Immediate Early Gene Expression in PC12 Cells Exposed to Lead: Requirement for Protein Kinase C

We previously demonstrated induction of c‐fos mRNA in PC12 cells exposed to lead that was dependent on new transcription. In the current work, we examined two signal transduction mechanisms that are activated by lead and have been shown to mediate induction of c‐fos mRNA. One mechanism involves prot...

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Veröffentlicht in:	Journal of neurochemistry 2000-03, Vol.74 (3), p.1140-1146
Hauptverfasser:	Kim, Kyung‐Ah, Chakraborti, Tamal, Goldstein, Gary W., Bressler, Joseph P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Cerebellum - cytology Cerebellum - physiology Chemical and industrial products toxicology. Toxic occupational diseases DNA - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Early Growth Response Protein 1 Gene Expression - drug effects Gene Expression Regulation Genes, fos - genetics Genes, Immediate-Early - genetics Genes, jun - genetics Genes, Reporter - physiology immediate early genes Immediate early response gene Immediate-Early Proteins Lead Lead - pharmacology Luciferases - genetics Medical sciences Metals and various inorganic compounds PC12 Cells - drug effects PC12 Cells - physiology Plasmids - physiology Protein kinase Protein Kinase C - physiology Rats RNA, Messenger - metabolism Toxicology Transcription Factor AP-1 - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic - physiology
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