Efficacy and tolerability of topical 1% cidofovir cream for the treatment of external anogenital warts in HIV-infected persons
Treatment options for anogenital warts in patients with HIV-1 are unsatisfactory because they fail to eradicate latent human papillomavirus. To determine tolerability and efficacy of topical 1% cidofovir cream for the treatment of external anogenital warts in HIV-infected patients. A randomized, pla...
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| Veröffentlicht in: | Sexually transmitted diseases 2001-06, Vol.28 (6), p.343-346 |
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| creator | MATTEELLI, Alberto BELTRAME, Anna GRAIFEMBERGHI, Severo FORLEO, Maria Antonietta GULLETTA, Maurizio CIRAVOLO, Giuseppe TEDOLDI, Simona CASALINI, Catia CAROSI, Giampiero |
| description | Treatment options for anogenital warts in patients with HIV-1 are unsatisfactory because they fail to eradicate latent human papillomavirus.
To determine tolerability and efficacy of topical 1% cidofovir cream for the treatment of external anogenital warts in HIV-infected patients.
A randomized, placebo-controlled, single-blind, crossover pilot study of either 1% cidofovir cream or placebo applied once daily 5 days a week for 2 weeks followed by 2 weeks of observation was performed.
Six patients were randomized to 1% cidofovir cream and six to placebo. The latter patients eventually received 1% cidofovir cream. Thus, 12 treatment rounds of cidofovir were compared with six rounds of placebo. A reduction of more than 50% in the total wart area achieved by seven cidofovir treatments (58%), as compared with no placebo regimen (P = 0.02). Local reactions occurred in 10 of the 12 patients treated with cidofovir, as compared with 0 of the 6 subjects in the placebo group (P < 0.001).
For the initial clearance of anogenital warts in HIV-infected patients, 1% cidofovir cream is significantly more effective than vehicle cream. Local mucosal erosion is a common side effect. |
| doi_str_mv | 10.1097/00007435-200106000-00007 |
| format | Article |
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To determine tolerability and efficacy of topical 1% cidofovir cream for the treatment of external anogenital warts in HIV-infected patients.
A randomized, placebo-controlled, single-blind, crossover pilot study of either 1% cidofovir cream or placebo applied once daily 5 days a week for 2 weeks followed by 2 weeks of observation was performed.
Six patients were randomized to 1% cidofovir cream and six to placebo. The latter patients eventually received 1% cidofovir cream. Thus, 12 treatment rounds of cidofovir were compared with six rounds of placebo. A reduction of more than 50% in the total wart area achieved by seven cidofovir treatments (58%), as compared with no placebo regimen (P = 0.02). Local reactions occurred in 10 of the 12 patients treated with cidofovir, as compared with 0 of the 6 subjects in the placebo group (P < 0.001).
For the initial clearance of anogenital warts in HIV-infected patients, 1% cidofovir cream is significantly more effective than vehicle cream. Local mucosal erosion is a common side effect.</description><identifier>ISSN: 0148-5717</identifier><identifier>EISSN: 1537-4521</identifier><identifier>DOI: 10.1097/00007435-200106000-00007</identifier><identifier>PMID: 11403192</identifier><identifier>CODEN: STRDDM</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Administration, Cutaneous ; Adult ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Antiviral Agents - administration & dosage ; Antiviral Agents - therapeutic use ; Anus Diseases - complications ; Anus Diseases - drug therapy ; Biological and medical sciences ; Cidofovir ; Cytosine - administration & dosage ; Cytosine - analogs & derivatives ; Cytosine - therapeutic use ; Female ; Female Urogenital Diseases - complications ; Female Urogenital Diseases - drug therapy ; HIV Infections - complications ; Humans ; Male ; Male Urogenital Diseases ; Medical sciences ; Organophosphonates ; Organophosphorus Compounds - administration & dosage ; Organophosphorus Compounds - therapeutic use ; Patient Satisfaction ; Pharmacology. Drug treatments ; Pilot Projects ; Single-Blind Method ; Treatment Outcome ; Tumor Virus Infections - complications ; Tumor Virus Infections - drug therapy ; Warts - complications ; Warts - drug therapy</subject><ispartof>Sexually transmitted diseases, 2001-06, Vol.28 (6), p.343-346</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-ee3a3c16c0eb6db142e2ff439e0e545ea700e44919aa7e0e28a7f168c5aa22863</citedby><cites>FETCH-LOGICAL-c391t-ee3a3c16c0eb6db142e2ff439e0e545ea700e44919aa7e0e28a7f168c5aa22863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13406944$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11403192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MATTEELLI, Alberto</creatorcontrib><creatorcontrib>BELTRAME, Anna</creatorcontrib><creatorcontrib>GRAIFEMBERGHI, Severo</creatorcontrib><creatorcontrib>FORLEO, Maria Antonietta</creatorcontrib><creatorcontrib>GULLETTA, Maurizio</creatorcontrib><creatorcontrib>CIRAVOLO, Giuseppe</creatorcontrib><creatorcontrib>TEDOLDI, Simona</creatorcontrib><creatorcontrib>CASALINI, Catia</creatorcontrib><creatorcontrib>CAROSI, Giampiero</creatorcontrib><title>Efficacy and tolerability of topical 1% cidofovir cream for the treatment of external anogenital warts in HIV-infected persons</title><title>Sexually transmitted diseases</title><addtitle>Sex Transm Dis</addtitle><description>Treatment options for anogenital warts in patients with HIV-1 are unsatisfactory because they fail to eradicate latent human papillomavirus.
