T lymphocytes in the synovial fluid of patients with active rheumatoid arthritis display CD134-OX40 surface antigen
To assess the percentage of T lymphocytes, bearing CD134, a member of the TNF receptor superfamily, primarily found on autoreactive CD4+ T cells in the peripheral blood (PB) and synovial fluid (SF) of rheumatoid arthritis (RA) patients. The surface expression of CD134 on SF and PB mononuclear cells...
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| Veröffentlicht in: | Clinical and experimental rheumatology 2001-05, Vol.19 (3), p.317-320 |
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| container_title | Clinical and experimental rheumatology |
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| creator | GIACOMELLI, R PASSACANTANDO, A PERRICONE, R PARZANESE, I RASCENTE, M MINISOLA, G TONIETTI, G |
| description | To assess the percentage of T lymphocytes, bearing CD134, a member of the TNF receptor superfamily, primarily found on autoreactive CD4+ T cells in the peripheral blood (PB) and synovial fluid (SF) of rheumatoid arthritis (RA) patients.
The surface expression of CD134 on SF and PB mononuclear cells was performed by flow cytometry in 25 RA patients and correlated to the disease activity.
CD134 expression on CD3+, CD4+, CD8+ and CD25+ cells was higher in SF than in PB of RA patients (P < 0.001). No differences were observed in the percentage of CD134+/CD4+ T lymphocytes in the PB of RA patients and controls. Patients with active RA had significantly higher percentage of CD3+/CD134+, CD4+/CD 134+, CD8+/CD134+ and CD25+/CD 134+ than those with inactive disease.
These findings suggest that CD134+ T cells are involved in the immunopathological process of RA synovitis, maybe mirroring some other autoimmune disease in which autoreactive T cell infiltrating the target tissues largely coexpress CD134. |
| format | Article |
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The surface expression of CD134 on SF and PB mononuclear cells was performed by flow cytometry in 25 RA patients and correlated to the disease activity.
CD134 expression on CD3+, CD4+, CD8+ and CD25+ cells was higher in SF than in PB of RA patients (P < 0.001). No differences were observed in the percentage of CD134+/CD4+ T lymphocytes in the PB of RA patients and controls. Patients with active RA had significantly higher percentage of CD3+/CD134+, CD4+/CD 134+, CD8+/CD134+ and CD25+/CD 134+ than those with inactive disease.
These findings suggest that CD134+ T cells are involved in the immunopathological process of RA synovitis, maybe mirroring some other autoimmune disease in which autoreactive T cell infiltrating the target tissues largely coexpress CD134.</description><identifier>ISSN: 0392-856X</identifier><identifier>EISSN: 1593-098X</identifier><identifier>PMID: 11407087</identifier><language>eng</language><publisher>Pisa: Clinical and Experimental Rheumatology</publisher><subject>Adolescent ; Adult ; Aged ; Antigens, Surface - immunology ; Arthritis, Rheumatoid - immunology ; Biological and medical sciences ; CD3 Complex - analysis ; CD4 Antigens - analysis ; CD8 Antigens - analysis ; Diseases of the osteoarticular system ; Female ; Flow Cytometry ; Humans ; Immunophenotyping ; Inflammatory joint diseases ; Male ; Medical sciences ; Middle Aged ; Receptors, Interleukin-2 - analysis ; Receptors, OX40 ; Receptors, Tumor Necrosis Factor ; Synovial Fluid - cytology ; Synovial Fluid - immunology ; T-Lymphocytes - chemistry ; T-Lymphocytes - immunology ; Tumor Necrosis Factor Receptor Superfamily, Member 7 - analysis</subject><ispartof>Clinical and experimental rheumatology, 2001-05, Vol.19 (3), p.317-320</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1074008$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11407087$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GIACOMELLI, R</creatorcontrib><creatorcontrib>PASSACANTANDO, A</creatorcontrib><creatorcontrib>PERRICONE, R</creatorcontrib><creatorcontrib>PARZANESE, I</creatorcontrib><creatorcontrib>RASCENTE, M</creatorcontrib><creatorcontrib>MINISOLA, G</creatorcontrib><creatorcontrib>TONIETTI, G</creatorcontrib><title>T lymphocytes in the synovial fluid of patients with active rheumatoid arthritis display CD134-OX40 surface antigen</title><title>Clinical and experimental rheumatology</title><addtitle>Clin Exp Rheumatol</addtitle><description>To assess the percentage of T lymphocytes, bearing CD134, a member of the TNF receptor superfamily, primarily found on autoreactive CD4+ T cells in the peripheral blood (PB) and synovial fluid (SF) of rheumatoid arthritis (RA) patients.
