Synthesis of potential aldose reductase inhibitors based on minimal pharmacophore requirements

A series of 17 compounds were synthesized based on the premise that the minimal pharmacophore for aldose reductase inhibition requires the presence of both an aryl group and polar group connected by a linking structure. Three groups of compounds were synthesized, the first possessing an aniline‐4‐(2...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2001-06, Vol.53 (6), p.831-839
Hauptverfasser:	Schlitzer, Martin, Rodriguez, Labaniel, Kador, Peter F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Reductase - antagonists & inhibitors Biological and medical sciences Carboxylic Acids - chemistry Drug Design Enzyme Inhibitors - chemical synthesis Esters General pharmacology Humans Medical sciences Methylation Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Structure-Activity Relationship
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