Efficacy of ultrasound B‐scan compared with physical examination in follow‐up of melanoma patients
BACKGROUND The value of ultrasound B‐scan for routine follow‐up of melanoma patients still is not generally accepted. Therefore, the authors compared the efficacy of physical examination (PE) with ultrasound B‐scan (UBS) for detection of regional tumor recurrence in melanoma patients. The aim of the...
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| Veröffentlicht in: | Cancer 2001-06, Vol.91 (12), p.2409-2416 |
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| creator | Voit, Christiane Mayer, Thomas Kron, Martina Schoengen, Alfred Sterry, Wolfram Weber, Lutz Proebstle, Thomas M. |
| description | BACKGROUND
The value of ultrasound B‐scan for routine follow‐up of melanoma patients still is not generally accepted. Therefore, the authors compared the efficacy of physical examination (PE) with ultrasound B‐scan (UBS) for detection of regional tumor recurrence in melanoma patients. The aim of the current study was to evaluate whether early detection of metastases improves relapse‐free and overall survival.
METHODS
For a period of 4 years, 829 consecutive melanoma patients were followed prospectively. Physical examination of 3011 patients and concomitant UBS of in‐transit routes and regional lymph node basins were performed. Suspicious lesions were diagnosed by fine‐needle aspiration cytology and pathology.
RESULTS
During the study period, 242 (90.6%) of 267 patients with melanoma recurrences were first recognized by PE or UBS within the routine follow‐up program. The sensitivities of both methods differed significantly (P = 0.001). Metastases were detected by PE in only 61 of 242 recurrences (25.2%, 95% confidence interval [CI]: 19.9–31.2%), whereas UBS revealed 240 recurrences (99.2%, 95% CI: 97.3–99.6%). The specificity was 98.4% (95% CI: 97.8–98.8%) and 98.3% (95% CI: 97.7–98.7%), respectively. Survival of 103 patients who presented with a first nodal melanoma recurrence was followed and analyzed by multiple Cox regression. Overall survival was affected by the diameter of the largest metastasis (P = 0.001) and the number of metastatic lesions (P = 0.012).
CONCLUSION
The study found that ultrasound B‐scan was highly effective in the early detection of regional melanoma metastases compared with physical examination. Earlier detection of such metastases seemed to result in improved overall survival. Cancer 2001;91:2409–16. © 2001 American Cancer Society.
Regional tumor recurrences of melanoma were detected earlier with ultrasound B‐scan than with physical examination. Better overall survival was noted in patients who had smaller metastases and a lower number of metastases. |
| doi_str_mv | 10.1002/1097-0142(20010615)91:12<2409::AID-CNCR1275>3.0.CO;2-S |
| format | Article |
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The value of ultrasound B‐scan for routine follow‐up of melanoma patients still is not generally accepted. Therefore, the authors compared the efficacy of physical examination (PE) with ultrasound B‐scan (UBS) for detection of regional tumor recurrence in melanoma patients. The aim of the current study was to evaluate whether early detection of metastases improves relapse‐free and overall survival.
METHODS
For a period of 4 years, 829 consecutive melanoma patients were followed prospectively. Physical examination of 3011 patients and concomitant UBS of in‐transit routes and regional lymph node basins were performed. Suspicious lesions were diagnosed by fine‐needle aspiration cytology and pathology.
RESULTS
During the study period, 242 (90.6%) of 267 patients with melanoma recurrences were first recognized by PE or UBS within the routine follow‐up program. The sensitivities of both methods differed significantly (P = 0.001). Metastases were detected by PE in only 61 of 242 recurrences (25.2%, 95% confidence interval [CI]: 19.9–31.2%), whereas UBS revealed 240 recurrences (99.2%, 95% CI: 97.3–99.6%). The specificity was 98.4% (95% CI: 97.8–98.8%) and 98.3% (95% CI: 97.7–98.7%), respectively. Survival of 103 patients who presented with a first nodal melanoma recurrence was followed and analyzed by multiple Cox regression. Overall survival was affected by the diameter of the largest metastasis (P = 0.001) and the number of metastatic lesions (P = 0.012).
CONCLUSION
The study found that ultrasound B‐scan was highly effective in the early detection of regional melanoma metastases compared with physical examination. Earlier detection of such metastases seemed to result in improved overall survival. Cancer 2001;91:2409–16. © 2001 American Cancer Society.
