CDK Inactivation Is the Only Essential Function of the APC/C and the Mitotic Exit Network Proteins for Origin Resetting during Mitosis
Passage through mitosis is required to reset replication origins for the subsequent S phase. During mitosis, a series of biochemical reactions involving cyclin-dependent kinases (CDKs), the anaphase promoting complex or cyclosome (APC/C), and a mitotic exit network including Cdc5, 14, and 15 coordin...
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| Veröffentlicht in: | Molecular cell 2000, Vol.5 (1), p.85-95 |
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| container_title | Molecular cell |
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| creator | Noton, Elizabeth Diffley, John F.X. |
| description | Passage through mitosis is required to reset replication origins for the subsequent S phase. During mitosis, a series of biochemical reactions involving cyclin-dependent kinases (CDKs), the anaphase promoting complex or cyclosome (APC/C), and a mitotic exit network including Cdc5, 14, and 15 coordinates the proper separation and segregation of sister chromatids. Here we show that cyclin B/CDK inactivation can drive origin resetting in either early S phase or mitosis. This origin resetting occurs efficiently in the absence of APC/C function and mitotic exit network function. We conclude that CDK inactivation is the single essential event in mitosis required to allow pre-RC assembly for the next cell cycle. |
| doi_str_mv | 10.1016/S1097-2765(00)80405-0 |
| format | Article |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Anaphase-Promoting Complex-Cyclosome CDC28 Protein Kinase, S cerevisiae - metabolism Cell Cycle - physiology Cell Cycle Proteins - metabolism Chromatids - physiology Cyclin-Dependent Kinases - metabolism Fungal Proteins - metabolism Genotype GTP-Binding Proteins - metabolism Ligases - physiology Mitosis - physiology Protein Tyrosine Phosphatases RNA-Binding Proteins S Phase Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins Ubiquitin-Protein Ligase Complexes Ubiquitin-Protein Ligases |
| title | CDK Inactivation Is the Only Essential Function of the APC/C and the Mitotic Exit Network Proteins for Origin Resetting during Mitosis |
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