HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus
The objective of this study was to determine the HLA class II associations of the anticardiolipin (aCL) and anti-beta2GPI (abeta2GPI) antibodies in a large series of European patients with systemic lupus erythematosus (SLE). A cohort of 577 European SLE patients was enrolled. aCL and abeta2GPI were...
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| Veröffentlicht in: | Lupus 2000, Vol.9 (1), p.47-55 |
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| creator | Galeazzi, M Sebastiani, G D Tincani, A Piette, J C Allegri, F Morozzi, G Bellisai, F Scorza, R Ferrara, G B Carcassi, C Font, J Passiu, G Smolen, J Papasteriades, C Houssiau, F Nebro, A F Ramon Garrido, E D Jedryka-Goral, A Marcolongo, R |
| description | The objective of this study was to determine the HLA class II associations of the anticardiolipin (aCL) and anti-beta2GPI (abeta2GPI) antibodies in a large series of European patients with systemic lupus erythematosus (SLE). A cohort of 577 European SLE patients was enrolled. aCL and abeta2GPI were measured by ELISA methods. Molecular typing of HLA-DRB1, DRB3, DRB4, DRB5, DQA1 and DQB1 loci was performed by the polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) method. aCL of IgG, IgM and IgA isotypes were detected in 22.8%, 14% and 13.9% of patients, respectively. IgG and IgM abeta2GPI were detected in 20% of patients. aCL showed positive association with HLA DRB1*04, DRB1*0402, DRB1*0403, DRB1*07, DRB3*0301, DQA1*0201, DQA1*0301, DQB1*0302, and negative association with DQA1*0501, DRB3*0202. abeta2GPI showed positive association with DRB1*0402, DRB1*0403, DQB1*0302. DRB1*0402 carried the highest relative risk for the presence of both aCL (RR=8. 1) and abeta2GPI (RR=4.6). Our results confirm the already described associations of aCL with HLA DR4 and DR7, but also demonstrate that, among the alleles at the DRB1*04 locus, the *0402 was most represented both in aCL and in abeta2GPI positive patients. In addition, HLA class II associations of abeta2GPI are for the first time extensively examined in a large cohort of European SLE patients. |
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A cohort of 577 European SLE patients was enrolled. aCL and abeta2GPI were measured by ELISA methods. Molecular typing of HLA-DRB1, DRB3, DRB4, DRB5, DQA1 and DQB1 loci was performed by the polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) method. aCL of IgG, IgM and IgA isotypes were detected in 22.8%, 14% and 13.9% of patients, respectively. IgG and IgM abeta2GPI were detected in 20% of patients. aCL showed positive association with HLA DRB1*04, DRB1*0402, DRB1*0403, DRB1*07, DRB3*0301, DQA1*0201, DQA1*0301, DQB1*0302, and negative association with DQA1*0501, DRB3*0202. abeta2GPI showed positive association with DRB1*0402, DRB1*0403, DQB1*0302. DRB1*0402 carried the highest relative risk for the presence of both aCL (RR=8. 1) and abeta2GPI (RR=4.6). Our results confirm the already described associations of aCL with HLA DR4 and DR7, but also demonstrate that, among the alleles at the DRB1*04 locus, the *0402 was most represented both in aCL and in abeta2GPI positive patients. In addition, HLA class II associations of abeta2GPI are for the first time extensively examined in a large cohort of European SLE patients.</description><identifier>ISSN: 0961-2033</identifier><identifier>PMID: 10715100</identifier><language>eng</language><publisher>England</publisher><subject>Adolescent ; Adult ; Aged ; Alleles ; Antibodies, Anticardiolipin - immunology ; beta 2-Glycoprotein I ; DNA - analysis ; DNA Probes - chemistry ; Enzyme-Linked Immunosorbent Assay ; Europe ; Female ; Glycoproteins - immunology ; Histocompatibility Testing ; HLA-DQ Antigens - genetics ; HLA-DR Antigens - genetics ; Humans ; Immunoglobulin Isotypes - immunology ; Lupus Erythematosus, Systemic - genetics ; Lupus Erythematosus, Systemic - immunology ; Male ; Middle Aged ; Polymerase Chain Reaction</subject><ispartof>Lupus, 2000, Vol.9 (1), p.47-55</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,4012</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10715100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Galeazzi, M</creatorcontrib><creatorcontrib>Sebastiani, G D</creatorcontrib><creatorcontrib>Tincani, A</creatorcontrib><creatorcontrib>Piette, J