EGR-1 enhances tumor growth and modulates the effect of the Wilms' tumor 1 gene products on tumorigenicity

The Wilms' tumor 1 gene (WT1) encodes a transcription factor of the zinc-finger family and is homozygously mutated or deleted in a subset of Wilms' tumors. Through alternative mRNA splicing, the gene is expressed as four main polypeptides that differ by a stretch of 17 amino acids just N-t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2000-02, Vol.19 (6), p.791-800
Hauptverfasser:	SCHARNHORST, V, MENKE, A. L, ATTEMA, J, HANEVELD, J. K, RITECO, N, VAN STEENBRUGGE, G. J, VAN DER EB, A. J, JOCHEMSEN, A. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - physiology Alternative splicing Amino acids Animals Biological and medical sciences Cell Division Cell Line, Transformed Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Viral Cells DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Early Growth Response Protein 1 Ectopic expression EGR-1 protein Female Fundamental and applied biological sciences. Psychology Gene Deletion Genes Genes, Wilms Tumor Growth rate Immediate-Early Proteins Insulin-like growth factors Kidney Kidney Neoplasms - genetics Kidney Neoplasms - pathology Kidneys Mice Mice, Nude Molecular and cellular biology Neoplasm Proteins - genetics Neoplasm Proteins - physiology Neoplasm Transplantation Phenotypes Prostate Proteins Rats RNA Splicing Transcription factors Transcription Factors - genetics Transcription Factors - physiology Tumor suppressor genes Tumorigenicity Tumors Wilms Tumor - genetics Wilms Tumor - pathology Wilms' tumor WT1 gene WT1 Proteins Zinc finger proteins Zinc Fingers - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!