Cerebral blood flow velocity response to magnesium sulfate in patients after subarachnoid hemorrhage
Magnesium sulfate therapy, standard in preventing seizures in preeclampsia, is under active investigation as a neuroprotective agent. The authors studied the effect of magnesium as a cerebral vasodilator by measuring the cerebral blood flow velocity (CBFV) response to a 5g intravenous bolus of MgSO4...
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| Veröffentlicht in: | Journal of neurosurgical anesthesiology 2001-07, Vol.13 (3), p.202-206 |
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| container_title | Journal of neurosurgical anesthesiology |
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| creator | Brewer, R P Parra, A Lynch, J Chilukuri, V Borel, C O |
| description | Magnesium sulfate therapy, standard in preventing seizures in preeclampsia, is under active investigation as a neuroprotective agent. The authors studied the effect of magnesium as a cerebral vasodilator by measuring the cerebral blood flow velocity (CBFV) response to a 5g intravenous bolus of MgSO4 compared with a saline placebo after subarachnoid hemorrhage (SAH). Transcranial Doppler ultrasonography of the middle cerebral artery (MCA) was measured after each infusion. Patients were studied up to three times after SAH at prescribed time intervals. Fourteen patients (11 women, 3 men; mean age 58 years) underwent 29 studies. All patients underwent hypertensive, hypervolemic therapy. Four patients developed cerebral vasospasm. Doubling serum magnesium levels did not affect MCA CBFV but slightly lowered mean arterial blood pressure and systemic vascular resistance. Intravenous magnesium bolus did not reduce elevated CBFV in the subset of SAH patients with clinical vasospasm. The role of magnesium sulfate as a cerebral vasodilator in patients with SAH requires further study. |
| doi_str_mv | 10.1097/00008506-200107000-00004 |
| format | Article |
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The authors studied the effect of magnesium as a cerebral vasodilator by measuring the cerebral blood flow velocity (CBFV) response to a 5g intravenous bolus of MgSO4 compared with a saline placebo after subarachnoid hemorrhage (SAH). Transcranial Doppler ultrasonography of the middle cerebral artery (MCA) was measured after each infusion. Patients were studied up to three times after SAH at prescribed time intervals. Fourteen patients (11 women, 3 men; mean age 58 years) underwent 29 studies. All patients underwent hypertensive, hypervolemic therapy. Four patients developed cerebral vasospasm. Doubling serum magnesium levels did not affect MCA CBFV but slightly lowered mean arterial blood pressure and systemic vascular resistance. Intravenous magnesium bolus did not reduce elevated CBFV in the subset of SAH patients with clinical vasospasm. 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The authors studied the effect of magnesium as a cerebral vasodilator by measuring the cerebral blood flow velocity (CBFV) response to a 5g intravenous bolus of MgSO4 compared with a saline placebo after subarachnoid hemorrhage (SAH). Transcranial Doppler ultrasonography of the middle cerebral artery (MCA) was measured after each infusion. Patients were studied up to three times after SAH at prescribed time intervals. Fourteen patients (11 women, 3 men; mean age 58 years) underwent 29 studies. All patients underwent hypertensive, hypervolemic therapy. Four patients developed cerebral vasospasm. Doubling serum magnesium levels did not affect MCA CBFV but slightly lowered mean arterial blood pressure and systemic vascular resistance. Intravenous magnesium bolus did not reduce elevated CBFV in the subset of SAH patients with clinical vasospasm. 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Parra, A ; Lynch, J ; Chilukuri, V ; Borel, C O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-a275b1fe4f32813572e7bfa31250252b58f91ca127cffede02d6bf380be1a63c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Blood Flow Velocity - drug effects</topic><topic>Blood Pressure - drug effects</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Intracranial Aneurysm - etiology</topic><topic>Intracranial Aneurysm - surgery</topic><topic>Magnesium Sulfate - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Middle Cerebral Artery - diagnostic imaging</topic><topic>Middle Cerebral Artery - drug effects</topic><topic>Placebos</topic><topic>Postoperative Complications</topic><topic>Pulmonary Artery</topic><topic>Subarachnoid Hemorrhage - drug therapy</topic><topic>Subarachnoid Hemorrhage - physiopathology</topic><topic>Subarachnoid Hemorrhage - surgery</topic><topic>Ultrasonography, Doppler, Transcranial</topic><topic>Vascular Resistance - drug effects</topic><topic>Vasospasm, Intracranial - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brewer, R P</creatorcontrib><creatorcontrib>Parra, A</creatorcontrib><creatorcontrib>Lynch, J</creatorcontrib><creatorcontrib>Chilukuri, V</creatorcontrib><creatorcontrib>Borel, C O</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurosurgical anesthesiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brewer, R P</au><au>Parra, A</au><au>Lynch, J</au><au>Chilukuri, V</au><au>Borel, C O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral blood flow velocity response to magnesium sulfate in patients after subarachnoid hemorrhage</atitle><jtitle>Journal of neurosurgical anesthesiology</jtitle><addtitle>J Neurosurg Anesthesiol</addtitle><date>2001-07-01</date><risdate>2001</risdate><volume>13</volume><issue>3</issue><spage>202</spage><epage>206</epage><pages>202-206</pages><issn>0898-4921</issn><abstract>Magnesium sulfate therapy, standard in preventing seizures in preeclampsia, is under active investigation as a neuroprotective agent. The authors studied the effect of magnesium as a cerebral vasodilator by measuring the cerebral blood flow velocity (CBFV) response to a 5g intravenous bolus of MgSO4 compared with a saline placebo after subarachnoid hemorrhage (SAH). Transcranial Doppler ultrasonography of the middle cerebral artery (MCA) was measured after each infusion. Patients were studied up to three times after SAH at prescribed time intervals. Fourteen patients (11 women, 3 men; mean age 58 years) underwent 29 studies. All patients underwent hypertensive, hypervolemic therapy. Four patients developed cerebral vasospasm. Doubling serum magnesium levels did not affect MCA CBFV but slightly lowered mean arterial blood pressure and systemic vascular resistance. Intravenous magnesium bolus did not reduce elevated CBFV in the subset of SAH patients with clinical vasospasm. The role of magnesium sulfate as a cerebral vasodilator in patients with SAH requires further study.</abstract><cop>United States</cop><pmid>11426093</pmid><doi>10.1097/00008506-200107000-00004</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Aged Aged, 80 and over Anticonvulsants - therapeutic use Blood Flow Velocity - drug effects Blood Pressure - drug effects Cerebrovascular Circulation - drug effects Double-Blind Method Female Humans Intracranial Aneurysm - etiology Intracranial Aneurysm - surgery Magnesium Sulfate - therapeutic use Male Middle Aged Middle Cerebral Artery - diagnostic imaging Middle Cerebral Artery - drug effects Placebos Postoperative Complications Pulmonary Artery Subarachnoid Hemorrhage - drug therapy Subarachnoid Hemorrhage - physiopathology Subarachnoid Hemorrhage - surgery Ultrasonography, Doppler, Transcranial Vascular Resistance - drug effects Vasospasm, Intracranial - etiology |
| title | Cerebral blood flow velocity response to magnesium sulfate in patients after subarachnoid hemorrhage |
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