C</creatorcontrib><creatorcontrib>Allegri, F</creatorcontrib><creatorcontrib>Morozzi, G</creatorcontrib><creatorcontrib>Bellisai, F</creatorcontrib><creatorcontrib>Scorza, R</creatorcontrib><creatorcontrib>Ferrara, G B</creatorcontrib><creatorcontrib>Carcassi, C</creatorcontrib><creatorcontrib>Font, J</creatorcontrib><creatorcontrib>Passiu, G</creatorcontrib><creatorcontrib>Smolen, J</creatorcontrib><creatorcontrib>Papasteriades, C</creatorcontrib><creatorcontrib>Houssiau, F</creatorcontrib><creatorcontrib>Nebro, A F</creatorcontrib><creatorcontrib>Ramon Garrido, E D</creatorcontrib><creatorcontrib>Jedryka-Goral, A</creatorcontrib><creatorcontrib>Marcolongo, R</creatorcontrib><title>HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus</title><title>Lupus</title><addtitle>Lupus</addtitle><description>The objective of this study was to determine the HLA class II associations of the anticardiolipin (aCL) and anti-beta2GPI (abeta2GPI) antibodies in a large series of European patients with systemic lupus erythematosus (SLE). A cohort of 577 European SLE patients was enrolled. aCL and abeta2GPI were measured by ELISA methods. Molecular typing of HLA-DRB1, DRB3, DRB4, DRB5, DQA1 and DQB1 loci was performed by the polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) method. aCL of IgG, IgM and IgA isotypes were detected in 22.8%, 14% and 13.9% of patients, respectively. IgG and IgM abeta2GPI were detected in 20% of patients. aCL showed positive association with HLA DRB1*04, DRB1*0402, DRB1*0403, DRB1*07, DRB3*0301, DQA1*0201, DQA1*0301, DQB1*0302, and negative association with DQA1*0501, DRB3*0202. abeta2GPI showed positive association with DRB1*0402, DRB1*0403, DQB1*0302. DRB1*0402 carried the highest relative risk for the presence of both aCL (RR=8. 1) and abeta2GPI (RR=4.6). Our results confirm the already described associations of aCL with HLA DR4 and DR7, but also demonstrate that, among the alleles at the DRB1*04 locus, the *0402 was most represented both in aCL and in abeta2GPI positive patients. In addition, HLA class II associations of abeta2GPI are for the first time extensively examined in a large cohort of European SLE patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Antibodies, Anticardiolipin - immunology</subject><subject>beta 2-Glycoprotein I</subject><subject>DNA - analysis</subject><subject>DNA Probes - chemistry</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Europe</subject><subject>Female</subject><subject>Glycoproteins - immunology</subject><subject>Histocompatibility Testing</subject><subject>HLA-DQ Antigens - genetics</subject><subject>HLA-DR Antigens - genetics</subject><subject>Humans</subject><subject>Immunoglobulin Isotypes - immunology</subject><subject>Lupus Erythematosus, Systemic - genetics</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymerase Chain Reaction</subject><issn>0961-2033</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kLFOwzAQhjOAaCm8AvLEFsmO7SQeq6q0kSrB0D1ynAs1cuLgc4T6KjwtKZTp9P_33TfcTbKkKmdpRjlfJPeIH5RSzlR-lywYLZhklC6T7_1hTYzTiKSqiHYOHCCZozdWR-sHJL4jeojW6NBa7-xohzm3v13aQNTZ7q36TY1v7Xx82ROnwzsQhHBpZsN2Cn4EPZBxtsIQkXzZeCJ4xgi9NcRN44QEwjmeoNfR44QPyW2nHcLjda6S48v2uNmnh9ddtVkf0lEKmsqOGQUqpzxvhJJtJlghszKHvBSZkKxVnaJlw7WmTDYXJqMKStOZvNWFkHyVPP9px-A_J8BY9xYNOKcH8BPWBVVCccln8OkKTk0PbT0G2-twrv-fyX8AG5Rxgw</recordid><startdate>2000</startdate><enddate>2000</enddate><creator>Galeazzi, M</creator><creator>Sebastiani, G D</creator><creator>Tincani, A</creator><creator>Piette, J C</creator><creator>Allegri, F</creator><creator>Morozzi, G</creator><creator>Bellisai, F</creator><creator>Scorza, R</creator><creator>Ferrara, G B</creator><creator>Carcassi, C</creator><creator>Font, J</creator><creator>Passiu, G</creator><creator>Smolen, J</creator><creator>Papasteriades, C</creator><creator>Houssiau, F</creator><creator>Nebro, A F</creator><creator>Ramon Garrido, E D</creator><creator>Jedryka-Goral, A</creator><creator>Marcolongo, R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2000</creationdate><title>HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus</title><author>Galeazzi, M ; Sebastiani, G D ; Tincani, A ; Piette, J C ; Allegri, F ; Morozzi, G ; Bellisai, F ; Scorza, R ; Ferrara, G B ; Carcassi, C ; Font, J ; Passiu, G ; Smolen, J ; Papasteriades, C ; Houssiau, F ; Nebro, A F ; Ramon Garrido, E D ; Jedryka-Goral, A ; Marcolongo, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p540-5f1c9e96036b495d24175286e6842451d9f908b3aa015b6b49209e8cfc6da7453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Antibodies, Anticardiolipin - immunology</topic><topic>beta 2-Glycoprotein I</topic><topic>DNA - analysis</topic><topic>DNA Probes - chemistry</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Europe</topic><topic>Female</topic><topic>Glycoproteins - immunology</topic><topic>Histocompatibility Testing</topic><topic>HLA-DQ Antigens - genetics</topic><topic>HLA-DR Antigens - genetics</topic><topic>Humans</topic><topic>Immunoglobulin Isotypes - immunology</topic><topic>Lupus Erythematosus, Systemic - genetics</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymerase Chain Reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Galeazzi, M</creatorcontrib><creatorcontrib>Sebastiani, G D</creatorcontrib><creatorcontrib>Tincani, A</creatorcontrib><creatorcontrib>Piette, J C</creatorcontrib><creatorcontrib>Allegri, F</creatorcontrib><creatorcontrib>Morozzi, G</creatorcontrib><creatorcontrib>Bellisai, F</creatorcontrib><creatorcontrib>Scorza, R</creatorcontrib><creatorcontrib>Ferrara, G B</creatorcontrib><creatorcontrib>Carcassi, C</creatorcontrib><creatorcontrib>Font, J</creatorcontrib><creatorcontrib>Passiu, G</creatorcontrib><creatorcontrib>Smolen, J</creatorcontrib><creatorcontrib>Papasteriades, C</creatorcontrib><creatorcontrib>Houssiau, F</creatorcontrib><creatorcontrib>Nebro, A F</creatorcontrib><creatorcontrib>Ramon Garrido, E D</creatorcontrib><creatorcontrib>Jedryka-Goral, A</creatorcontrib><creatorcontrib>Marcolongo, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Galeazzi, M</au><au>Sebastiani, G D</au><au>Tincani, A</au><au>Piette, J C</au><au>Allegri, F</au><au>Morozzi, G</au><au>Bellisai, F</au><au>Scorza, R</au><au>Ferrara, G B</au><au>Carcassi, C</au><au>Font, J</au><au>Passiu, G</au><au>Smolen, J</au><au>Papasteriades, C</au><au>Houssiau, F</au><au>Nebro, A F</au><au>Ramon Garrido, E D</au><au>Jedryka-Goral, A</au><au>Marcolongo, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2000</date><risdate>2000</risdate><volume>9</volume><issue>1</issue><spage>47</spage><epage>55</epage><pages>47-55</pages><issn>0961-2033</issn><abstract>The objective of this study was to determine the HLA class II associations of the anticardiolipin (aCL) and anti-beta2GPI (abeta2GPI) antibodies in a large series of European patients with systemic lupus erythematosus (SLE). A cohort of 577 European SLE patients was enrolled. aCL and abeta2GPI were measured by ELISA methods. Molecular typing of HLA-DRB1, DRB3, DRB4, DRB5, DQA1 and DQB1 loci was performed by the polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) method. aCL of IgG, IgM and IgA isotypes were detected in 22.8%, 14% and 13.9% of patients, respectively. IgG and IgM abeta2GPI were detected in 20% of patients. aCL showed positive association with HLA DRB1*04, DRB1*0402, DRB1*0403, DRB1*07, DRB3*0301, DQA1*0201, DQA1*0301, DQB1*0302, and negative association with DQA1*0501, DRB3*0202. abeta2GPI showed positive association with DRB1*0402, DRB1*0403, DQB1*0302. DRB1*0402 carried the highest relative risk for the presence of both aCL (RR=8. 1) and abeta2GPI (RR=4.6). Our results confirm the already described associations of aCL with HLA DR4 and DR7, but also demonstrate that, among the alleles at the DRB1*04 locus, the *0402 was most represented both in aCL and in abeta2GPI positive patients. In addition, HLA class II associations of abeta2GPI are for the first time extensively examined in a large cohort of European SLE patients.</abstract><cop>England</cop><pmid>10715100</pmid><tpages>9</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Alleles Antibodies, Anticardiolipin - immunology beta 2-Glycoprotein I DNA - analysis DNA Probes - chemistry Enzyme-Linked Immunosorbent Assay Europe Female Glycoproteins - immunology Histocompatibility Testing HLA-DQ Antigens - genetics HLA-DR Antigens - genetics Humans Immunoglobulin Isotypes - immunology Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Male Middle Aged Polymerase Chain Reaction |
| title | HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus |
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