Measurement of Striatal and Extrastriatal Dopamine D1 Receptor Binding Potential With [11C]NNC 112 in Humans: Validation and Reproducibility

To evaluate the postulated role of extrastriatal D1 receptors in human cognition and psychopathology requires an accurate and reliable method for quantification of these receptors in the living human brain. [11C]NNC 112 is a promising novel radiotracer for positron emission tomography imaging of the...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2000-02, Vol.20 (2), p.225-243
Hauptverfasser:	Abi-Dargham, Anissa, Martinez, Diana, Mawlawi, Osama, Simpson, Norman, Hwang, Dah-Ren, Slifstein, Mark, Anjilvel, Satish, Pidcock, Justine, Guo, Ning-Ning, Lombardo, Ilise, Mann, J. John, Van Heertum, Ronald, Foged, Christian, Halldin, Christer, Laruelle, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Benzazepines - blood Benzazepines - pharmacokinetics Benzofurans - blood Benzofurans - pharmacokinetics Biological and medical sciences Carbon Radioisotopes Cerebellum - chemistry Cerebellum - diagnostic imaging Cerebellum - metabolism Corpus Striatum - chemistry Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism Dopamine Antagonists - pharmacokinetics Female Humans Investigative techniques, diagnostic techniques (general aspects) Kinetics Male Medical sciences Middle Aged Neocortex - chemistry Neocortex - diagnostic imaging Neocortex - metabolism Osteoarticular system. Muscles Radiodiagnosis. Nmr imagery. Nmr spectrometry Radioligand Assay - methods Radioligand Assay - standards Receptors, Dopamine D1 - metabolism Reproducibility of Results Tomography, Emission-Computed - methods Tomography, Emission-Computed - standards
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