Coordinate Control of Sphingolipid Biosynthesis and Multidrug Resistance in Saccharomyces cerevisiae

Multiple or pleiotropic drug resistance often occurs in the yeast Saccharomyces cerevisiae through genetic activation of the Cys6-Zn(II) transcription factors Pdr1p and Pdr3p. Hyperactive alleles of these proteins cause overproduction of target genes that include drug efflux pumps, which in turn con...

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Veröffentlicht in:	The Journal of biological chemistry 2001-06, Vol.276 (26), p.23674-23680
Hauptverfasser:	Hallstrom, Timothy C., Lambert, Laurence, Schorling, Stefan, Balzi, Elisabetta, Goffeau, André, Moye-Rowley, W. Scott
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA, Fungal - metabolism DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Drug Resistance, Microbial Drug Resistance, Multiple Fungal Proteins - metabolism Fungal Proteins - physiology inositol phosphotransferase IPT1 gene mannosyldiinositol phosphorylceramide Mitochondria - genetics Models, Chemical Pdr1 protein Pdr3 protein Phenotype Phosphotransferases (Alcohol Group Acceptor) - biosynthesis Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - physiology Promoter Regions, Genetic Response Elements RNA, Fungal - biosynthesis Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins sphingolipids Sphingolipids - biosynthesis Trans-Activators - metabolism Trans-Activators - physiology Transcription Factors - metabolism Transcription Factors - physiology Transcriptional Activation
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