Comparative analyses of the pigment-aggregating and -dispersing actions of MCH on fish chromatophores
In melanophores of the peppered catfish and the Nile tilapia, melanin-concentrating hormone (MCH) at low doses (
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| Veröffentlicht in: | Comparative biochemistry and physiology. Toxicology & pharmacology 2001-06, Vol.129 (2), p.75-84 |
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| container_title | Comparative biochemistry and physiology. Toxicology & pharmacology |
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| creator | Oshima, Noriko Nakamaru, Naohiko Araki, Sachiko Sugimoto, Masazumi |
| description | In melanophores of the peppered catfish and the Nile tilapia, melanin-concentrating hormone (MCH) at low doses ( |
| doi_str_mv | 10.1016/S1532-0456(01)00187-9 |
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2+ ions. By contrast, medaka melanophores responded to MCH only by pigment aggregation, even at the highest concentration employed (10 μM). Since it is known that medaka melanophores possess specific receptors for α-melanophore-stimulating hormone (α-MSH), the possibility that interaction between MSH receptors and MCH at high doses in the presence of Ca
2+ might cause pigment dispersion is ruled out. Cyclic MCH analogs, MCH (1–14) and MCH (5–17), failed to induce pigment dispersion, whereas they induced aggregation of melanin granules. These results suggest that another type of MCH receptor that mediates pigment dispersion is present in catfish and tilapia melanophores, and that intact MCH may be the only molecule that can bind to these receptors. Determinations of cAMP content in melanophores, which were isolated from the skin of three fish species and treated with 10 nM or 10 μM MCH, indicate that MCH receptors mediating aggregation may be coupled with Gi protein, whereas MCH receptors that mediate dispersion may be linked to Gs. The response of erythrophores, xanthophores and leucophores to MCH at various concentrations was also examined, and the results suggest that the distribution patterns of the two types of MCH receptors may differ among fish species and among types of chromatophore in the same fish.</description><identifier>ISSN: 1532-0456</identifier><identifier>EISSN: 1878-1659</identifier><identifier>DOI: 10.1016/S1532-0456(01)00187-9</identifier><identifier>PMID: 11423380</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Brackish ; Calcium - pharmacology ; cAMP ; Chromatophores ; Chromatophores - drug effects ; Chromatophores - physiology ; Cyclic AMP - metabolism ; Dose-Response Relationship, Drug ; Erythrophores ; Female ; Fish ; Fishes - physiology ; Freshwater ; Hypothalamic Hormones - pharmacology ; In Vitro Techniques ; Kinetics ; Leucophores ; Male ; Marine ; Melanin-concentrating hormone (MCH) ; Melanin-concentrating hormone (MCH) receptor ; Melanins - metabolism ; Melanins - pharmacology ; Melanophores ; Melanophores - drug effects ; Melanophores - physiology ; Pisces ; Pituitary Hormones - pharmacology ; Xanthophores</subject><ispartof>Comparative biochemistry and physiology. Toxicology & pharmacology, 2001-06, Vol.129 (2), p.75-84</ispartof><rights>2001 Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-cea8d458f7b01cf69ea3071a30ab6539cd264856e00d0cfb6c66ecd700dbbb373</citedby><cites>FETCH-LOGICAL-c392t-cea8d458f7b01cf69ea3071a30ab6539cd264856e00d0cfb6c66ecd700dbbb373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1532-0456(01)00187-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11423380$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oshima, Noriko</creatorcontrib><creatorcontrib>Nakamaru, Naohiko</creatorcontrib><creatorcontrib>Araki, Sachiko</creatorcontrib><creatorcontrib>Sugimoto, Masazumi</creatorcontrib><title>Comparative analyses of the pigment-aggregating and -dispersing actions of MCH on fish chromatophores</title><title>Comparative biochemistry and physiology. Toxicology & pharmacology</title><addtitle>Comp Biochem Physiol C Toxicol Pharmacol</addtitle><description>In melanophores of the peppered catfish and the Nile tilapia, melanin-concentrating hormone (MCH) at low doses (<1 μM) induced pigment aggregation, and the aggregated state was maintained in the presence of MCH. However, at higher MCH concentrations (such as 1 and 10 μM), pigment aggregation was immediately followed by some re-dispersion, even in the continued presence of MCH, which led to an apparent decrease in aggregation. This pigment-dispersing activity at higher concentrations of MCH required extracellular Ca