The surface expression of CD134 on SF and PB mononuclear cells was performed by flow cytometry in 25 RA patients and correlated to the disease activity.
CD134 expression on CD3+, CD4+, CD8+ and CD25+ cells was higher in SF than in PB of RA patients (P < 0.001). No differences were observed in the percentage of CD134+/CD4+ T lymphocytes in the PB of RA patients and controls. Patients with active RA had significantly higher percentage of CD3+/CD134+, CD4+/CD 134+, CD8+/CD134+ and CD25+/CD 134+ than those with inactive disease.
These findings suggest that CD134+ T cells are involved in the immunopathological process of RA synovitis, maybe mirroring some other autoimmune disease in which autoreactive T cell infiltrating the target tissues largely coexpress CD134.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antigens, Surface - immunology</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Biological and medical sciences</subject><subject>CD3 Complex - analysis</subject><subject>CD4 Antigens - analysis</subject><subject>CD8 Antigens - analysis</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Inflammatory joint diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Receptors, Interleukin-2 - analysis</subject><subject>Receptors, OX40</subject><subject>Receptors, Tumor Necrosis Factor</subject><subject>Synovial Fluid - cytology</subject><subject>Synovial Fluid - immunology</subject><subject>T-Lymphocytes - chemistry</subject><subject>T-Lymphocytes - immunology</subject><subject>Tumor Necrosis Factor Receptor Superfamily, Member 7 - analysis</subject><issn>0392-856X</issn><issn>1593-098X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0EtLw0AYheEgiq3VvyCzEHeBb26ZZCn1CoVuKnQXvsxMzEhuzkwq-fcWrLg6m4ezeM-SJZUFT6HI9-fJEnjB0lxm-0VyFcInAMtkpi6TBaUCFORqmYQdaedubAY9RxuI60lsLAlzPxwctqRuJ2fIUJMRo7N9DOTbxYagju5giW_s1GEcjgR9bLyLLhDjwtjiTNaPlIt0uxdAwuRr1JZgH92H7a-TixrbYG9Ou0ren59269d0s315Wz9s0pHxLKbKVmDqnOYgJDKKBrTRIsutVLURvAYuKoRMKwWKWkTBjawoo5oKJVmOfJXc__6OfviabIhl54K2bYu9HaZQKiikAsaO8PYEp6qzphy969DP5V-mI7g7AQwa29pjr134d6AEQM5_AMSicl8</recordid><startdate>20010501</startdate><enddate>20010501</enddate><creator>GIACOMELLI, R</creator><creator>PASSACANTANDO, A</creator><creator>PERRICONE, R</creator><creator>PARZANESE, I</creator><creator>RASCENTE, M</creator><creator>MINISOLA, G</creator><creator>TONIETTI, G</creator><general>Clinical and Experimental Rheumatology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20010501</creationdate><title>T lymphocytes in the synovial fluid of patients with active rheumatoid arthritis display CD134-OX40 surface antigen</title><author>GIACOMELLI, R ; PASSACANTANDO, A ; PERRICONE, R ; PARZANESE, I ; RASCENTE, M ; MINISOLA, G ; TONIETTI, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p236t-7eb0df818045a21ad0cdc468e57fd43f034ba06c77071eaa43d5b121c147528a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antigens, Surface - immunology</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Biological and medical sciences</topic><topic>CD3 Complex - analysis</topic><topic>CD4 Antigens - analysis</topic><topic>CD8 Antigens - analysis</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>Inflammatory joint diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Receptors, Interleukin-2 - analysis</topic><topic>Receptors, OX40</topic><topic>Receptors, Tumor Necrosis Factor</topic><topic>Synovial Fluid - cytology</topic><topic>Synovial Fluid - immunology</topic><topic>T-Lymphocytes - chemistry</topic><topic>T-Lymphocytes - immunology</topic><topic>Tumor Necrosis Factor Receptor Superfamily, Member 7 - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GIACOMELLI, R</creatorcontrib><creatorcontrib>PASSACANTANDO, A</creatorcontrib><creatorcontrib>PERRICONE, R</creatorcontrib><creatorcontrib>PARZANESE, I</creatorcontrib><creatorcontrib>RASCENTE, M</creatorcontrib><creatorcontrib>MINISOLA, G</creatorcontrib><creatorcontrib>TONIETTI, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GIACOMELLI, R</au><au>PASSACANTANDO, A</au><au>PERRICONE, R</au><au>PARZANESE, I</au><au>RASCENTE, M</au><au>MINISOLA, G</au><au>TONIETTI, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T lymphocytes in the synovial fluid of patients with active rheumatoid arthritis display CD134-OX40 surface antigen</atitle><jtitle>Clinical and experimental rheumatology</jtitle><addtitle>Clin Exp Rheumatol</addtitle><date>2001-05-01</date><risdate>2001</risdate><volume>19</volume><issue>3</issue><spage>317</spage><epage>320</epage><pages>317-320</pages><issn>0392-856X</issn><eissn>1593-098X</eissn><abstract>To assess the percentage of T lymphocytes, bearing CD134, a member of the TNF receptor superfamily, primarily found on autoreactive CD4+ T cells in the peripheral blood (PB) and synovial fluid (SF) of rheumatoid arthritis (RA) patients.
The surface expression of CD134 on SF and PB mononuclear cells was performed by flow cytometry in 25 RA patients and correlated to the disease activity.
CD134 expression on CD3+, CD4+, CD8+ and CD25+ cells was higher in SF than in PB of RA patients (P < 0.001). No differences were observed in the percentage of CD134+/CD4+ T lymphocytes in the PB of RA patients and controls. Patients with active RA had significantly higher percentage of CD3+/CD134+, CD4+/CD 134+, CD8+/CD134+ and CD25+/CD 134+ than those with inactive disease.
These findings suggest that CD134+ T cells are involved in the immunopathological process of RA synovitis, maybe mirroring some other autoimmune disease in which autoreactive T cell infiltrating the target tissues largely coexpress CD134.</abstract><cop>Pisa</cop><pub>Clinical and Experimental Rheumatology</pub><pmid>11407087</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Clinical and experimental rheumatology, 2001-05, Vol.19 (3), p.317-320 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Antigens, Surface - immunology Arthritis, Rheumatoid - immunology Biological and medical sciences CD3 Complex - analysis CD4 Antigens - analysis CD8 Antigens - analysis Diseases of the osteoarticular system Female Flow Cytometry Humans Immunophenotyping Inflammatory joint diseases Male Medical sciences Middle Aged Receptors, Interleukin-2 - analysis Receptors, OX40 Receptors, Tumor Necrosis Factor Synovial Fluid - cytology Synovial Fluid - immunology T-Lymphocytes - chemistry T-Lymphocytes - immunology Tumor Necrosis Factor Receptor Superfamily, Member 7 - analysis |
| title | T lymphocytes in the synovial fluid of patients with active rheumatoid arthritis display CD134-OX40 surface antigen |
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