Local Plasminogen Activator Inhibitor Type 1 Overexpression in Rat Carotid Artery Enhances Thrombosis and Endothelial Regeneration While Inhibiting Intimal Thickening

ABSTRACTElevated levels of plasminogen activator inhibitor type 1 (PAI-1) are found in advanced atherosclerotic plaque compared with normal vessel and may contribute to plaque progression and complications associated with plaque rupture. Increased expression of PAI-1 probably contributes to the thro...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2000-03, Vol.20 (3), p.853-859
Hauptverfasser:	Hasenstab, David, Lea, Holly, Clowes, Alexander W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blotting, Northern Cardiology. Vascular system Carotid Arteries - chemistry Carotid Arteries - pathology Carotid Artery Injuries - pathology Carotid Artery Injuries - physiopathology Disease Models, Animal Endothelium, Vascular - pathology Endothelium, Vascular - physiopathology Endothelium, Vascular - ultrastructure Fibrinolysis - physiology Gene Expression - physiology Genetic Vectors Medical sciences Microscopy, Electron, Scanning Plasminogen Activator Inhibitor 1 - analysis Plasminogen Activator Inhibitor 1 - genetics Rats Retroviridae - genetics RNA, Messenger - analysis Thrombosis - physiopathology Tunica Intima - pathology Tunica Intima - physiopathology Tunica Intima - ultrastructure
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