Dorsal Retinal Pigment Epithelium Differentiates as Neural Retina in the Microphthalmia (mi/mi) Mouse

Microphthalmia, a bHLH-zip transcription factor associated with the onset and maintenance of pigmentation, identifies the retinal pigment epithelial (RPE) compartment during optic vesicle and optic cup development. To determine a role for microphthalmia (mi) during eye development, the effects of an...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2000-03, Vol.41 (3), p.903-908
Hauptverfasser:	Bumsted, Keely M, Barnstable, Colin J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Differentiation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fluorescent Antibody Technique, Indirect Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Leucine Zippers - genetics Malformations of the eye Medical sciences Mice Mice, Mutant Strains Microphthalmia-Associated Transcription Factor Microphthalmos - genetics Microphthalmos - pathology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Ophthalmology Otx Transcription Factors Photoreceptor Cells, Vertebrate - pathology Pigment Epithelium of Eye - embryology Pigment Epithelium of Eye - growth & development Pigment Epithelium of Eye - metabolism Pigment Epithelium of Eye - pathology Retina - embryology Retina - growth & development Retina - metabolism Retina - pathology Retinal Degeneration - pathology Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - genetics Transcription Factors - metabolism
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