitamin B12 in dried purple laver is bioavailable to rats.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN2001352</identifier><identifier>PMID: 11430774</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Acids ; Algae ; Animals ; Bioassays ; Bioavailability ; Biological and medical sciences ; Biological Availability ; Biomarkers - urine ; Body Weight - physiology ; Cellulose ; Chemiluminescence ; Diet ; Glucose ; Hepatic vitamin B12 content ; Laboratory animals ; Lactobacillus ; Liver - metabolism ; Male ; Medical sciences ; Metabolic diseases ; Methylmalonic Acid - urine ; Nutrition ; Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) ; Porphyra yezoensis ; Purple laver ; Rats ; Rats, Wistar ; Science ; Seaweed - chemistry ; Soybeans ; Urinary methylmalonate excretion ; Urine ; Vitamin B 12 - analysis ; Vitamin B 12 - pharmacokinetics ; Vitamin B 12 Deficiency - diet therapy ; Vitamin B 12 Deficiency - metabolism ; Vitamin B12 deficiency</subject><ispartof>British journal of nutrition, 2001-06, Vol.85 (6), p.699-703</ispartof><rights>Copyright © The Nutrition Society 2001</rights><rights>2001 INIST-CNRS</rights><rights>The Nutrition Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1023446$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11430774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takenaka, Shigeo</creatorcontrib><creatorcontrib>Sugiyama, Sumi</creatorcontrib><creatorcontrib>Ebara, Shuhei</creatorcontrib><creatorcontrib>Miyamoto, Emi</creatorcontrib><creatorcontrib>Abe, Katsuo</creatorcontrib><creatorcontrib>Tamura, Yoshiyuki</creatorcontrib><creatorcontrib>Watanabe, Fumio</creatorcontrib><creatorcontrib>Tsuyama, Shingo</creatorcontrib><creatorcontrib>Nakano, Yoshihisa</creatorcontrib><title>Feeding dried purple laver (nori) to vitamin B12-deficient rats significantly improves vitamin B12 status</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>To clarify the bioavailability of vitamin B12 in lyophylized purple laver (nori; Porphyra yezoensis), total vitamin B12 and vitamin B12 analogue contents in the laver were determined, and the effects of feeding the laver to vitamin B12-deficient rats were investigated. The amount of total vitamin B12 in the dried purple laver was estimated to be 54.5 and 58.6 (SE 5.3 and 7.5 respectively) ΜG/100 g dry weight by lactobacillus bioassay and chemiluminescent assay with hog intrinsic factor respectively. the purple laver contained five types of biologically active vitamin b12 compounds (cyano-, hydroxo-, sulfito-, adenosyl- and methylcobalamin), in which the vitamin b12 coezymes (adenosyl- and methylcobalamin) comprised about 60 % of the total vitamin b12. when 9-week-old vitamin b12-deficient rats, which excreted substantial amounts of methylmalonic acid (71.7(se 20.2) μmol/d) in urine, were fed the diet supplemented with dried purple laver (10 μg/kg diet) for 20 d, urinary methylmalonic acid excretion (as an index of vitamin B12 deficiency) became undetectable and hepatic vitamin B12 (especially adenosylcobalamin) levels were significantly increased. These results indicate that vitamin B12 in dried purple laver is bioavailable to rats.</description><subject>Acids</subject><subject>Algae</subject><subject>Animals</subject><subject>Bioassays</subject><subject>Bioavailability</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Biomarkers - urine</subject><subject>Body Weight - physiology</subject><subject>Cellulose</subject><subject>Chemiluminescence</subject><subject>Diet</subject><subject>Glucose</subject><subject>Hepatic vitamin B12 content</subject><subject>Laboratory animals</subject><subject>Lactobacillus</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Methylmalonic Acid - urine</subject><subject>Nutrition</subject><subject>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</subject><subject>Porphyra yezoensis</subject><subject>Purple laver</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Science</subject><subject>Seaweed - chemistry</subject><subject>Soybeans</subject><subject>Urinary methylmalonate excretion</subject><subject>Urine</subject><subject>Vitamin B 12 - analysis</subject><subject>Vitamin B 12 - pharmacokinetics</subject><subject>Vitamin B 12 Deficiency - diet therapy</subject><subject>Vitamin B 12 Deficiency - metabolism</subject><subject>Vitamin B12 deficiency</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0s1rFDEUAPBQKnatXvwDSihFFDo235kcbXH7iVKpFy8hmcksaWcya5JZ2v_eyG5d8eIp5OWX5L3HA-AtRh8xkurk9OoLQQhTTnbADDPJKyIE2QUzhJCsMGZ8D7xK6b5sa4zUS7BXYhRJyWbAz51rfVjANnrXwuUUl72DvVm5CN-HMfoPMI9w5bMZfICnmFSt63zjXcgwmpxg8ovgS8SE3D9BPyzjuHLp7xswZZOn9Bq86Eyf3JvNug--zz_fnV1UN1_PL88-3VQNrQWpsGBWsYZRSiySzOJaGOtQzR1HRFBCRKcs6zpC2oYwS2tEKca25q3iCnND98G79bslk5-TS1kPPjWu701w45S0RIrXSqj_QqwUpjWTBR7-A-_HKYZShCZFUMkJK-hggyY7uFYvox9MfNLPrS7gaANMakzfRRMan7YOEcqYKKxaM5-ye_xzbOKDFrJ8pcX5rf72Y351d02Qvi7-eO0bM9jo24XbZoeR_j0gejsg9Bd91KZt</recordid><startdate>200106</startdate><enddate>200106</enddate><creator>Takenaka, Shigeo</creator><creator>Sugiyama, Sumi</creator><creator>Ebara, Shuhei</creator><creator>Miyamoto, Emi</creator><creator>Abe, Katsuo</creator><creator>Tamura, Yoshiyuki</creator><creator>Watanabe, Fumio</creator><creator>Tsuyama, Shingo</creator><creator>Nakano, Yoshihisa</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200106</creationdate><title>Feeding