Analysis of Multiple Samples Using Multiplex Sample NMR:  Selective Excitation and Chemical Shift Imaging Approaches

Two improved approaches for the rapid analysis of multiple samples using multiplex sample NMR are described. In the first approach, frequency-selective 90° radio frequency pulses and large pulsed field gradients are applied to excite and detect multiple samples in rapid succession. This method is ad...

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Veröffentlicht in:Analytical chemistry (Washington) 2001-06, Vol.73 (11), p.2541-2546
Hauptverfasser: Hou, Ting, Smith, Jay, MacNamara, Ernesto, Macnaughtan, Megan, Raftery, Daniel
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creator Hou, Ting
Smith, Jay
MacNamara, Ernesto
Macnaughtan, Megan
Raftery, Daniel
description Two improved approaches for the rapid analysis of multiple samples using multiplex sample NMR are described. In the first approach, frequency-selective 90° radio frequency pulses and large pulsed field gradients are applied to excite and detect multiple samples in rapid succession. This method is advantageous for samples with relatively long longitudinal (T 1) relaxation times. In the second approach, chemical shift imaging is applied to acquire both the spectral and spatial information of multiple samples simultaneously. Chemical shift imaging is more time-consuming than selective excitation; however, it is advantageous for detecting samples with short T 1's and for signal averaging. Both approaches demonstrate the potential of multiplex sample NMR for carrying out high-throughput NMR detection.
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source American Chemical Society Journals
subjects Analytical chemistry
Chemistry
Exact sciences and technology
NMR
Nuclear magnetic resonance
Scientific imaging
Spectrometric and optical methods
title Analysis of Multiple Samples Using Multiplex Sample NMR:  Selective Excitation and Chemical Shift Imaging Approaches
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