To determine tolerability and efficacy of topical 1% cidofovir cream for the treatment of external anogenital warts in HIV-infected patients.
A randomized, placebo-controlled, single-blind, crossover pilot study of either 1% cidofovir cream or placebo applied once daily 5 days a week for 2 weeks followed by 2 weeks of observation was performed.
Six patients were randomized to 1% cidofovir cream and six to placebo. The latter patients eventually received 1% cidofovir cream. Thus, 12 treatment rounds of cidofovir were compared with six rounds of placebo. A reduction of more than 50% in the total wart area achieved by seven cidofovir treatments (58%), as compared with no placebo regimen (P = 0.02). Local reactions occurred in 10 of the 12 patients treated with cidofovir, as compared with 0 of the 6 subjects in the placebo group (P < 0.001).
For the initial clearance of anogenital warts in HIV-infected patients, 1% cidofovir cream is significantly more effective than vehicle cream. Local mucosal erosion is a common side effect.</description><subject>Administration, Cutaneous</subject><subject>Adult</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Antiviral Agents - administration & dosage</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Anus Diseases - complications</subject><subject>Anus Diseases - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Cidofovir</subject><subject>Cytosine - administration & dosage</subject><subject>Cytosine - analogs & derivatives</subject><subject>Cytosine - therapeutic use</subject><subject>Female</subject><subject>Female Urogenital Diseases - complications</subject><subject>Female Urogenital Diseases - drug therapy</subject><subject>HIV Infections - complications</subject><subject>Humans</subject><subject>Male</subject><subject>Male Urogenital Diseases</subject><subject>Medical sciences</subject><subject>Organophosphonates</subject><subject>Organophosphorus Compounds - administration & dosage</subject><subject>Organophosphorus Compounds - therapeutic use</subject><subject>Patient Satisfaction</subject><subject>Pharmacology. Drug treatments</subject><subject>Pilot Projects</subject><subject>Single-Blind Method</subject><subject>Treatment Outcome</subject><subject>Tumor Virus Infections - complications</subject><subject>Tumor Virus Infections - drug therapy</subject><subject>Warts - complications</subject><subject>Warts - drug therapy</subject><issn>0148-5717</issn><issn>1537-4521</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFv1DAQhS1URJfCX6h8aW8BT2zHyRFVLa1UiQtwjWadMRgl9tb2UvbCb6-XXVpfxu_N92zpMcZBfAAxmI-iHqOkblohQHRVNf-sV2wFWppG6RZO2EqA6httwJyytzn_Enst4A07BVBCwtCu2N9r57xFu-MYJl7iTAnXfvZlx6OrelOXM4cLbv0UXfztE7eJcOEuJl5-Ei9VlYVC2fP0p1AKNYAh_qDgS70-YiqZ-8Bv7743PjiyhSa-oZRjyO_Ya4dzpvfHeca-3Vx_vbpt7r98vrv6dN9YOUBpiCRKC50VtO6mNaiWWueUHEiQVprQCEFKDTAgmuq1PRoHXW81Ytv2nTxjl4d3Nyk-bCmXcfHZ0jxjoLjNoxGDMkrrCvYH0KaYcyI3bpJfMO1GEOO--_F_9-Nz9werRs-Pf2zXC00vwWPZFbg4Aphrqy5hsD6_cFKJblBKPgEv4I1o</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>MATTEELLI, Alberto</creator><creator>BELTRAME, Anna</creator><creator>GRAIFEMBERGHI, Severo</creator><creator>FORLEO, Maria Antonietta</creator><creator>GULLETTA, Maurizio</creator><creator>CIRAVOLO, Giuseppe</creator><creator>TEDOLDI, Simona</creator><creator>CASALINI, Catia</creator><creator>CAROSI, Giampiero</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010601</creationdate><title>Efficacy and tolerability of topical 1% cidofovir cream for the treatment of external anogenital warts in HIV-infected persons</title><author>MATTEELLI, Alberto ; BELTRAME, Anna ; GRAIFEMBERGHI, Severo ; FORLEO, Maria Antonietta ; GULLETTA, Maurizio ; CIRAVOLO, Giuseppe ; TEDOLDI, Simona ; CASALINI, Catia ; CAROSI, Giampiero</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-ee3a3c16c0eb6db142e2ff439e0e545ea700e44919aa7e0e28a7f168c5aa22863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Administration, Cutaneous</topic><topic>Adult</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Antiviral Agents - administration & dosage</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Anus Diseases - complications</topic><topic>Anus Diseases - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Cidofovir</topic><topic>Cytosine - administration & dosage</topic><topic>Cytosine - analogs & derivatives</topic><topic>Cytosine - therapeutic use</topic><topic>Female</topic><topic>Female Urogenital Diseases - complications</topic><topic>Female Urogenital Diseases - drug therapy</topic><topic>HIV Infections - complications</topic><topic>Humans</topic><topic>Male</topic><topic>Male Urogenital Diseases</topic><topic>Medical sciences</topic><topic>Organophosphonates</topic><topic>Organophosphorus Compounds - administration & dosage</topic><topic>Organophosphorus Compounds - therapeutic use</topic><topic>Patient Satisfaction</topic><topic>Pharmacology. Drug treatments</topic><topic>Pilot Projects</topic><topic>Single-Blind Method</topic><topic>Treatment Outcome</topic><topic>Tumor Virus Infections - complications</topic><topic>Tumor Virus Infections - drug therapy</topic><topic>Warts - complications</topic><topic>Warts - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MATTEELLI, Alberto</creatorcontrib><creatorcontrib>BELTRAME, Anna</creatorcontrib><creatorcontrib>GRAIFEMBERGHI, Severo</creatorcontrib><creatorcontrib>FORLEO, Maria Antonietta</creatorcontrib><creatorcontrib>GULLETTA, Maurizio</creatorcontrib><creatorcontrib>CIRAVOLO, Giuseppe</creatorcontrib><creatorcontrib>TEDOLDI, Simona</creatorcontrib><creatorcontrib>CASALINI, Catia</creatorcontrib><creatorcontrib>CAROSI, Giampiero</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Sexually transmitted diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MATTEELLI, Alberto</au><au>BELTRAME, Anna</au><au>GRAIFEMBERGHI, Severo</au><au>FORLEO, Maria Antonietta</au><au>GULLETTA, Maurizio</au><au>CIRAVOLO, Giuseppe</au><au>TEDOLDI, Simona</au><au>CASALINI, Catia</au><au>CAROSI, Giampiero</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy and tolerability of topical 1% cidofovir cream for the treatment of external anogenital warts in HIV-infected persons</atitle><jtitle>Sexually transmitted diseases</jtitle><addtitle>Sex Transm Dis</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>28</volume><issue>6</issue><spage>343</spage><epage>346</epage><pages>343-346</pages><issn>0148-5717</issn><eissn>1537-4521</eissn><coden>STRDDM</coden><abstract>Treatment options for anogenital warts in patients with HIV-1 are unsatisfactory because they fail to eradicate latent human papillomavirus.
To determine tolerability and efficacy of topical 1% cidofovir cream for the treatment of external anogenital warts in HIV-infected patients.
A randomized, placebo-controlled, single-blind, crossover pilot study of either 1% cidofovir cream or placebo applied once daily 5 days a week for 2 weeks followed by 2 weeks of observation was performed.
Six patients were randomized to 1% cidofovir cream and six to placebo. The latter patients eventually received 1% cidofovir cream. Thus, 12 treatment rounds of cidofovir were compared with six rounds of placebo. A reduction of more than 50% in the total wart area achieved by seven cidofovir treatments (58%), as compared with no placebo regimen (P = 0.02). Local reactions occurred in 10 of the 12 patients treated with cidofovir, as compared with 0 of the 6 subjects in the placebo group (P < 0.001).
For the initial clearance of anogenital warts in HIV-infected patients, 1% cidofovir cream is significantly more effective than vehicle cream. Local mucosal erosion is a common side effect.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>11403192</pmid><doi>10.1097/00007435-200106000-00007</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0148-5717 |
| ispartof | Sexually transmitted diseases, 2001-06, Vol.28 (6), p.343-346 |
| issn | 0148-5717 1537-4521 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70947455 |
| source | MEDLINE; Journals@Ovid Complete; Jstor Complete Legacy |
| subjects | Administration, Cutaneous Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - administration & dosage Antiviral Agents - therapeutic use Anus Diseases - complications Anus Diseases - drug therapy Biological and medical sciences Cidofovir Cytosine - administration & dosage Cytosine - analogs & derivatives Cytosine - therapeutic use Female Female Urogenital Diseases - complications Female Urogenital Diseases - drug therapy HIV Infections - complications Humans Male Male Urogenital Diseases Medical sciences Organophosphonates Organophosphorus Compounds - administration & dosage Organophosphorus Compounds - therapeutic use Patient Satisfaction Pharmacology. Drug treatments Pilot Projects Single-Blind Method Treatment Outcome Tumor Virus Infections - complications Tumor Virus Infections - drug therapy Warts - complications Warts - drug therapy |
| title | Efficacy and tolerability of topical 1% cidofovir cream for the treatment of external anogenital warts in HIV-infected persons |
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