Regional tumor recurrences of melanoma were detected earlier with ultrasound B‐scan than with physical examination. Better overall survival was noted in patients who had smaller metastases and a lower number of metastases.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(20010615)91:12<2409::AID-CNCR1275>3.0.CO;2-S</identifier><identifier>PMID: 11413532</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Child ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Melanoma - diagnosis ; Melanoma - diagnostic imaging ; Melanoma - mortality ; melanoma follow‐up ; Middle Aged ; Miscellaneous. Technology ; Neoplasm Metastasis - diagnosis ; overall survival ; Physical Examination ; Prognosis ; Sensitivity and Specificity ; Skin Neoplasms - diagnosis ; Skin Neoplasms - diagnostic imaging ; Skin Neoplasms - mortality ; Ultrasonic investigative techniques ; Ultrasonography ; ultrasound B‐scan</subject><ispartof>Cancer, 2001-06, Vol.91 (12), p.2409-2416</ispartof><rights>Copyright © 2001 American Cancer Society</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2001 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4785-ff3e081e8bcf0ef880e0707ad26be6b78d06c3fa8a51af8f6c752dd4ba886d2f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F1097-0142%2820010615%2991%3A12%3C2409%3A%3AAID-CNCR1275%3E3.0.CO%3B2-S$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F1097-0142%2820010615%2991%3A12%3C2409%3A%3AAID-CNCR1275%3E3.0.CO%3B2-S$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1098983$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11413532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Voit, Christiane</creatorcontrib><creatorcontrib>Mayer, Thomas</creatorcontrib><creatorcontrib>Kron, Martina</creatorcontrib><creatorcontrib>Schoengen, Alfred</creatorcontrib><creatorcontrib>Sterry, Wolfram</creatorcontrib><creatorcontrib>Weber, Lutz</creatorcontrib><creatorcontrib>Proebstle, Thomas M.</creatorcontrib><title>Efficacy of ultrasound B‐scan compared with physical examination in follow‐up of melanoma patients</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
The value of ultrasound B‐scan for routine follow‐up of melanoma patients still is not generally accepted. Therefore, the authors compared the efficacy of physical examination (PE) with ultrasound B‐scan (UBS) for detection of regional tumor recurrence in melanoma patients. The aim of the current study was to evaluate whether early detection of metastases improves relapse‐free and overall survival.
METHODS
For a period of 4 years, 829 consecutive melanoma patients were followed prospectively. Physical examination of 3011 patients and concomitant UBS of in‐transit routes and regional lymph node basins were performed. Suspicious lesions were diagnosed by fine‐needle aspiration cytology and pathology.
RESULTS
During the study period, 242 (90.6%) of 267 patients with melanoma recurrences were first recognized by PE or UBS within the routine follow‐up program. The sensitivities of both methods differed significantly (P = 0.001). Metastases were detected by PE in only 61 of 242 recurrences (25.2%, 95% confidence interval [CI]: 19.9–31.2%), whereas UBS revealed 240 recurrences (99.2%, 95% CI: 97.3–99.6%). The specificity was 98.4% (95% CI: 97.8–98.8%) and 98.3% (95% CI: 97.7–98.7%), respectively. Survival of 103 patients who presented with a first nodal melanoma recurrence was followed and analyzed by multiple Cox regression. Overall survival was affected by the diameter of the largest metastasis (P = 0.001) and the number of metastatic lesions (P = 0.012).
CONCLUSION
The study found that ultrasound B‐scan was highly effective in the early detection of regional melanoma metastases compared with physical examination. Earlier detection of such metastases seemed to result in improved overall survival. Cancer 2001;91:2409–16. © 2001 American Cancer Society.
Regional tumor recurrences of melanoma were detected earlier with ultrasound B‐scan than with physical examination. Better overall survival was noted in patients who had smaller metastases and a lower number of metastases.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanoma - diagnosis</subject><subject>Melanoma - diagnostic imaging</subject><subject>Melanoma - mortality</subject><subject>melanoma follow‐up</subject><subject>Middle Aged</subject><subject>Miscellaneous. Technology</subject><subject>Neoplasm Metastasis - diagnosis</subject><subject>overall survival</subject><subject>Physical Examination</subject><subject>Prognosis</subject><subject>Sensitivity and Specificity</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - diagnostic imaging</subject><subject>Skin Neoplasms - mortality</subject><subject>Ultrasonic investigative techniques</subject><subject>Ultrasonography</subject><subject>ultrasound B‐scan</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkdGK1DAUhoMo7rj6CpILEb3oeJK0TTrKwlpXXVgccFUEL0KaJmwkbWrTMs6dj-Az-iRmmNnVGy-8Cid85z8__4_QCYElAaDPCFQ8A5LTJxSAQEmKpxVZEfqC5lCtVqfnr7L6Xf2eUF6csCUs6_Vzml3eQoubxdtoAQAiK3L2-Qjdi_FrGjkt2F10REhOWMHoAtkza51WeouDxbOfRhXD3Lf45a8fP6NWPdahG9RoWrxx0xUerrYx4R6b76pzvZpc6LHrsQ3eh03amYedUGe86kOn8JAI00_xPrpjlY_mweE9Rh9fn32o32YX6zfn9elFpnMuisxaZkAQIxptwVghwAAHrlpaNqZsuGih1MwqoQqirLCl5gVt27xRQpQttewYPd7rDmP4Nps4yc5FbXyyY8IcJYcqZ4yWCfy0B_UYYhyNlcPoOjVuJQG5a0DugpS7IOV1A7IikqQxNSBlakBeNyCZBFmvJZWXSfjhwcHcdKb9I3uIPAGPDoBKAXs7ql67-Nf5SlSCJezLHts4b7b_6e4f5m7-2G91WrFq</recordid><startdate>20010615</startdate><enddate>20010615</enddate><creator>Voit, Christiane</creator><creator>Mayer, Thomas</creator><creator>Kron, Martina</creator><creator>Schoengen, Alfred</creator><creator>Sterry, Wolfram</creator><creator>Weber, Lutz</creator><creator>Proebstle, Thomas M.