Serum leptin and habitual fatty acid dietary intake in patients with type 1 diabetes mellitus
To study the contribution of a normal intake of nutrients to the variability of serum leptin concentrations in persons with type 1 diabetes mellitus. We studied the relation between serum leptin and nutrient intake in a cross-sectional study. Serum leptin measured by radioimmunoassay, nutritional da...
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| Veröffentlicht in: | European journal of endocrinology 2000-03, Vol.142 (3), p.263-268 |
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| creator | ROJO-MARTINEZ, G SORIGUER, F. J GARCIA-ALMEIDA, J. M GONZALEZ-ROMERO, S TINAHONES, F MORENO, F RUIZ DE ADANA, S GARRIGA, M. J ESTEVA, I GARCIA-ARNES, J GOMEZ-ZUMAQUERO, J. M |
| description | To study the contribution of a normal intake of nutrients to the variability of serum leptin concentrations in persons with type 1 diabetes mellitus.
We studied the relation between serum leptin and nutrient intake in a cross-sectional study.
Serum leptin measured by radioimmunoassay, nutritional data determined by a self-administered 7-day nutritional questionnaire, and the fatty acid composition of the serum phospholipids (measured by thin layer chromatography and gas chromatography) were determined in 60 patients with type 1 diabetes mellitus. Correlation and regression analyses were performed between serum leptin and dietary fatty acids and serum phospholipid fatty acids.
In the prediction models for the concentrations of serum leptin in men with type 1 diabetes mellitus, the dietary fatty acids displaced the anthropometric variables, and were independent of the serum testosterone concentrations. This fact remained when the prediction was made on the basis of indirect markers of the intake, such as the serum phospholipid fatty acids. In the women, the fatty acids from the diet or from the serum phospholipids also partly explained the variation in serum leptin, although not displacing the anthropometric variables.
Our data suggest that, in non-experimental conditions, the concentrations of serum leptin in men with type 1 diabetes mellitus and, to a lesser extent, those in women with diabetes, may be influenced by the composition of the habitual diet, especially the type of dietary fat. |
| doi_str_mv | 10.1530/eje.0.1420263 |
| format | Article |
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We studied the relation between serum leptin and nutrient intake in a cross-sectional study.
Serum leptin measured by radioimmunoassay, nutritional data determined by a self-administered 7-day nutritional questionnaire, and the fatty acid composition of the serum phospholipids (measured by thin layer chromatography and gas chromatography) were determined in 60 patients with type 1 diabetes mellitus. Correlation and regression analyses were performed between serum leptin and dietary fatty acids and serum phospholipid fatty acids.
In the prediction models for the concentrations of serum leptin in men with type 1 diabetes mellitus, the dietary fatty acids displaced the anthropometric variables, and were independent of the serum testosterone concentrations. This fact remained when the prediction was made on the basis of indirect markers of the intake, such as the serum phospholipid fatty acids. In the women, the fatty acids from the diet or from the serum phospholipids also partly explained the variation in serum leptin, although not displacing the anthropometric variables.