dried purple laver (nori) to vitamin B12-deficient rats significantly improves vitamin B12 status</title><author>Takenaka, Shigeo ; Sugiyama, Sumi ; Ebara, Shuhei ; Miyamoto, Emi ; Abe, Katsuo ; Tamura, Yoshiyuki ; Watanabe, Fumio ; Tsuyama, Shingo ; Nakano, Yoshihisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3862-164b94c4332b074b186abe085e50263226f9b4ff22dc24b3803311b85d95915a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Acids</topic><topic>Algae</topic><topic>Animals</topic><topic>Bioassays</topic><topic>Bioavailability</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Biomarkers - urine</topic><topic>Body Weight - physiology</topic><topic>Cellulose</topic><topic>Chemiluminescence</topic><topic>Diet</topic><topic>Glucose</topic><topic>Hepatic vitamin B12 content</topic><topic>Laboratory animals</topic><topic>Lactobacillus</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Methylmalonic Acid - urine</topic><topic>Nutrition</topic><topic>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</topic><topic>Porphyra yezoensis</topic><topic>Purple laver</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Science</topic><topic>Seaweed - chemistry</topic><topic>Soybeans</topic><topic>Urinary methylmalonate excretion</topic><topic>Urine</topic><topic>Vitamin B 12 - analysis</topic><topic>Vitamin B 12 - pharmacokinetics</topic><topic>Vitamin B 12 Deficiency - diet therapy</topic><topic>Vitamin B 12 Deficiency - metabolism</topic><topic>Vitamin B12 deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takenaka, Shigeo</creatorcontrib><creatorcontrib>Sugiyama, Sumi</creatorcontrib><creatorcontrib>Ebara, Shuhei</creatorcontrib><creatorcontrib>Miyamoto, Emi</creatorcontrib><creatorcontrib>Abe, Katsuo</creatorcontrib><creatorcontrib>Tamura, Yoshiyuki</creatorcontrib><creatorcontrib>Watanabe, Fumio</creatorcontrib><creatorcontrib>Tsuyama, Shingo</creatorcontrib><creatorcontrib>Nakano, Yoshihisa</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takenaka, Shigeo</au><au>Sugiyama, Sumi</au><au>Ebara, Shuhei</au><au>Miyamoto, Emi</au><au>Abe, Katsuo</au><au>Tamura, Yoshiyuki</au><au>Watanabe, Fumio</au><au>Tsuyama, Shingo</au><au>Nakano, Yoshihisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Feeding dried purple laver (nori) to vitamin B12-deficient rats significantly improves vitamin B12 status</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2001-06</date><risdate>2001</risdate><volume>85</volume><issue>6</issue><spage>699</spage><epage>703</epage><pages>699-703</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>To clarify the bioavailability of vitamin B12 in lyophylized purple laver (nori; Porphyra yezoensis), total vitamin B12 and vitamin B12 analogue contents in the laver were determined, and the effects of feeding the laver to vitamin B12-deficient rats were investigated. The amount of total vitamin B12 in the dried purple laver was estimated to be 54.5 and 58.6 (SE 5.3 and 7.5 respectively) ΜG/100 g dry weight by lactobacillus bioassay and chemiluminescent assay with hog intrinsic factor respectively. the purple laver contained five types of biologically active vitamin b12 compounds (cyano-, hydroxo-, sulfito-, adenosyl- and methylcobalamin), in which the vitamin b12 coezymes (adenosyl- and methylcobalamin) comprised about 60 % of the total vitamin b12. when 9-week-old vitamin b12-deficient rats, which excreted substantial amounts of methylmalonic acid (71.7(se 20.2) μmol/d) in urine, were fed the diet supplemented with dried purple laver (10 μg/kg diet) for 20 d, urinary methylmalonic acid excretion (as an index of vitamin B12 deficiency) became undetectable and hepatic vitamin B12 (especially adenosylcobalamin) levels were significantly increased. These results indicate that vitamin B12 in dried purple laver is bioavailable to rats.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>11430774</pmid><doi>10.1079/BJN2001352</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Algae Animals Bioassays Bioavailability Biological and medical sciences Biological Availability Biomarkers - urine Body Weight - physiology Cellulose Chemiluminescence Diet Glucose Hepatic vitamin B12 content Laboratory animals Lactobacillus Liver - metabolism Male Medical sciences Metabolic diseases Methylmalonic Acid - urine Nutrition Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Porphyra yezoensis Purple laver Rats Rats, Wistar Science Seaweed - chemistry Soybeans Urinary methylmalonate excretion Urine Vitamin B 12 - analysis Vitamin B 12 - pharmacokinetics Vitamin B 12 Deficiency - diet therapy Vitamin B 12 Deficiency - metabolism Vitamin B12 deficiency |
| title | Feeding dried purple laver (nori) to vitamin B12-deficient rats significantly improves vitamin B12 status |
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