Gene promoter hypermethylation in tumors and serum of head and neck cancer patients

Promoter hypermethylation is an important pathway for repression of gene transcription in cancer cells. We analyzed aberrant DNA methylation at four genes in primary tumors from 95 head and neck cancer patients and then used the presence of this methylation as a marker for cancer cell detection in s...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-02, Vol.60 (4), p.892-895
Hauptverfasser:	SANCHEZ-CESPEDES, M, ESTELLER, M, LI WU, NAWROZ-DANISH, H, YOO, G. H, KOCH, W. M, JEN, J, HERMAN, J. G, SIDRANSKY, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Regulatory Proteins Biological and medical sciences Calcium-Calmodulin-Dependent Protein Kinases - genetics Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - genetics CDKN2A gene death-associated protein kinase Death-Associated Protein Kinases DNA Methylation Genes, p16 glutathione transferase Head and Neck Neoplasms - blood Head and Neck Neoplasms - genetics Humans Medical sciences O-Methylguanine-DNA Methyltransferase - genetics O@u6-methylguanine-DNA methyltransferase Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Promoter Regions, Genetic Tumors
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