Evolutionary Divergence of the Mouse and Human Lgn1/SMA Repeat Structures

The orthologous genomic segments on mouse chromosome 13D1–D3 and human chromosome 5q11.2–q13.3 have been extensively studied because of their involvement in two distinct disease phenotypes, spinal muscular atrophy (SMA) in human and susceptibility to Legionella pneumophila (determined by Lgn1) in mi...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 2000-02, Vol.64 (1), p.62-81
Hauptverfasser:	Growney, Joseph D., Scharf, Jeremiah M., Kunkel, Louis M., Dietrich, William F.
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions Animals Biological and medical sciences Blotting, Southern Cell Line chromosome 13 chromosome 5 Chromosome Mapping Classical genetics, quantitative genetics, hybrids Cyclic AMP Response Element-Binding Protein Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Evolution, Molecular Exons Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Humans Legionella pneumophila Legionnaires' Disease - genetics Lgn1 gene Medical sciences Mice Molecular Sequence Data Muscular Atrophy, Spinal - genetics Nerve Tissue Proteins - classification Nerve Tissue Proteins - genetics Neurology Neuronal Apoptosis-Inhibitory Protein Physical Chromosome Mapping Repetitive Sequences, Nucleic Acid RNA-Binding Proteins SMN Complex Proteins spinal muscular atrophy Vertebrata
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