Our data suggest that, in non-experimental conditions, the concentrations of serum leptin in men with type 1 diabetes mellitus and, to a lesser extent, those in women with diabetes, may be influenced by the composition of the habitual diet, especially the type of dietary fat.</description><identifier>ISSN: 0804-4643</identifier><identifier>EISSN: 1479-683X</identifier><identifier>DOI: 10.1530/eje.0.1420263</identifier><identifier>PMID: 10700720</identifier><language>eng</language><publisher>Colchester: Portland Press</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1 - blood ; Diabetes. Impaired glucose tolerance ; Dietary Fats - administration & dosage ; Dietary Proteins - administration & dosage ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Energy Intake ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fatty Acids - administration & dosage ; Feeding Behavior ; Female ; Humans ; Leptin - blood ; Male ; Medical sciences ; Phospholipids - blood ; Predictive Value of Tests ; Radioimmunoassay ; Regression Analysis ; Surveys and Questionnaires</subject><ispartof>European journal of endocrinology, 2000-03, Vol.142 (3), p.263-268</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-dc5221668f453de6c458cfb9f68abb4016059cb4d4bddf2028eb384e2ff022a93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1338954$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10700720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROJO-MARTINEZ, G</creatorcontrib><creatorcontrib>SORIGUER, F. J</creatorcontrib><creatorcontrib>GARCIA-ALMEIDA, J. M</creatorcontrib><creatorcontrib>GONZALEZ-ROMERO, S</creatorcontrib><creatorcontrib>TINAHONES, F</creatorcontrib><creatorcontrib>MORENO, F</creatorcontrib><creatorcontrib>RUIZ DE ADANA, S</creatorcontrib><creatorcontrib>GARRIGA, M. J</creatorcontrib><creatorcontrib>ESTEVA, I</creatorcontrib><creatorcontrib>GARCIA-ARNES, J</creatorcontrib><creatorcontrib>GOMEZ-ZUMAQUERO, J. M</creatorcontrib><title>Serum leptin and habitual fatty acid dietary intake in patients with type 1 diabetes mellitus</title><title>European journal of endocrinology</title><addtitle>Eur J Endocrinol</addtitle><description>To study the contribution of a normal intake of nutrients to the variability of serum leptin concentrations in persons with type 1 diabetes mellitus.
We studied the relation between serum leptin and nutrient intake in a cross-sectional study.
Serum leptin measured by radioimmunoassay, nutritional data determined by a self-administered 7-day nutritional questionnaire, and the fatty acid composition of the serum phospholipids (measured by thin layer chromatography and gas chromatography) were determined in 60 patients with type 1 diabetes mellitus. Correlation and regression analyses were performed between serum leptin and dietary fatty acids and serum phospholipid fatty acids.
In the prediction models for the concentrations of serum leptin in men with type 1 diabetes mellitus, the dietary fatty acids displaced the anthropometric variables, and were independent of the serum testosterone concentrations. This fact remained when the prediction was made on the basis of indirect markers of the intake, such as the serum phospholipid fatty acids. In the women, the fatty acids from the diet or from the serum phospholipids also partly explained the variation in serum leptin, although not displacing the anthropometric variables.
Our data suggest that, in non-experimental conditions, the concentrations of serum leptin in men with type 1 diabetes mellitus and, to a lesser extent, those in women with diabetes, may be influenced by the composition of the habitual diet, especially the type of dietary fat.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Proteins - administration & dosage</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Energy Intake</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fatty Acids - administration & dosage</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Humans</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Phospholipids - blood</subject><subject>Predictive Value of Tests</subject><subject>Radioimmunoassay</subject><subject>Regression Analysis</subject><subject>Surveys and Questionnaires</subject><issn>0804-4643</issn><issn>1479-683X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtLxDAYxIMo7rp69Co5iLdq2jyaHmXxBQseVPAiJY8vbNa2W5sU2f_eSBf0NHP4McwMQuc5uc45JTewgetkWUEKQQ_QPGdllQlJ3w_RnEjCMiYYnaGTEDaE5MmTYzTLSUlIWZA5-niBYWxxA330HVadxWulfRxVg52KcYeV8RZbD1ENO-y7qD4hCe5V9NDFgL99XOO46wHnCVMaIgTcQtOkkHCKjpxqApztdYHe7u9el4_Z6vnhaXm7ygyVImbW8KLIhZCOcWpBGMalcbpyQiqtWapNeGU0s0xb69JSCZpKBoVzpChURRfoasrth-3XCCHWrQ8mlVAdbMdQl6RivOQygdkEmmEbwgCu7gffpml1TurfP-v0Z53s9GfiL_bBo27B_qOnAxNwuQdUMKpxg-qMD38cpbLijP4AIuZ-TQ</recordid><startdate>20000301</startdate><enddate>20000301</enddate><creator>ROJO-MARTINEZ, G</creator><creator>SORIGUER, F. 