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010615</creationdate><title>Efficacy of ultrasound B‐scan compared with physical examination in follow‐up of melanoma patients</title><author>Voit, Christiane ; Mayer, Thomas ; Kron, Martina ; Schoengen, Alfred ; Sterry, Wolfram ; Weber, Lutz ; Proebstle, Thomas M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4785-ff3e081e8bcf0ef880e0707ad26be6b78d06c3fa8a51af8f6c752dd4ba886d2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Female</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melanoma - diagnosis</topic><topic>Melanoma - diagnostic imaging</topic><topic>Melanoma - mortality</topic><topic>melanoma follow‐up</topic><topic>Middle Aged</topic><topic>Miscellaneous. Technology</topic><topic>Neoplasm Metastasis - diagnosis</topic><topic>overall survival</topic><topic>Physical Examination</topic><topic>Prognosis</topic><topic>Sensitivity and Specificity</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - diagnostic imaging</topic><topic>Skin Neoplasms - mortality</topic><topic>Ultrasonic investigative techniques</topic><topic>Ultrasonography</topic><topic>ultrasound B‐scan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Voit, Christiane</creatorcontrib><creatorcontrib>Mayer, Thomas</creatorcontrib><creatorcontrib>Kron, Martina</creatorcontrib><creatorcontrib>Schoengen, Alfred</creatorcontrib><creatorcontrib>Sterry, Wolfram</creatorcontrib><creatorcontrib>Weber, Lutz</creatorcontrib><creatorcontrib>Proebstle, Thomas M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Voit, Christiane</au><au>Mayer, Thomas</au><au>Kron, Martina</au><au>Schoengen, Alfred</au><au>Sterry, Wolfram</au><au>Weber, Lutz</au><au>Proebstle, Thomas M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of ultrasound B‐scan compared with physical examination in follow‐up of melanoma patients</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2001-06-15</date><risdate>2001</risdate><volume>91</volume><issue>12</issue><spage>2409</spage><epage>2416</epage><pages>2409-2416</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND
The value of ultrasound B‐scan for routine follow‐up of melanoma patients still is not generally accepted. Therefore, the authors compared the efficacy of physical examination (PE) with ultrasound B‐scan (UBS) for detection of regional tumor recurrence in melanoma patients. The aim of the current study was to evaluate whether early detection of metastases improves relapse‐free and overall survival.
METHODS
For a period of 4 years, 829 consecutive melanoma patients were followed prospectively. Physical examination of 3011 patients and concomitant UBS of in‐transit routes and regional lymph node basins were performed. Suspicious lesions were diagnosed by fine‐needle aspiration cytology and pathology.
RESULTS
During the study period, 242 (90.6%) of 267 patients with melanoma recurrences were first recognized by PE or UBS within the routine follow‐up program. The sensitivities of both methods differed significantly (P = 0.001). Metastases were detected by PE in only 61 of 242 recurrences (25.2%, 95% confidence interval [CI]: 19.9–31.2%), whereas UBS revealed 240 recurrences (99.2%, 95% CI: 97.3–99.6%). The specificity was 98.4% (95% CI: 97.8–98.8%) and 98.3% (95% CI: 97.7–98.7%), respectively. Survival of 103 patients who presented with a first nodal melanoma recurrence was followed and analyzed by multiple Cox regression. Overall survival was affected by the diameter of the largest metastasis (P = 0.001) and the number of metastatic lesions (P = 0.012).
CONCLUSION
The study found that ultrasound B‐scan was highly effective in the early detection of regional melanoma metastases compared with physical examination. Earlier detection of such metastases seemed to result in improved overall survival. Cancer 2001;91:2409–16. © 2001 American Cancer Society.
Regional tumor recurrences of melanoma were detected earlier with ultrasound B‐scan than with physical examination. Better overall survival was noted in patients who had smaller metastases and a lower number of metastases.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11413532</pmid><doi>10.1002/1097-0142(20010615)91:12<2409::AID-CNCR1275>3.0.CO;2-S</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Child Female Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Melanoma - diagnosis Melanoma - diagnostic imaging Melanoma - mortality melanoma follow‐up Middle Aged Miscellaneous. Technology Neoplasm Metastasis - diagnosis overall survival Physical Examination Prognosis Sensitivity and Specificity Skin Neoplasms - diagnosis Skin Neoplasms - diagnostic imaging Skin Neoplasms - mortality Ultrasonic investigative techniques Ultrasonography ultrasound B‐scan |
| title | Efficacy of ultrasound B‐scan compared with physical examination in follow‐up of melanoma patients |
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