Fas ligand–induced caspase-1–dependent accumulation of interleukin-18 in mice with acute graft-versus-host disease
Acute graft-versus-host disease (aGVHD), the fatal side effects of bone marrow transplantation, was shown to be accompanied by elevation of serum levels of interleukin 18 (IL-18). In this study, the mechanism underlying the accumulation of IL-18 in aGVHD in mice was investigated. Lethally irradiated...
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| Veröffentlicht in: | Blood 2001-07, Vol.98 (1), p.235-237 |
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| creator | Itoi, Hisayuki Fujimori, Yoshihiro Tsutsui, Hiroko Matsui, Kiyoshi Futatsugi, Shizue Okamura, Haruki Hara, Hiroshi Hada, Toshikazu Kakishita, Eizo Nakanishi, Kenji |
| description | Acute graft-versus-host disease (aGVHD), the fatal side effects of bone marrow transplantation, was shown to be accompanied by elevation of serum levels of interleukin 18 (IL-18). In this study, the mechanism underlying the accumulation of IL-18 in aGVHD in mice was investigated. Lethally irradiated recipients having transplantation with H-2 disparate donor splenocytes demonstrated aGVHD and contained markedly elevated serum levels of IL-18. In contrast, recipients having transplantation with gld/gld spleen cells, which lack functional Fas ligand (FasL), contained only normal ranges of IL-18, indicating FasL-mediated IL-18 release in aGVHD. The wild-type hosts engrafted with caspase-1–deficient cells revealed marked increases of IL-18 similar to those engrafted with wild-type cells, whereas caspase-1–deficient recipients engrafted with wild-type cells showed only a slight elevation of serum IL-18, indicating that IL-18 elevation is derived from host cells in a caspase-1–dependent manner. These results suggest FasL-mediated caspase-1–dependent IL-18 secretion in aGVHD in mice. |
| doi_str_mv | 10.1182/blood.V98.1.235 |
| format | Article |
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In this study, the mechanism underlying the accumulation of IL-18 in aGVHD in mice was investigated. Lethally irradiated recipients having transplantation with H-2 disparate donor splenocytes demonstrated aGVHD and contained markedly elevated serum levels of IL-18. In contrast, recipients having transplantation with gld/gld spleen cells, which lack functional Fas ligand (FasL), contained only normal ranges of IL-18, indicating FasL-mediated IL-18 release in aGVHD. The wild-type hosts engrafted with caspase-1–deficient cells revealed marked increases of IL-18 similar to those engrafted with wild-type cells, whereas caspase-1–deficient recipients engrafted with wild-type cells showed only a slight elevation of serum IL-18, indicating that IL-18 elevation is derived from host cells in a caspase-1–dependent manner. These results suggest FasL-mediated caspase-1–dependent IL-18 secretion in aGVHD in mice.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.V98.1.235</identifier><identifier>PMID: 11418486</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Acute Disease ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Caspase 1 - pharmacology ; Disease Models, Animal ; Fas Ligand Protein ; Female ; Graft vs Host Disease - blood ; Interleukin-18 - blood ; Medical sciences ; Membrane Glycoproteins - pharmacology ; Mice ; Mice, Mutant Strains ; Tissue Transplantation - adverse effects ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><ispartof>Blood, 2001-07, Vol.98 (1), p.235-237</ispartof><rights>2001 American Society of Hematology</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-9db4f87b5f77b2351763232f45fc25a5e91da7f627454c83a66ac9fb3aa9c8143</citedby><cites>FETCH-LOGICAL-c413t-9db4f87b5f77b2351763232f45fc25a5e91da7f627454c83a66ac9fb3aa9c8143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1077121$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11418486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Itoi, Hisayuki</creatorcontrib><creatorcontrib>Fujimori, Yoshihiro</creatorcontrib><creatorcontrib>Tsutsui, Hiroko</creatorcontrib><creatorcontrib>Matsui, Kiyoshi</creatorcontrib><creatorcontrib>Futatsugi, Shizue</creatorcontrib><creatorcontrib>Okamura, Haruki</creatorcontrib><creatorcontrib>Hara, Hiroshi</creatorcontrib><creatorcontrib>Hada, Toshikazu</creatorcontrib><creatorcontrib>Kakishita, Eizo</creatorcontrib><creatorcontrib>Nakanishi, Kenji</creatorcontrib><title>Fas ligand–induced caspase-1–dependent accumulation of interleukin-18 in mice with acute graft-versus-host disease</title><title>Blood</title><addtitle>Blood</addtitle><description>Acute graft-versus-host disease (aGVHD), the fatal