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Target tissue resistance</topic><topic>Fatty Acids - administration & dosage</topic><topic>Feeding Behavior</topic><topic>Female</topic><topic>Humans</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Phospholipids - blood</topic><topic>Predictive Value of Tests</topic><topic>Radioimmunoassay</topic><topic>Regression Analysis</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROJO-MARTINEZ, G</creatorcontrib><creatorcontrib>SORIGUER, F. J</creatorcontrib><creatorcontrib>GARCIA-ALMEIDA, J. M</creatorcontrib><creatorcontrib>GONZALEZ-ROMERO, S</creatorcontrib><creatorcontrib>TINAHONES, F</creatorcontrib><creatorcontrib>MORENO, F</creatorcontrib><creatorcontrib>RUIZ DE ADANA, S</creatorcontrib><creatorcontrib>GARRIGA, M. J</creatorcontrib><creatorcontrib>ESTEVA, I</creatorcontrib><creatorcontrib>GARCIA-ARNES, J</creatorcontrib><creatorcontrib>GOMEZ-ZUMAQUERO, J. M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROJO-MARTINEZ, G</au><au>SORIGUER, F. J</au><au>GARCIA-ALMEIDA, J. M</au><au>GONZALEZ-ROMERO, S</au><au>TINAHONES, F</au><au>MORENO, F</au><au>RUIZ DE ADANA, S</au><au>GARRIGA, M. J</au><au>ESTEVA, I</au><au>GARCIA-ARNES, J</au><au>GOMEZ-ZUMAQUERO, J. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum leptin and habitual fatty acid dietary intake in patients with type 1 diabetes mellitus</atitle><jtitle>European journal of endocrinology</jtitle><addtitle>Eur J Endocrinol</addtitle><date>2000-03-01</date><risdate>2000</risdate><volume>142</volume><issue>3</issue><spage>263</spage><epage>268</epage><pages>263-268</pages><issn>0804-4643</issn><eissn>1479-683X</eissn><abstract>To study the contribution of a normal intake of nutrients to the variability of serum leptin concentrations in persons with type 1 diabetes mellitus.
We studied the relation between serum leptin and nutrient intake in a cross-sectional study.
Serum leptin measured by radioimmunoassay, nutritional data determined by a self-administered 7-day nutritional questionnaire, and the fatty acid composition of the serum phospholipids (measured by thin layer chromatography and gas chromatography) were determined in 60 patients with type 1 diabetes mellitus. Correlation and regression analyses were performed between serum leptin and dietary fatty acids and serum phospholipid fatty acids.
In the prediction models for the concentrations of serum leptin in men with type 1 diabetes mellitus, the dietary fatty acids displaced the anthropometric variables, and were independent of the serum testosterone concentrations. This fact remained when the prediction was made on the basis of indirect markers of the intake, such as the serum phospholipid fatty acids. In the women, the fatty acids from the diet or from the serum phospholipids also partly explained the variation in serum leptin, although not displacing the anthropometric variables.
Our data suggest that, in non-experimental conditions, the concentrations of serum leptin in men with type 1 diabetes mellitus and, to a lesser extent, those in women with diabetes, may be influenced by the composition of the habitual diet, especially the type of dietary fat.</abstract><cop>Colchester</cop><pub>Portland Press</pub><pmid>10700720</pmid><doi>10.1530/eje.0.1420263</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0804-4643 |
| ispartof | European journal of endocrinology, 2000-03, Vol.142 (3), p.263-268 |
| issn | 0804-4643 1479-683X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70945758 |
| source | Oxford University Press Journals; MEDLINE |
| subjects | Adolescent Adult Biological and medical sciences Chromatography, High Pressure Liquid Cross-Sectional Studies Diabetes Mellitus, Type 1 - blood Diabetes. Impaired glucose tolerance Dietary Fats - administration & dosage Dietary Proteins - administration & dosage Endocrine pancreas. Apud cells (diseases) Endocrinopathies Energy Intake Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty Acids - administration & dosage Feeding Behavior Female Humans Leptin - blood Male Medical sciences Phospholipids - blood Predictive Value of Tests Radioimmunoassay Regression Analysis Surveys and Questionnaires |
| title | Serum leptin and habitual fatty acid dietary intake in patients with type 1 diabetes mellitus |
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