The role of cGMP hydrolysing phosphodiesterases 1 and 5 in cerebral artery dilatation

The aim was to investigate the presence and activity of cGMP hydrolysing phosphodiesterases in guinea pig basilar arteries and the effect of selective and non-selective phosphodiesterase inhibitors on cerebral artery dilatation involving the nitric oxide (NO)–guanosine cyclic 3′5-monophosphate (cGMP...

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Veröffentlicht in:	European journal of pharmacology 2001-05, Vol.420 (1), p.55-65
Hauptverfasser:	Kruuse, Christina, Rybalkin, Sergei D, Khurana, Tejvir S, Jansen-Olesen, Inger, Olesen, Jes, Edvinsson, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - pharmacology 3',5'-Cyclic-GMP Phosphodiesterases - antagonists & inhibitors 3',5'-Cyclic-GMP Phosphodiesterases - metabolism Animals Basilar Artery - enzymology Biological and medical sciences Cardiovascular system Cerebral Arteries - drug effects Cerebral Arteries - physiology Cerebral artery cGMP Cyclic AMP - metabolism Cyclic GMP - metabolism Dipyridamole - pharmacology Dose-Response Relationship, Drug Endothelium, Vascular - physiology Enzyme Inhibitors - pharmacology Guanylate Cyclase - drug effects Guanylate Cyclase - metabolism Guinea Pigs In Vitro Techniques Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Male Medical sciences Milrinone - pharmacology Nitric oxide (NO) Nitroprusside - pharmacology Oxadiazoles - pharmacology Pentoxifylline - pharmacology Pharmacology. Drug treatments Phosphodiesterase Phosphodiesterase inhibitor Phosphodiesterase Inhibitors - pharmacology Purinones - pharmacology Quinoxalines - pharmacology Vasodilatation Vasodilation - drug effects Vasodilator Agents - pharmacology Vasodilator agents. Cerebral vasodilators
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