Brain allopregnanolone regulates the potency of the GABA A receptor agonist muscimol

Allopregnanolone (ALLO), a potent positive-allosteric modulator of the action of GABA at GABA A receptors, is synthesized in the brain from progesterone by the sequential action of two enzymes: 5α-reductase and 3 α-hydroxysteroidoxidoreductase. The concentration of ALLO in various parts of the mouse...

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Veröffentlicht in:	Neuropharmacology 2000-01, Vol.39 (3), p.440-448
Hauptverfasser:	Pinna, G, Uzunova, V, Matsumoto, K, Puia, G, Mienville, J.-M, Costa, E, Guidotti, A
Format:	Artikel
Sprache:	eng
Schlagworte:	5-alpha-Dihydroprogesterone 5α-Reductase Animals Brain - drug effects Brain - metabolism Enzyme Inhibitors - pharmacology GABA A receptors GABA Agonists - pharmacology Male Mice Muscimol Muscimol - pharmacology Neurosteroids Pregnanediones - metabolism Pregnanolone - biosynthesis Pyramidal Cells - drug effects Pyramidal Cells - physiology Receptors, GABA-A - drug effects Receptors, GABA-A - metabolism SKF 105,111 Synaptic Transmission - drug effects Synaptic Transmission - physiology
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