Regional and cellular distribution of bleomycin hydrolase mRNA in human brain: comparison between Alzheimer's diseased and control brains
Genetic polymorphism of human bleomycin hydrolase (hBH) has been reported to be associated with the risk of sporadic Alzheimer's disease (AD). The regional and cellular distribution of mRNA encoding hBH in the brain from controls and patients with AD was examined using in situ hybridization. A...
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| Veröffentlicht in: | Neuroscience letters 2000-03, Vol.281 (1), p.37-40 |
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| creator | Malherbe, Pari Faull, Richard L.M Richards, J.Grayson |
| description | Genetic polymorphism of human bleomycin hydrolase (hBH) has been reported to be associated with the risk of sporadic Alzheimer's disease (AD). The regional and cellular distribution of mRNA encoding hBH in the brain from controls and patients with AD was examined using in situ hybridization. A hybridization signal, in the form of clusters of single cells, was observed in the white matter. Our results indicate a predominantly astrocytic expression of hBH in the investigated human brain regions. Although the signal intensity was generally reduced in AD brains, the large variability among controls rendered this trend statistically insignificant. |
| doi_str_mv | 10.1016/S0304-3940(00)00802-8 |
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The regional and cellular distribution of mRNA encoding hBH in the brain from controls and patients with AD was examined using in situ hybridization. A hybridization signal, in the form of clusters of single cells, was observed in the white matter. Our results indicate a predominantly astrocytic expression of hBH in the investigated human brain regions. 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The regional and cellular distribution of mRNA encoding hBH in the brain from controls and patients with AD was examined using in situ hybridization. A hybridization signal, in the form of clusters of single cells, was observed in the white matter. Our results indicate a predominantly astrocytic expression of hBH in the investigated human brain regions. Although the signal intensity was generally reduced in AD brains, the large variability among controls rendered this trend statistically insignificant.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - enzymology</subject><subject>Alzheimer’s disease</subject><subject>Biological and medical sciences</subject><subject>Bleomycin hydrolase</subject><subject>Brain - enzymology</subject><subject>Cysteine Endopeptidases - genetics</subject><subject>Cysteine protease</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>Male</subject><subject>Medical sciences</subject><subject>mRNA</subject><subject>Neurology</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkduK1TAUhoMozjj6CEouxMNFdaVN2sYb2QyeYFAY9TrksOpE2mSbtMr2DXxrU7tR7wYCgazv_9da-Qm5z-AZA9Y-_wgN8KqRHJ4APAXooa76G-SU9V1ddbKrb5LTv8gJuZPzVwAQTPDb5IRB27ecwSn5dYlffAx6pDo4anEcl1En6nyekzfLXGo0DtSMGKeD9YFeHVyKo85Ip8v3O7q-LJMO1CTtwwtq47TXyeciMzj_QAx0N_68Qj9hepxXXyxat3WLYS5emzTfJbcGPWa8d7zPyOfXrz6dv60uPrx5d767qCyv2Vz1Yui1q8FZwbBteMc1r520gwTOueglDI3gvWVDK3ltmkY2BmszmEGI1oBpzsijzXef4rcF86wmn9fFdcC4ZNWB5JJ34lqQdW0jmZAFFBtoU8w54aD2yU86HRQDtYal_oSl1iQUrKeEpfqie3BssJgJ3X-qLZ0CPDwCOls9DkkH6_M_rpbFkRXs5YZh-bbvHpPK1mOw6HxCOysX_TWT_AYgm7IV</recordid><startdate>20000303</startdate><enddate>20000303</enddate><creator>Malherbe, Pari</creator><creator>Faull, Richard L.M</creator><creator>Richards, J.Grayson</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20000303</creationdate><title>Regional and cellular distribution of bleomycin hydrolase mRNA in human brain: comparison between Alzheimer's diseased and control brains</title><author>Malherbe, Pari ; Faull, Richard L.M ; Richards, J.Grayson</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-85f8ad20dc51e63474a42d9cf904445890f3548c1f6942b3393be2bfbf556b0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - enzymology</topic><topic>Alzheimer’s disease</topic><topic>Biological and medical sciences</topic><topic>Bleomycin hydrolase</topic><topic>Brain - enzymology</topic><topic>Cysteine Endopeptidases - genetics</topic><topic>Cysteine protease</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Gene Expression Regulation, Enzymologic</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>Male</topic><topic>Medical sciences</topic><topic>mRNA</topic><topic>Neurology</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malherbe, Pari</creatorcontrib><creatorcontrib>Faull, Richard L.M</creatorcontrib><creatorcontrib>Richards, J.Grayson</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malherbe, Pari</au><au>Faull, Richard L.M</au><au>Richards, J.Grayson</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional and cellular distribution of bleomycin hydrolase mRNA in human brain: comparison between Alzheimer's diseased and control brains</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2000-03-03</date><risdate>2000</risdate><volume>281</volume><issue>1</issue><spage>37</spage><epage>40</epage><pages>37-40</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Genetic polymorphism of human bleomycin hydrolase (hBH) has been reported to be associated with the risk of sporadic Alzheimer's disease (AD). 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| ispartof | Neuroscience letters, 2000-03, Vol.281 (1), p.37-40 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aged Aged, 80 and over Alzheimer Disease - enzymology Alzheimer’s disease Biological and medical sciences Bleomycin hydrolase Brain - enzymology Cysteine Endopeptidases - genetics Cysteine protease Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Gene Expression Regulation, Enzymologic Humans In Situ Hybridization Male Medical sciences mRNA Neurology RNA, Messenger - genetics RNA, Messenger - metabolism |
| title | Regional and cellular distribution of bleomycin hydrolase mRNA in human brain: comparison between Alzheimer's diseased and control brains |
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