Molecular Remission Following High-Dose Hydroxyurea and Fludarabine Plus Cytarabine in a Patient with Simultaneous Acute Myeloid Leukemia and Low-Grade Lymphoma
The occurrence of acute myeloid leukemia (AML) as a secondary tumor has been frequently reported in patients who received various chemotherapy regimens for hematologic malignancies wile the concomitant development of chronic lymphoproliferative diseases (CLD) and AML in previously untreated patients...
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| Veröffentlicht in: | Leukemia & lymphoma 2001-02, Vol.40 (5-6), p.671-674 |
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| container_issue | 5-6 |
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| container_title | Leukemia & lymphoma |
| container_volume | 40 |
| creator | Montefusco, E. Fazi, F. Cordone, I. Ariola, C. Nanni, M. Spadea, A. Aloe Spiriti, M. A. Fenu, S. Mandelli, F. Petti, M. C. |
| description | The occurrence of acute myeloid leukemia (AML) as a secondary tumor has been frequently reported in patients who received various chemotherapy regimens for hematologic malignancies wile the concomitant development of chronic lymphoproliferative diseases (CLD) and AML in previously untreated patients is extremely rare. We report a case with an apparently spontaneous occurrence of AML and non Hodgkin low-grade lymphoma diagnosed by immunological, cytogenetical and molecular analyses. In particular genetic studies allowed to identify the coexistence of a clonal lymphoid population and a myeloid blast component characterized by inv(16) marker and CBFbeta-MYH11 gene fusion. Complete remission of AML and the CLD was obtained following high doses of hydroxyurea and two consolidation cycles of fludarabine plus intermediate dose cytarabine. |
| doi_str_mv | 10.3109/10428190109097666 |
| format | Article |
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A.</creatorcontrib><creatorcontrib>Fenu, S.</creatorcontrib><creatorcontrib>Mandelli, F.</creatorcontrib><creatorcontrib>Petti, M. C.</creatorcontrib><title>Molecular Remission Following High-Dose Hydroxyurea and Fludarabine Plus Cytarabine in a Patient with Simultaneous Acute Myeloid Leukemia and Low-Grade Lymphoma</title><title>Leukemia & lymphoma</title><addtitle>Leuk Lymphoma</addtitle><description>The occurrence of acute myeloid leukemia (AML) as a secondary tumor has been frequently reported in patients who received various chemotherapy regimens for hematologic malignancies wile the concomitant development of chronic lymphoproliferative diseases (CLD) and AML in previously untreated patients is extremely rare. We report a case with an apparently spontaneous occurrence of AML and non Hodgkin low-grade lymphoma diagnosed by immunological, cytogenetical and molecular analyses. In particular genetic studies allowed to identify the coexistence of a clonal lymphoid population and a myeloid blast component characterized by inv(16) marker and CBFbeta-MYH11 gene fusion. Complete remission of AML and the CLD was obtained following high doses of hydroxyurea and two consolidation cycles of fludarabine plus intermediate dose cytarabine.</description><subject>Acute Disease</subject><subject>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</subject><subject>Cytarabine - administration & dosage</subject><subject>Humans</subject><subject>Hydroxyurea - administration & dosage</subject><subject>Leukemia, Myeloid - drug therapy</subject><subject>Leukemia, Myeloid - pathology</subject><subject>Lymphoma - drug therapy</subject><subject>Lymphoma - pathology</subject><subject>Neoplasms, Multiple Primary</subject><subject>Remission Induction</subject><subject>Vidarabine - administration & dosage</subject><subject>Vidarabine - analogs & derivatives</subject><issn>1042-8194</issn><issn>1029-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxi0EoqXwAFyQT9wCtpPYiThVC9tFSkXV9h5N4knj4sSLHWubt-FRm1UWcUDiNDPSb7758xHynrNPKWflZ84yUfCSLTkrlZTyBTnnTJSJyFj68phnIlmA7Iy8CeGRMZaXUrwmZ5xnQuYZOye_r53FNlrw9BYHE4JxI906a93BjA90Zx765KsLSHez9u5pjh6Bwqjp1kYNHhozIr2xMdDNPP2pzUiB3sBkcJzowUw9vTNDtBOM6Bbyso0T0usZrTOaVhh_LpNX1codkisPGmk1D_veDfCWvOrABnx3ihfkfvvtfrNLqh9X3zeXVdKmWTklomsBO2BNI_O2a3LFS1kIpQumhNAgCqlUkxUg8gZ1mkollo81XOVt2nVKpRfk4yq79-5XxDDVyzNatHbduVaszCUTR5CvYOtdCB67eu_NAH6uOauPrtT_uLL0fDiJx2ZA_bfjZMMCfFkBM3bOD9Aj2KlvwWP96KIfl8P_I_8MG2uceA</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>Montefusco, E.</creator><creator>Fazi, F.</creator><creator>Cordone, I.</creator><creator>Ariola, C.</creator><creator>Nanni, M.</creator><creator>Spadea, A.</creator><creator>Aloe Spiriti, M. 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| subjects | Acute Disease Antineoplastic Combined Chemotherapy Protocols - administration & dosage Cytarabine - administration & dosage Humans Hydroxyurea - administration & dosage Leukemia, Myeloid - drug therapy Leukemia, Myeloid - pathology Lymphoma - drug therapy Lymphoma - pathology Neoplasms, Multiple Primary Remission Induction Vidarabine - administration & dosage Vidarabine - analogs & derivatives |
| title | Molecular Remission Following High-Dose Hydroxyurea and Fludarabine Plus Cytarabine in a Patient with Simultaneous Acute Myeloid Leukemia and Low-Grade Lymphoma |
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