A novel MVMp-based vector system specifically designed to reduce the risk of replication-competent virus generation by homologous recombination

Recent work highlights the potential usefulness of MVM-based vectors as selective vehicles for cancer gene therapy (Dupont et al, Gene Therapy, 2000; 7: 790-796). To implement this strategy, however, it is necessary to develop optimized methods for producing high-titer, helper-free parvovirus stocks...

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Veröffentlicht in:	Gene therapy 2001-06, Vol.8 (12), p.921-929
Hauptverfasser:	DUPONT, F, KARIM, A, DUMON, J-C, MINE, N, AVALOSSE, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotechnology Expression vectors Fundamental and applied biological sciences. Psychology Gene therapy Genetic code Genetic Engineering Genetic Therapy - methods Genetic Vectors Genome, Viral Genomes Health. Pharmaceutical industry Helper viruses Homologous recombination Homology Humans Industrial applications and implications. Economical aspects Minute Virus of Mice - genetics Neoplasms - therapy Nucleotide sequence Packaging Parvoviruses Recombinants Replication Secondary infection Sequence Homology Tumor Cells, Cultured Virus Replication Viruses
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