2+ ions. By contrast, medaka melanophores responded to MCH only by pigment aggregation, even at the highest concentration employed (10 μM). Since it is known that medaka melanophores possess specific receptors for α-melanophore-stimulating hormone (α-MSH), the possibility that interaction between MSH receptors and MCH at high doses in the presence of Ca
2+ might cause pigment dispersion is ruled out. Cyclic MCH analogs, MCH (1–14) and MCH (5–17), failed to induce pigment dispersion, whereas they induced aggregation of melanin granules. These results suggest that another type of MCH receptor that mediates pigment dispersion is present in catfish and tilapia melanophores, and that intact MCH may be the only molecule that can bind to these receptors. Determinations of cAMP content in melanophores, which were isolated from the skin of three fish species and treated with 10 nM or 10 μM MCH, indicate that MCH receptors mediating aggregation may be coupled with Gi protein, whereas MCH receptors that mediate dispersion may be linked to Gs. The response of erythrophores, xanthophores and leucophores to MCH at various concentrations was also examined, and the results suggest that the distribution patterns of the two types of MCH receptors may differ among fish species and among types of chromatophore in the same fish.</description><subject>Animals</subject><subject>Brackish</subject><subject>Calcium - pharmacology</subject><subject>cAMP</subject><subject>Chromatophores</subject><subject>Chromatophores - drug effects</subject><subject>Chromatophores - physiology</subject><subject>Cyclic AMP - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Erythrophores</subject><subject>Female</subject><subject>Fish</subject><subject>Fishes - physiology</subject><subject>Freshwater</subject><subject>Hypothalamic Hormones - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Kinetics</subject><subject>Leucophores</subject><subject>Male</subject><subject>Marine</subject><subject>Melanin-concentrating hormone (MCH)</subject><subject>Melanin-concentrating hormone (MCH) receptor</subject><subject>Melanins - metabolism</subject><subject>Melanins - pharmacology</subject><subject>Melanophores</subject><subject>Melanophores - drug effects</subject><subject>Melanophores - physiology</subject><subject>Pisces</subject><subject>Pituitary Hormones - pharmacology</subject><subject>Xanthophores</subject><issn>1532-0456</issn><issn>1878-1659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtP3DAUha0KVAboTyjKCpVF4DqOHWdVVREUJCoWLWvLsW8yRpM4tTMj8e_reVQsZ3Mf0nfulc4h5CuFWwpU3P2mnBU5lFx8A3oDQGWV15_IInWZU8HrkzT_R87IeYxvAMBLKj6TM0rLgjEJC4KNHyYd9Ow2mOlRr94jxsx32bzEbHL9gOOc674P2Cdm7BNjs9y6OGGIu93Mzo87ya_mMfNj1rm4zMwy-EHPflr6gPGSnHZ6FfHLoV-Q14f7P81j_vzy86n58ZwbVhdzblBLW3LZVS1Q04kaNYOKpqJbwVltbCFKyQUCWDBdK4wQaGyV1rZtWcUuyPX-7hT83zXGWQ0uGlyt9Ih-HVUFNZcs2XIMpJJKUYgigXwPmuBjDNipKbhBh3dFQW2DULsg1NZlBVTtglB10l0dHqzbAe2H6uB8Ar7vAUx-bBwGFY3D0aB1Ac2srHdHXvwDeruZGQ</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>Oshima, Noriko</creator><creator>Nakamaru, Naohiko</creator><creator>Araki, Sachiko</creator><creator>Sugimoto, Masazumi</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>20010601</creationdate><title>Comparative analyses of the pigment-aggregating and -dispersing actions of MCH on fish chromatophores</title><author>Oshima, Noriko ; Nakamaru, Naohiko ; Araki, Sachiko ; Sugimoto, Masazumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-cea8d458f7b01cf69ea3071a30ab6539cd264856e00d0cfb6c66ecd700dbbb373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Brackish</topic><topic>Calcium - pharmacology</topic><topic>cAMP</topic><topic>Chromatophores</topic><topic>Chromatophores - drug effects</topic><topic>Chromatophores - physiology</topic><topic>Cyclic AMP - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Erythrophores</topic><topic>Female</topic><topic>Fish</topic><topic>Fishes - physiology</topic><topic>Freshwater</topic><topic>Hypothalamic Hormones - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Kinetics</topic><topic>Leucophores</topic><topic>Male</topic><topic>Marine</topic><topic>Melanin-concentrating hormone (MCH)</topic><topic>Melanin-concentrating hormone (MCH) receptor</topic><topic>Melanins - metabolism</topic><topic>Melanins - pharmacology</topic><topic>Melanophores</topic><topic>Melanophores - drug effects</topic><topic>Melanophores - physiology</topic><topic>Pisces</topic><topic>Pituitary Hormones - pharmacology</topic><topic>Xanthophores</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oshima, Noriko</creatorcontrib><creatorcontrib>Nakamaru, Naohiko</creatorcontrib><creatorcontrib>Araki, Sachiko</creatorcontrib><creatorcontrib>Sugimoto, Masazumi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Comparative biochemistry and physiology. Toxicology & pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oshima, Noriko</au><au>Nakamaru, Naohiko</au><au>Araki, Sachiko</au><au>Sugimoto, Masazumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative analyses of the pigment-aggregating and -dispersing actions of MCH on fish chromatophores</atitle><jtitle>Comparative biochemistry and physiology. Toxicology & pharmacology</jtitle><addtitle>Comp Biochem Physiol C Toxicol Pharmacol</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>129</volume><issue>2</issue><spage>75</spage><epage>84</epage><pages>75-84</pages><issn>1532-0456</issn><eissn>1878-1659</eissn><abstract>In melanophores of the peppered catfish and the Nile tilapia, melanin-concentrating hormone (MCH) at low doses (<1 μM) induced pigment aggregation, and the aggregated state was maintained in the presence of MCH. However, at higher MCH concentrations (such as 1 and 10 μM), pigment aggregation was immediately followed by some re-dispersion, even in the continued presence of MCH, which led to an apparent decrease in aggregation. This pigment-dispersing activity at higher concentrations of MCH required extracellular Ca
2+ ions. By contrast, medaka melanophores responded to MCH only by pigment aggregation, even at the highest concentration employed (10 μM). Since it is known that medaka melanophores possess specific receptors for α-melanophore-stimulating hormone (α-MSH), the possibility that interaction between MSH receptors and MCH at high doses in the presence of Ca
2+ might cause pigment dispersion is ruled out. Cyclic MCH analogs, MCH (1–14) and MCH (5–17), failed to induce pigment dispersion, whereas they induced aggregation of melanin granules. These results suggest that another type of MCH receptor that mediates pigment dispersion is present in catfish and tilapia melanophores, and that intact MCH may be the only molecule that can bind to these receptors. Determinations of cAMP content in melanophores, which were isolated from the skin of three fish species and treated with 10 nM or 10 μM MCH, indicate that MCH receptors mediating aggregation may be coupled with Gi protein, whereas MCH receptors that mediate dispersion may be linked to Gs. The response of erythrophores, xanthophores and leucophores to MCH at various concentrations was also examined, and the results suggest that the distribution patterns of the two types of MCH receptors may differ among fish species and among types of chromatophore in the same fish.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11423380</pmid><doi>10.1016/S1532-0456(01)00187-9</doi><tpages>10</tpages></addata></record> |
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| ispartof | Comparative biochemistry and physiology. Toxicology & pharmacology, 2001-06, Vol.129 (2), p.75-84 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Brackish Calcium - pharmacology cAMP Chromatophores Chromatophores - drug effects Chromatophores - physiology Cyclic AMP - metabolism Dose-Response Relationship, Drug Erythrophores Female Fish Fishes - physiology Freshwater Hypothalamic Hormones - pharmacology In Vitro Techniques Kinetics Leucophores Male Marine Melanin-concentrating hormone (MCH) Melanin-concentrating hormone (MCH) receptor Melanins - metabolism Melanins - pharmacology Melanophores Melanophores - drug effects Melanophores - physiology Pisces Pituitary Hormones - pharmacology Xanthophores |
| title | Comparative analyses of the pigment-aggregating and -dispersing actions of MCH on fish chromatophores |
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