side effects of bone marrow transplantation, was shown to be accompanied by elevation of serum levels of interleukin 18 (IL-18). In this study, the mechanism underlying the accumulation of IL-18 in aGVHD in mice was investigated. Lethally irradiated recipients having transplantation with H-2 disparate donor splenocytes demonstrated aGVHD and contained markedly elevated serum levels of IL-18. In contrast, recipients having transplantation with gld/gld spleen cells, which lack functional Fas ligand (FasL), contained only normal ranges of IL-18, indicating FasL-mediated IL-18 release in aGVHD. The wild-type hosts engrafted with caspase-1–deficient cells revealed marked increases of IL-18 similar to those engrafted with wild-type cells, whereas caspase-1–deficient recipients engrafted with wild-type cells showed only a slight elevation of serum IL-18, indicating that IL-18 elevation is derived from host cells in a caspase-1–dependent manner. These results suggest FasL-mediated caspase-1–dependent IL-18 secretion in aGVHD in mice.</description><subject>Acute Disease</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Caspase 1 - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Fas Ligand Protein</subject><subject>Female</subject><subject>Graft vs Host Disease - blood</subject><subject>Interleukin-18 - blood</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - pharmacology</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Tissue Transplantation - adverse effects</subject><subject>Transfusions. Complications. Transfusion reactions. 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Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Itoi, Hisayuki</creatorcontrib><creatorcontrib>Fujimori, Yoshihiro</creatorcontrib><creatorcontrib>Tsutsui, Hiroko</creatorcontrib><creatorcontrib>Matsui, Kiyoshi</creatorcontrib><creatorcontrib>Futatsugi, Shizue</creatorcontrib><creatorcontrib>Okamura, Haruki</creatorcontrib><creatorcontrib>Hara, Hiroshi</creatorcontrib><creatorcontrib>Hada, Toshikazu</creatorcontrib><creatorcontrib>Kakishita, Eizo</creatorcontrib><creatorcontrib>Nakanishi, Kenji</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Itoi, Hisayuki</au><au>Fujimori, Yoshihiro</au><au>Tsutsui, Hiroko</au><au>Matsui, Kiyoshi</au><au>Futatsugi, Shizue</au><au>Okamura, Haruki</au><au>Hara, Hiroshi</au><au>Hada, Toshikazu</au><au>Kakishita, Eizo</au><au>Nakanishi, Kenji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fas ligand–induced caspase-1–dependent accumulation of interleukin-18 in mice with acute graft-versus-host disease</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>2001-07-01</date><risdate>2001</risdate><volume>98</volume><issue>1</issue><spage>235</spage><epage>237</epage><pages>235-237</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Acute graft-versus-host disease (aGVHD), the fatal side effects of bone marrow transplantation, was shown to be accompanied by elevation of serum levels of interleukin 18 (IL-18). In this study, the mechanism underlying the accumulation of IL-18 in aGVHD in mice was investigated. Lethally irradiated recipients having transplantation with H-2 disparate donor splenocytes demonstrated aGVHD and contained markedly elevated serum levels of IL-18. In contrast, recipients having transplantation with gld/gld spleen cells, which lack functional Fas ligand (FasL), contained only normal ranges of IL-18, indicating FasL-mediated IL-18 release in aGVHD. The wild-type hosts engrafted with caspase-1–deficient cells revealed marked increases of IL-18 similar to those engrafted with wild-type cells, whereas caspase-1–deficient recipients engrafted with wild-type cells showed only a slight elevation of serum IL-18, indicating that IL-18 elevation is derived from host cells in a caspase-1–dependent manner. These results suggest FasL-mediated caspase-1–dependent IL-18 secretion in aGVHD in mice.</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>11418486</pmid><doi>10.1182/blood.V98.1.235</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Disease Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Bone marrow, stem cells transplantation. Graft versus host reaction Caspase 1 - pharmacology Disease Models, Animal Fas Ligand Protein Female Graft vs Host Disease - blood Interleukin-18 - blood Medical sciences Membrane Glycoproteins - pharmacology Mice Mice, Mutant Strains Tissue Transplantation - adverse effects Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | Fas ligand–induced caspase-1–dependent accumulation of interleukin-18 in mice with acute graft-versus-host disease |
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