The HB-19 pseudopeptide 5[Kpsi(CH2N)PR]-TASP inhibits attachment of T lymophocyte- and macrophage-tropic HIV to permissive cells

The HB-19 pseudopeptide 5[Kpsi(CH2N)PR]-TASP[psi(CH2N) indicating a reduced peptide bond], which binds the cell surface-expressed nucleolin, is a potent inhibitor of HIV infection. Here, by using primary T lymphocyte cultures and an experimental cell model to monitor HIV entry, we show that HB-19 in...

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Veröffentlicht in:	AIDS research and human retroviruses 2000-02, Vol.16 (3), p.237-249
Hauptverfasser:	Nisole, S, Krust, B, Dam, E, Bianco, A, Seddiki, N, Loaec, S, Callebaut, C, Guichard, G, Muller, S, Briand, J P, Hovanessian, A G
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Cell Membrane - virology Cells, Cultured Chemokine CCL4 Chemokine CCL5 - pharmacology Drug Resistance, Microbial HeLa Cells HIV-1 - drug effects HIV-1 - isolation & purification HIV-1 - physiology HIV-2 - drug effects HIV-2 - physiology Humans Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - virology Macrophage Inflammatory Proteins - pharmacology Macrophages - virology Molecular Structure Peptides Proteins - chemistry Proteins - pharmacology T-Lymphocytes - virology Virion - drug effects Virion - metabolism Zidovudine - pharmacology
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