Extreme geographical fixation of variation in the Plasmodium falciparum gamete surface protein gene Pfs48/45 compared with microsatellite loci

Comparing patterns of genetic variation at multiple loci in the genome of a species can potentially identify loci which are under selection. The large number of polymorphic microsatellites in the malaria parasite Plasmodium falciparum are available markers to screen for selectively important loci. T...

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Veröffentlicht in:	Molecular and biochemical parasitology 2001-07, Vol.115 (2), p.145-156
Hauptverfasser:	Conway, David J., Machado, Ricardo L.D., Singh, Balbir, Dessert, Patricia, Mikes, Zsuzsanna S., Povoa, Marinete M., Oduola, Ayoade M.J., Roper, Cally
Format:	Artikel
Sprache:	eng
Schlagworte:	Africa - epidemiology Alleles Animals Brazil - epidemiology Chromosome 13 Gametes Gene Frequency Genetic Variation - genetics Genetics Genetics, Population Haplotypes Humans Malaria, Falciparum - epidemiology Malaria, Falciparum - parasitology Malaysia - epidemiology Membrane Glycoproteins - genetics Microsatellite Repeats - genetics Microsatellites Pfs48/45 Pfs48/45 gene Plasmodium falciparum Plasmodium falciparum - genetics Plasmodium falciparum - growth & development Polymorphism, Single Nucleotide Protozoan Proteins - genetics Selection
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