Oxidation and erythrocyte senescence
Direct macrophage recognition of an externalized phosphatidylserine signal on senescent erythrocytes is a process of erythrophagocytic clearance that is in line with the general clearance process of all other circulating cells that become apoptotic. Advances in deciphering this process suggest that...
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| Veröffentlicht in: | Current opinion in hematology 2000-03, Vol.7 (2), p.113-116 |
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| container_title | Current opinion in hematology |
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| creator | Kiefer, Charles R Snyder, L Michael |
| description | Direct macrophage recognition of an externalized phosphatidylserine signal on senescent erythrocytes is a process of erythrophagocytic clearance that is in line with the general clearance process of all other circulating cells that become apoptotic. Advances in deciphering this process suggest that oxidation of the erythrocyte’s hemoglobin, the salient target of the free radicals encountered in the circulatory environment, may drive subsequent steps. The progressive accumulation of oxidized hemoglobin covalently bound to the membrane skeleton not only disrupts membrane organization but also threatens eventual phospholipid oxidation via a calcium-promoted quasi-lipoxygenase activity. The emergence on the cell surface of a threshold concentration of oxidized phospholipids, principally phosphatidylserine, signals recognition by the CD36 macrophage receptor. |
| doi_str_mv | 10.1097/00062752-200003000-00007 |
| format | Article |
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Advances in deciphering this process suggest that oxidation of the erythrocyte’s hemoglobin, the salient target of the free radicals encountered in the circulatory environment, may drive subsequent steps. The progressive accumulation of oxidized hemoglobin covalently bound to the membrane skeleton not only disrupts membrane organization but also threatens eventual phospholipid oxidation via a calcium-promoted quasi-lipoxygenase activity. 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| fulltext | fulltext |
| identifier | ISSN: 1065-6251 |
| ispartof | Current opinion in hematology, 2000-03, Vol.7 (2), p.113-116 |
| issn | 1065-6251 1531-7048 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70945172 |
| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Animals CD36 Antigens - metabolism Erythrocyte Aging - physiology Hemoglobins - metabolism Humans Macrophages - immunology Macrophages - metabolism Oxidation-Reduction Phosphatidylserines - metabolism Signal Transduction |
| title | Oxidation and erythrocyte senescence |
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