Menstrual cycle-specific inhibition of endometrial stromal cell proliferation by oncostatin M
We have investigated the possible roles of oncostatin M (OSM), which is a member of the interleukin-6 family of cytokines, in endometrial and endometriotic stromal cell growth. Endometrial and endometriotic stromal cells were collected from the uterus or ovarian chocolate cysts. We observed the expr...
Gespeichert in:
| Veröffentlicht in: | Molecular human reproduction 2001-07, Vol.7 (7), p.665-670 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 670 |
|---|---|
| container_issue | 7 |
| container_start_page | 665 |
| container_title | Molecular human reproduction |
| container_volume | 7 |
| creator | Ohata, Yorie Harada, Tasuku Fujii, Akiko Yoshida, Souichi Iwabe, Tomio Terakawa, Naoki |
| description | We have investigated the possible roles of oncostatin M (OSM), which is a member of the interleukin-6 family of cytokines, in endometrial and endometriotic stromal cell growth. Endometrial and endometriotic stromal cells were collected from the uterus or ovarian chocolate cysts. We observed the expression of mRNA transcripts for OSM, OSM receptor subunit β, leukaemia inhibitory factor receptor subunit (LIFR), and glycoprotein 130 in endometrial and endometriotic stromal cells. We also examined the effects of OSM (0–50 ng/ml) and LIF (0–10 ng/ml) on endometrial and endometriotic stromal cell proliferation and evaluated the effects of OSM on endometrial stromal cell differentiation. The presence of 10–50 ng/ml OSM significantly suppressed endometrial stromal cell growth in secretory phase tissue but not in proliferative phase tissue. In contrast, stromal cells in endometriotic tissues were resistant to the inhibitory effects of OSM. Addition of LIF did not influence the growth of endometrial stromal cells. We also showed that 10 ng/ml OSM stimulated markers of differentiation causing increased prolactin secretion and cyclooxygenase-2 gene expression in endometrial stromal cells from the secretory phase. These results suggest that OSM may play a pivotal role in regulating the growth and differentiation of endometrial cells. Endometriotic cells may behave differently from normal endometrial cells in terms of the inhibitory response to OSM. |
| doi_str_mv | 10.1093/molehr/7.7.665 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70955632</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>374211281</sourcerecordid><originalsourceid>FETCH-LOGICAL-c551t-e734506cd74603babbd315d08bb5c56229d9cb72bd542befcde2b0bc98aa56973</originalsourceid><addsrcrecordid>eNqF0c9rFDEUB_BQlLbWXj2WQcTbbPM7m6MWtUqXiqgUQUKSeUPTziRrMgPuf2_WXVR6kRzyQj55vPBF6BnBC4I1Ox_TALf5XC3UQkpxgI4Jl7ilHKtHtWa11pqrI_SklDuMiaJieYiOCOEUM42P0fcVxDLl2Q6N3_gB2rIGH_rgmxBvgwtTSLFJfQOxSyNMOVRYfRq3D2AYmnVOQ-gh29_SbZoUfSpTPcZm9RQ97u1Q4HS_n6Avb998vrhsr67fvb94ddV6IcjUgmJcYOk7VYdnzjrXMSI6vHROeCEp1Z32TlHXCU4d9L4D6rDzemmtkFqxE_Ry17dO82OGMpkxlO14NkKai1FYCyEZ_S-kmHNGNa7w-QN4l-Yc6ycMpYJiJbmuaLFDPqdSMvRmncNo88YQbLbxmF08RtVV46kPzvZdZzdC95fv86jgxR7Y4u3QZxt9KP-0lXqpeGXtjoUywc8_1zbfG6mYEuby5lutPqkPX19_NCv2C8ViqZ4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>225207649</pqid></control><display><type>article</type><title>Menstrual cycle-specific inhibition of endometrial stromal cell proliferation by oncostatin M</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Ohata, Yorie ; Harada, Tasuku ; Fujii, Akiko ; Yoshida, Souichi ; Iwabe, Tomio ; Terakawa, Naoki</creator><creatorcontrib>Ohata, Yorie ; Harada, Tasuku ; Fujii, Akiko ; Yoshida, Souichi ; Iwabe, Tomio ; Terakawa, Naoki</creatorcontrib><description>We have investigated the possible roles of oncostatin M (OSM), which is a member of the interleukin-6 family of cytokines, in endometrial and endometriotic stromal cell growth. Endometrial and endometriotic stromal cells were collected from the uterus or ovarian chocolate cysts. We observed the expression of mRNA transcripts for OSM, OSM receptor subunit β, leukaemia inhibitory factor receptor subunit (LIFR), and glycoprotein 130 in endometrial and endometriotic stromal cells. We also examined the effects of OSM (0–50 ng/ml) and LIF (0–10 ng/ml) on endometrial and endometriotic stromal cell proliferation and evaluated the effects of OSM on endometrial stromal cell differentiation. The presence of 10–50 ng/ml OSM significantly suppressed endometrial stromal cell growth in secretory phase tissue but not in proliferative phase tissue. In contrast, stromal cells in endometriotic tissues were resistant to the inhibitory effects of OSM. Addition of LIF did not influence the growth of endometrial stromal cells. We also showed that 10 ng/ml OSM stimulated markers of differentiation causing increased prolactin secretion and cyclooxygenase-2 gene expression in endometrial stromal cells from the secretory phase. These results suggest that OSM may play a pivotal role in regulating the growth and differentiation of endometrial cells. Endometriotic cells may behave differently from normal endometrial cells in terms of the inhibitory response to OSM.</description><identifier>ISSN: 1360-9947</identifier><identifier>EISSN: 1460-2407</identifier><identifier>DOI: 10.1093/molehr/7.7.665</identifier><identifier>PMID: 11420390</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Antigens, CD - genetics ; Antigens, CD - metabolism ; Biological and medical sciences ; Cell Differentiation - drug effects ; Cell Division - drug effects ; cell proliferation ; Cells, Cultured ; Cytokine Receptor gp130 ; differentiation ; endometriosis ; endometrium ; Endometrium - cytology ; Endometrium - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Hormone metabolism and regulation ; Humans ; Leukemia Inhibitory Factor Receptor alpha Subunit ; Mammalian female genital system ; Membrane Glycoproteins - genetics ; Membrane Glycoproteins - metabolism ; Menstrual Cycle - physiology ; Oncostatin M ; Peptides - genetics ; Peptides - metabolism ; Peptides - pharmacology ; Receptors, Cytokine - genetics ; Receptors, Cytokine - metabolism ; Receptors, Oncostatin M ; Receptors, OSM-LIF ; Stromal Cells - cytology ; Stromal Cells - metabolism ; Vertebrates: reproduction</subject><ispartof>Molecular human reproduction, 2001-07, Vol.7 (7), p.665-670</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Jul 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-e734506cd74603babbd315d08bb5c56229d9cb72bd542befcde2b0bc98aa56973</citedby><cites>FETCH-LOGICAL-c551t-e734506cd74603babbd315d08bb5c56229d9cb72bd542befcde2b0bc98aa56973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1069874$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11420390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohata, Yorie</creatorcontrib><creatorcontrib>Harada, Tasuku</creatorcontrib><creatorcontrib>Fujii, Akiko</creatorcontrib><creatorcontrib>Yoshida, Souichi</creatorcontrib><creatorcontrib>Iwabe, Tomio</creatorcontrib><creatorcontrib>Terakawa, Naoki</creatorcontrib><title>Menstrual cycle-specific inhibition of endometrial stromal cell proliferation by oncostatin M</title><title>Molecular human reproduction</title><addtitle>Mol. Hum. Reprod</addtitle><description>We have investigated the possible roles of oncostatin M (OSM), which is a member of the interleukin-6 family of cytokines, in endometrial and endometriotic stromal cell growth. Endometrial and endometriotic stromal cells were collected from the uterus or ovarian chocolate cysts. We observed the expression of mRNA transcripts for OSM, OSM receptor subunit β, leukaemia inhibitory factor receptor subunit (LIFR), and glycoprotein 130 in endometrial and endometriotic stromal cells. We also examined the effects of OSM (0–50 ng/ml) and LIF (0–10 ng/ml) on endometrial and endometriotic stromal cell proliferation and evaluated the effects of OSM on endometrial stromal cell differentiation. The presence of 10–50 ng/ml OSM significantly suppressed endometrial stromal cell growth in secretory phase tissue but not in proliferative phase tissue. In contrast, stromal cells in endometriotic tissues were resistant to the inhibitory effects of OSM. Addition of LIF did not influence the growth of endometrial stromal cells. We also showed that 10 ng/ml OSM stimulated markers of differentiation causing increased prolactin secretion and cyclooxygenase-2 gene expression in endometrial stromal cells from the secretory phase. These results suggest that OSM may play a pivotal role in regulating the growth and differentiation of endometrial cells. Endometriotic cells may behave differently from normal endometrial cells in terms of the inhibitory response to OSM.