Canonical binding arrays as molecular recognition elements in the immune system: tetrahedral anions and the ester hydrolysis transition state

The structures, obtained by X-ray crystallography, of the binding sites of catalytic antibodies raised to bind different phosphonates are compared. Although the amino acid sequences differ, all exhibit a tetrahedral array of hydrogen bond donors (a ‘canonical binding array’) complementary to the tet...

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Veröffentlicht in:	Chemistry & Biology 2001-06, Vol.8 (6), p.535-545
Hauptverfasser:	Tantillo, Dean J, Houk, K.N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anions Antibodies - chemistry Antibodies - immunology Antibodies - metabolism Antibody Specificity Canonical binding array Crystallography, X-Ray Epitopes - chemistry Epitopes - metabolism Esters Haptens - immunology Haptens - metabolism Humans Hydrolysis Immune system Molecular recognition Protein Conformation Tetrahedral anion
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container_title	Chemistry & Biology
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creator	Tantillo, Dean J Houk, K.N
description	The structures, obtained by X-ray crystallography, of the binding sites of catalytic antibodies raised to bind different phosphonates are compared. Although the amino acid sequences differ, all exhibit a tetrahedral array of hydrogen bond donors (a ‘canonical binding array’) complementary to the tetrahedral anion, which represents a ‘transition state epitope’ for the basic hydrolysis of esters and amides. Antibodies for phosphates, arsonates, and sulfonates are found also to possess the tetrahedral anion canonical binding array.
doi_str_mv	10.1016/S1074-5521(01)00035-7
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subjects	Animals Anions Antibodies - chemistry Antibodies - immunology Antibodies - metabolism Antibody Specificity Canonical binding array Crystallography, X-Ray Epitopes - chemistry Epitopes - metabolism Esters Haptens - immunology Haptens - metabolism Humans Hydrolysis Immune system Molecular recognition Protein Conformation Tetrahedral anion
title	Canonical binding arrays as molecular recognition elements in the immune system: tetrahedral anions and the ester hydrolysis transition state
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