Lack of cortical contrast gain control in human photosensitive epilepsy
Television and video games may be powerful triggers for visually induced epileptic seizures. To better understand the triggering elements of visual stimuli and cortical mechanisms of hyperexcitability, we examined eleven patients with idiopathic photosensitive epilepsy by recording visually evoked p...
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| Veröffentlicht in: | Nature neuroscience 2000-03, Vol.3 (3), p.259-263 |
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| creator | Porciatti, Vittorio Bonanni, Paolo Fiorentini, Adriana Guerrini, Renzo |
| description | Television and video games may be powerful triggers for visually induced epileptic seizures. To better understand the triggering elements of visual stimuli and cortical mechanisms of hyperexcitability, we examined eleven patients with idiopathic photosensitive epilepsy by recording visually evoked potentials (VEPs) in response to temporally modulated patterns of different contrast. For stimuli of low–medium, but not high, temporal frequency, the contrast dependence of VEP amplitude and latency is remarkably abnormal for luminance contrast (black–white), but not so for chromatic contrast (equiluminant red–green) stimuli. We conclude that cortical mechanisms of contrast gain control for pattern stimuli of relatively low temporal frequency and high luminance contrast are lacking or severely impaired in photosensitive subjects. |
| doi_str_mv | 10.1038/72972 |
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To better understand the triggering elements of visual stimuli and cortical mechanisms of hyperexcitability, we examined eleven patients with idiopathic photosensitive epilepsy by recording visually evoked potentials (VEPs) in response to temporally modulated patterns of different contrast. For stimuli of low–medium, but not high, temporal frequency, the contrast dependence of VEP amplitude and latency is remarkably abnormal for luminance contrast (black–white), but not so for chromatic contrast (equiluminant red–green) stimuli. 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To better understand the triggering elements of visual stimuli and cortical mechanisms of hyperexcitability, we examined eleven patients with idiopathic photosensitive epilepsy by recording visually evoked potentials (VEPs) in response to temporally modulated patterns of different contrast. For stimuli of low–medium, but not high, temporal frequency, the contrast dependence of VEP amplitude and latency is remarkably abnormal for luminance contrast (black–white), but not so for chromatic contrast (equiluminant red–green) stimuli. 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physiology</topic><topic>Diagnosis</topic><topic>Electroencephalography</topic><topic>Epilepsy</topic><topic>Epilepsy, Reflex - physiopathology</topic><topic>Evoked potentials (Electrophysiology)</topic><topic>Evoked Potentials, Visual - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Light</topic><topic>Male</topic><topic>Neurobiology</topic><topic>Neurosciences</topic><topic>Photic Stimulation</topic><topic>Physiological aspects</topic><topic>Risk factors</topic><topic>Seizures - physiopathology</topic><topic>Time Factors</topic><topic>Visual Cortex - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Porciatti, Vittorio</creatorcontrib><creatorcontrib>Bonanni, Paolo</creatorcontrib><creatorcontrib>Fiorentini, Adriana</creatorcontrib><creatorcontrib>Guerrini, Renzo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Porciatti, Vittorio</au><au>Bonanni, Paolo</au><au>Fiorentini, Adriana</au><au>Guerrini, Renzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of cortical contrast gain control in human photosensitive epilepsy</atitle><jtitle>Nature neuroscience</jtitle><stitle>Nat Neurosci</stitle><addtitle>Nat Neurosci</addtitle><date>2000-03-01</date><risdate>2000</risdate><volume>3</volume><issue>3</issue><spage>259</spage><epage>263</epage><pages>259-263</pages><issn>1097-6256</issn><eissn>1546-1726</eissn><coden>NANEFN</coden><abstract>Television and video games may be powerful triggers for visually induced epileptic seizures. To better understand the triggering elements of visual stimuli and cortical mechanisms of hyperexcitability, we examined eleven patients with idiopathic photosensitive epilepsy by recording visually evoked potentials (VEPs) in response to temporally modulated patterns of different contrast. For stimuli of low–medium, but not high, temporal frequency, the contrast dependence of VEP amplitude and latency is remarkably abnormal for luminance contrast (black–white), but not so for chromatic contrast (equiluminant red–green) stimuli. We conclude that cortical mechanisms of contrast gain control for pattern stimuli of relatively low temporal frequency and high luminance contrast are lacking or severely impaired in photosensitive subjects.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>10700258</pmid><doi>10.1038/72972</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Analysis of Variance Animal Genetics and Genomics Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Cerebral cortex Color Contrast Sensitivity - physiology Diagnosis Electroencephalography Epilepsy Epilepsy, Reflex - physiopathology Evoked potentials (Electrophysiology) Evoked Potentials, Visual - physiology Female Humans Light Male Neurobiology Neurosciences Photic Stimulation Physiological aspects Risk factors Seizures - physiopathology Time Factors Visual Cortex - physiopathology |
| title | Lack of cortical contrast gain control in human photosensitive epilepsy |
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