PET-Determination of robalzotan (NAD-299) induced 5-HT(1A) receptor occupancy in the monkey brain

The serotonin 5-hydroxytryptamine-1A (5-HT(1A)) receptor subtype is of central interest in research, particularly in the area of pathophysiology and pharmacological treatment of psychiatric disorders. Robalzotan (generic name for NAD-299) is a new putative drug that binds with high selectivity and a...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2000-04, Vol.22 (4), p.422-429
Hauptverfasser:	Farde, L, Andrée, B, Ginovart, N, Halldin, C, Thorberg, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzopyrans - metabolism Brain - diagnostic imaging Brain - drug effects Brain - metabolism Kinetics Macaca Radioligand Assay Receptors, Serotonin - drug effects Receptors, Serotonin - metabolism Receptors, Serotonin, 5-HT1 Serotonin Antagonists - metabolism Tomography, Emission-Computed
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