Detailed Comparative Gene Map of Rat Chromosome 1 with Mouse and Human Genomes and Physical Mapping of an Evolutionary Chromosomal Breakpoint
We report the localization of 92 new gene-based markers assigned to rat chromosome 1 by linkage or radiation hybrid mapping. The markers were chosen to enrich gene mapping data in a region of the rat chromosome known to contain several of the principal quantitative trait loci in rodent models of hum...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 2000-02, Vol.64 (1), p.32-43 |
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| creator | Kaisaki, Pamela J. Rouard, Mathias Danoy, Patrick A.C. Wallis, Robert H. Collins, Stephan C. Rice, Michael Levy, Elaine R. Lathrop, Mark Bihoreau, Marie-Thérèse Gauguier, Dominique |
| description | We report the localization of 92 new gene-based markers assigned to rat chromosome 1 by linkage or radiation hybrid mapping. The markers were chosen to enrich gene mapping data in a region of the rat chromosome known to contain several of the principal quantitative trait loci in rodent models of human multifactorial disease. The composite map reported here provides map information on a total of 139 known genes, including 80 that have been localized in mouse and 109 that have been localized in human, and integrates the gene-based markers with anonymous microsatellites. The evolutionary breakpoints identifying 16 segments that are homologous regions in the human genome are defined. These data will facilitate genetic and comparative mapping studies and identification of novel candidate genes for the quantitative trait loci that have been localized to the region. |
| doi_str_mv | 10.1006/geno.1999.6107 |
| format | Article |
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The markers were chosen to enrich gene mapping data in a region of the rat chromosome known to contain several of the principal quantitative trait loci in rodent models of human multifactorial disease. The composite map reported here provides map information on a total of 139 known genes, including 80 that have been localized in mouse and 109 that have been localized in human, and integrates the gene-based markers with anonymous microsatellites. The evolutionary breakpoints identifying 16 segments that are homologous regions in the human genome are defined. These data will facilitate genetic and comparative mapping studies and identification of novel candidate genes for the quantitative trait loci that have been localized to the region.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1006/geno.1999.6107</identifier><identifier>PMID: 10708516</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; chromosome 1 ; Chromosome Mapping ; Classical genetics, quantitative genetics, hybrids ; Evolution, Molecular ; Fundamental and applied biological sciences. Psychology ; Genetics of eukaryotes. Biological and molecular evolution ; Genome, Human ; Humans ; Mice - genetics ; Microsatellite Repeats ; Molecular Sequence Data ; Physical Chromosome Mapping ; Rats - genetics ; Rats, Inbred BN ; Rats, Inbred WKY ; Vertebrata</subject><ispartof>Genomics (San Diego, Calif.), 2000-02, Vol.64 (1), p.32-43</ispartof><rights>2000 Academic Press</rights><rights>2000 INIST-CNRS</rights><rights>Copyright 2000 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-8819c1a59bce61aa99a9ff19452a4a5fee7677a150903067bff15f9d1f3d04603</citedby><cites>FETCH-LOGICAL-c400t-8819c1a59bce61aa99a9ff19452a4a5fee7677a150903067bff15f9d1f3d04603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0888754399961074$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1328448$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10708516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaisaki, Pamela J.</creatorcontrib><creatorcontrib>Rouard, Mathias</creatorcontrib><creatorcontrib>Danoy, Patrick A.C.</creatorcontrib><creatorcontrib>Wallis, Robert H.</creatorcontrib><creatorcontrib>Collins, Stephan C.</creatorcontrib><creatorcontrib>Rice, Michael</creatorcontrib><creatorcontrib>Levy, Elaine R.</creatorcontrib><creatorcontrib>Lathrop, Mark</creatorcontrib><creatorcontrib>Bihoreau, Marie-Thérèse</creatorcontrib><creatorcontrib>Gauguier, Dominique</creatorcontrib><title>Detailed Comparative Gene Map of Rat Chromosome 1 with Mouse and Human Genomes and Physical Mapping of an Evolutionary Chromosomal Breakpoint</title><title>Genomics (San Diego, Calif.)