</description><subject>Antigens, CD - genetics</subject><subject>Antigens, CD - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Division - drug effects</subject><subject>cell proliferation</subject><subject>Cells, Cultured</subject><subject>Cytokine Receptor gp130</subject><subject>differentiation</subject><subject>endometriosis</subject><subject>endometrium</subject><subject>Endometrium - cytology</subject><subject>Endometrium - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormone metabolism and regulation</subject><subject>Humans</subject><subject>Leukemia Inhibitory Factor Receptor alpha Subunit</subject><subject>Mammalian female genital system</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Menstrual Cycle - physiology</subject><subject>Oncostatin M</subject><subject>Peptides - genetics</subject><subject>Peptides - metabolism</subject><subject>Peptides - pharmacology</subject><subject>Receptors, Cytokine - genetics</subject><subject>Receptors, Cytokine - metabolism</subject><subject>Receptors, Oncostatin M</subject><subject>Receptors, OSM-LIF</subject><subject>Stromal Cells - cytology</subject><subject>Stromal Cells - metabolism</subject><subject>Vertebrates: reproduction</subject><issn>1360-9947</issn><issn>1460-2407</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c9rFDEUB_BQlLbWXj2WQcTbbPM7m6MWtUqXiqgUQUKSeUPTziRrMgPuf2_WXVR6kRzyQj55vPBF6BnBC4I1Ox_TALf5XC3UQkpxgI4Jl7ilHKtHtWa11pqrI_SklDuMiaJieYiOCOEUM42P0fcVxDLl2Q6N3_gB2rIGH_rgmxBvgwtTSLFJfQOxSyNMOVRYfRq3D2AYmnVOQ-gh29_SbZoUfSpTPcZm9RQ97u1Q4HS_n6Avb998vrhsr67fvb94ddV6IcjUgmJcYOk7VYdnzjrXMSI6vHROeCEp1Z32TlHXCU4d9L4D6rDzemmtkFqxE_Ry17dO82OGMpkxlO14NkKai1FYCyEZ_S-kmHNGNa7w-QN4l-Yc6ycMpYJiJbmuaLFDPqdSMvRmncNo88YQbLbxmF08RtVV46kPzvZdZzdC95fv86jgxR7Y4u3QZxt9KP-0lXqpeGXtjoUywc8_1zbfG6mYEuby5lutPqkPX19_NCv2C8ViqZ4</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>Ohata, Yorie</creator><creator>Harada, Tasuku</creator><creator>Fujii, Akiko</creator><creator>Yoshida, Souichi</creator><creator>Iwabe, Tomio</creator><creator>Terakawa, Naoki</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20010701</creationdate><title>Menstrual cycle-specific inhibition of endometrial stromal cell proliferation by oncostatin M</title><author>Ohata, Yorie ; Harada, Tasuku ; Fujii, Akiko ; Yoshida, Souichi ; Iwabe, Tomio ; Terakawa, Naoki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-e734506cd74603babbd315d08bb5c56229d9cb72bd542befcde2b0bc98aa56973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Antigens, CD - genetics</topic><topic>Antigens, CD - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Division - drug effects</topic><topic>cell proliferation</topic><topic>Cells, Cultured</topic><topic>Cytokine Receptor gp130</topic><topic>differentiation</topic><topic>endometriosis</topic><topic>endometrium</topic><topic>Endometrium - cytology</topic><topic>Endometrium - metabolism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormone metabolism and regulation</topic><topic>Humans</topic><topic>Leukemia Inhibitory Factor Receptor alpha Subunit</topic><topic>Mammalian female genital system</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Menstrual Cycle - physiology</topic><topic>Oncostatin M</topic><topic>Peptides - genetics</topic><topic>Peptides - metabolism</topic><topic>Peptides - pharmacology</topic><topic>Receptors, Cytokine - genetics</topic><topic>Receptors, Cytokine - metabolism</topic><topic>Receptors, Oncostatin M</topic><topic>Receptors, OSM-LIF</topic><topic>Stromal Cells - cytology</topic><topic>Stromal Cells - metabolism</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohata, Yorie</creatorcontrib><creatorcontrib>Harada, Tasuku</creatorcontrib><creatorcontrib>Fujii, Akiko</creatorcontrib><creatorcontrib>Yoshida, Souichi</creatorcontrib><creatorcontrib>Iwabe, Tomio</creatorcontrib><creatorcontrib>Terakawa, Naoki</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular human reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohata, Yorie</au><au>Harada, Tasuku</au><au>Fujii, Akiko</au><au>Yoshida, Souichi</au><au>Iwabe, Tomio</au><au>Terakawa, Naoki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Menstrual cycle-specific inhibition of endometrial stromal cell proliferation by oncostatin M</atitle><jtitle>Molecular human reproduction</jtitle><addtitle>Mol. Hum. Reprod</addtitle><date>2001-07-01</date><risdate>2001</risdate><volume>7</volume><issue>7</issue><spage>665</spage><epage>670</epage><pages>665-670</pages><issn>1360-9947</issn><eissn>1460-2407</eissn><abstract>We have investigated the possible roles of oncostatin M (OSM), which is a member of the interleukin-6 family of cytokines, in endometrial and endometriotic stromal cell growth. Endometrial and endometriotic stromal cells were collected from the uterus or ovarian chocolate cysts. We observed the expression of mRNA transcripts for OSM, OSM receptor subunit β, leukaemia inhibitory factor receptor subunit (LIFR), and glycoprotein 130 in endometrial and endometriotic stromal cells. We also examined the effects of OSM (0–50 ng/ml) and LIF (0–10 ng/ml) on endometrial and endometriotic stromal cell proliferation and evaluated the effects of OSM on endometrial stromal cell differentiation. The presence of 10–50 ng/ml OSM significantly suppressed endometrial stromal cell growth in secretory phase tissue but not in proliferative phase tissue. In contrast, stromal cells in endometriotic tissues were resistant to the inhibitory effects of OSM. Addition of LIF did not influence the growth of endometrial stromal cells. We also showed that 10 ng/ml OSM stimulated markers of differentiation causing increased prolactin secretion and cyclooxygenase-2 gene expression in endometrial stromal cells from the secretory phase. These results suggest that OSM may play a pivotal role in regulating the growth and differentiation of endometrial cells. Endometriotic cells may behave differently from normal endometrial cells in terms of the inhibitory response to OSM.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>11420390</pmid><doi>10.1093/molehr/7.7.665</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1360-9947 |
| ispartof | Molecular human reproduction, 2001-07, Vol.7 (7), p.665-670 |
| issn | 1360-9947 1460-2407 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70955632 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Antigens, CD - genetics Antigens, CD - metabolism Biological and medical sciences Cell Differentiation - drug effects Cell Division - drug effects cell proliferation Cells, Cultured Cytokine Receptor gp130 differentiation endometriosis endometrium Endometrium - cytology Endometrium - metabolism Female Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Humans Leukemia Inhibitory Factor Receptor alpha Subunit Mammalian female genital system Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Menstrual Cycle - physiology Oncostatin M Peptides - genetics Peptides - metabolism Peptides - pharmacology Receptors, Cytokine - genetics Receptors, Cytokine - metabolism Receptors, Oncostatin M Receptors, OSM-LIF Stromal Cells - cytology Stromal Cells - metabolism Vertebrates: reproduction |
| title | Menstrual cycle-specific inhibition of endometrial stromal cell proliferation by oncostatin M |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T17%3A17%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Menstrual%20cycle-specific%20inhibition%20of%20endometrial%20stromal%20cell%20proliferation%20by%20oncostatin%20M&rft.jtitle=Molecular%20human%20reproduction&rft.au=Ohata,%20Yorie&rft.date=2001-07-01&rft.volume=7&rft.issue=7&rft.spage=665&rft.epage=670&rft.pages=665-670&rft.issn=1360-9947&rft.eissn=1460-2407&rft_id=info:doi/10.1093/molehr/7.7.665&rft_dat=%3Cproquest_cross%3E374211281%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=225207649&rft_id=info:pmid/11420390&rfr_iscdi=true |