The Fc Receptor for IgG (FcγRII; CD32) on human neonatal B lymphocytes

B cells express an Fc receptor for IgG (FcγRII; CD32) which is involved in feedback inhibition of antibody production. Engagement of FcγRII during ligation of the antigen receptor provides an inhibitory signal. FcγRII exists as several isoforms, with FcγRIIb (which carries an immunoreceptor tyrosine...

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Veröffentlicht in:	Human immunology 2001-07, Vol.62 (7), p.679-685
Hauptverfasser:	Jessup, Claire F, Ridings, Jodie, Ho, Alice, Nobbs, Silvia, Roberton, Donal M, Macardle, Peter, Zola, Heddy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AFc receptors Antibodies, Anti-Idiotypic - physiology Antibodies, Monoclonal - physiology B lymphocytes B-Lymphocyte Subsets - cytology B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - metabolism CD32 CD32 antigen cord blood FcγRII Fetal Blood - immunology Fetal Blood - metabolism Growth Inhibitors - physiology Humans Immunoglobulin Fab Fragments - physiology Immunoglobulin M - immunology Immunosuppressive Agents - pharmacology Infant, Newborn Lymphocyte Activation - immunology Protein Isoforms - biosynthesis Protein Isoforms - genetics Receptors, IgG - biosynthesis Receptors, IgG - genetics Reverse Transcriptase Polymerase Chain Reaction
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