</title><addtitle>Genomics</addtitle><description>We report the localization of 92 new gene-based markers assigned to rat chromosome 1 by linkage or radiation hybrid mapping. The markers were chosen to enrich gene mapping data in a region of the rat chromosome known to contain several of the principal quantitative trait loci in rodent models of human multifactorial disease. The composite map reported here provides map information on a total of 139 known genes, including 80 that have been localized in mouse and 109 that have been localized in human, and integrates the gene-based markers with anonymous microsatellites. The evolutionary breakpoints identifying 16 segments that are homologous regions in the human genome are defined. These data will facilitate genetic and comparative mapping studies and identification of novel candidate genes for the quantitative trait loci that have been localized to the region.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>chromosome 1</subject><subject>Chromosome Mapping</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Evolution, Molecular</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genome, Human</subject><subject>Humans</subject><subject>Mice - genetics</subject><subject>Microsatellite Repeats</subject><subject>Molecular Sequence Data</subject><subject>Physical Chromosome Mapping</subject><subject>Rats - genetics</subject><subject>Rats, Inbred BN</subject><subject>Rats, Inbred WKY</subject><subject>Vertebrata</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi0EokvhyhH5gLhlsRPHsY-wlBapVRGCszXrTLqGxA52slUfou-Mw65ULqgnS55vPs3MT8hrztacMfn-Bn1Yc631WnLWPCErzpQulBTyKVkxpVTR1KI6IS9S-skY05Uqn5OTjDJVc7ki959wAtdjSzdhGCHC5PZIz9EjvYKRho5-g4ludjEMIYUBKae3btrRqzAnpOBbejEP4JeOXE1_f77u7pKz0C-G0fmbxZKRs33o58kFD_HuwZixjxHh1xicn16SZx30CV8d31Py4_PZ981FcXl9_mXz4bKwgrGpUIpry6HWW4uSA2gNuuu4FnUJAuoOsZFNA7xmmlVMNttcrDvd8q5qmZCsOiXvDt4xht8zpskMLlnse_CYFzMN03UpuXoU5E1dClEuxvUBtDGkFLEzY3RD3tRwZpakzJKUWZIyS1K54c3RPG8HbP_BD9Fk4O0RgJSP2UXw1qUHriqVEMuE6oBhvtfeYTTJOvQWWxfRTqYN7n8j_AHjcbAE</recordid><startdate>20000215</startdate><enddate>20000215</enddate><creator>Kaisaki, Pamela J.</creator><creator>Rouard, Mathias</creator><creator>Danoy, Patrick A.C.</creator><creator>Wallis, Robert H.</creator><creator>Collins, Stephan C.</creator><creator>Rice, Michael</creator><creator>Levy, Elaine R.</creator><creator>Lathrop, Mark</creator><creator>Bihoreau, Marie-Thérèse</creator><creator>Gauguier, Dominique</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20000215</creationdate><title>Detailed Comparative Gene Map of Rat Chromosome 1 with Mouse and Human Genomes and Physical Mapping of an Evolutionary Chromosomal Breakpoint</title><author>Kaisaki, Pamela J. ; Rouard, Mathias ; Danoy, Patrick A.C. ; Wallis, Robert H. ; Collins, Stephan C. ; Rice, Michael ; Levy, Elaine R. ; Lathrop, Mark ; Bihoreau, Marie-Thérèse ; Gauguier, Dominique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-8819c1a59bce61aa99a9ff19452a4a5fee7677a150903067bff15f9d1f3d04603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>chromosome 1</topic><topic>Chromosome Mapping</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Evolution, Molecular</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics of eukaryotes. 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The markers were chosen to enrich gene mapping data in a region of the rat chromosome known to contain several of the principal quantitative trait loci in rodent models of human multifactorial disease. The composite map reported here provides map information on a total of 139 known genes, including 80 that have been localized in mouse and 109 that have been localized in human, and integrates the gene-based markers with anonymous microsatellites. The evolutionary breakpoints identifying 16 segments that are homologous regions in the human genome are defined. These data will facilitate genetic and comparative mapping studies and identification of novel candidate genes for the quantitative trait loci that have been localized to the region.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>10708516</pmid><doi>10.1006/geno.1999.6107</doi><tpages>12</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences chromosome 1 Chromosome Mapping Classical genetics, quantitative genetics, hybrids Evolution, Molecular Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Genome, Human Humans Mice - genetics Microsatellite Repeats Molecular Sequence Data Physical Chromosome Mapping Rats - genetics Rats, Inbred BN Rats, Inbred WKY Vertebrata |
| title | Detailed Comparative Gene Map of Rat Chromosome 1 with Mouse and Human Genomes and Physical Mapping of an Evolutionary Chromosomal Breakpoint |
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