2-(Oxalylamino)-Benzoic Acid Is a General, Competitive Inhibitor of Protein-tyrosine Phosphatases

Protein-tyrosine phosphatases (PTPs) are critically involved in regulation of signal transduction processes. Members of this class of enzymes are considered attractive therapeutic targets in several disease states, e.g. diabetes, cancer, and inflammation. However, most reported PTP inhibitors have b...

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Veröffentlicht in:	The Journal of biological chemistry 2000-03, Vol.275 (10), p.7101-7108
Hauptverfasser:	Andersen, Henrik Sune, Iversen, Lars Fogh, Jeppesen, Claus Bekker, Branner, Sven, Norris, Kjeld, Rasmussen, Hanne B., Møller, Karin Bach, Møller, Niels Peter Hundahl
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Catalysis Crystallization Enzyme Inhibitors - pharmacology ortho-Aminobenzoates - pharmacology Oxalates - pharmacology Protein Tyrosine Phosphatases - antagonists & inhibitors Protein Tyrosine Phosphatases - chemistry Time Factors X-Ray Diffraction
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