Sema3C and Netrin-1 Differentially Affect Axon Growth in the Hippocampal Formation
The interaction between outgrowing neurons and their targets is a central element in the development of the afferent and efferent connections of the hippocampal system. This requires that axonal growth cones recognize specific guidance cues in the appropriate target area. At present, little is known...
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| Veröffentlicht in: | Molecular and cellular neuroscience 2000-02, Vol.15 (2), p.141-155 |
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| creator | Steup, Andreas Lohrum, Marion Hamscho, Nadja Savaskan, Nicolai E. Ninnemann, Olaf Nitsch, Robert Fujisawa, Hajime Püschel, Andreas W. Skutella, Thomas |
| description | The interaction between outgrowing neurons and their targets is a central element in the development of the afferent and efferent connections of the hippocampal system. This requires that axonal growth cones recognize specific guidance cues in the appropriate target area. At present, little is known about the mechanisms that determine the lamina-specific termination of hippocampal afferents. In order to understand the role of different guidance factors, we analyzed the effects of Sema3C and Netrin-1 on explants from the entorhinal cortex, dentate gyrus, cornu ammonis regions CA1 and CA3 and medial septum in a collagen coculture assay. Our observations suggest that both semaphorins and netrin play important roles in the neuron–target interactions in the hippocampal system. Sema3C is involved in the control of the ingrowth of the septohippocampal projection. We also show that netrin-1 is involved in attracting commissural neurons from dentate gyrus/hilus and CA3 to their target area in the contralateral hippocampus. |
| doi_str_mv | 10.1006/mcne.1999.0818 |
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This requires that axonal growth cones recognize specific guidance cues in the appropriate target area. At present, little is known about the mechanisms that determine the lamina-specific termination of hippocampal afferents. In order to understand the role of different guidance factors, we analyzed the effects of Sema3C and Netrin-1 on explants from the entorhinal cortex, dentate gyrus, cornu ammonis regions CA1 and CA3 and medial septum in a collagen coculture assay. Our observations suggest that both semaphorins and netrin play important roles in the neuron–target interactions in the hippocampal system. Sema3C is involved in the control of the ingrowth of the septohippocampal projection. 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We also show that netrin-1 is involved in attracting commissural neurons from dentate gyrus/hilus and CA3 to their target area in the contralateral hippocampus.</description><subject>Animals</subject><subject>Axons - physiology</subject><subject>Base Sequence</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - physiology</subject><subject>Cell Aggregation</subject><subject>Cells, Cultured</subject><subject>Coculture Techniques</subject><subject>Embryo, Mammalian</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - growth & development</subject><subject>Humans</subject><subject>Molecular Sequence Data</subject><subject>Nerve Growth Factors - genetics</subject><subject>Nerve Growth Factors - physiology</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>Netrin-1</subject><subject>Neurons - cytology</subject><subject>Neurons - physiology</subject><subject>Oligodeoxyribonucleotides</subject><subject>Organ Culture Techniques</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>semaphorin 3C</subject><subject>Semaphorin-3A</subject><subject>Transfection</subject><subject>Tumor Suppressor Proteins</subject><issn>1044-7431</issn><issn>1095-9327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLlu3DAQQIkgRnylTRmwSqf1jKgVyXKx8QUYCeCjJihqBDOQSJnU2vHfR8K6cBO4mhngzSseY98QVghQnw0u0Aq11itQqD6xIwS9LrQo5edlr6pCVgIP2XHOfwBgXWrxhR0i1FKIUhyx2zsarNhyG1r-i6bkQ4H8p-86ShQmb_v-lW_my0188zcGfpniy_TIfeDTI_ErP47R2WG0Pb-IabCTj-GUHXS2z_T1bZ6wh4vz--1VcfP78nq7uSlcJeRUNEpbVLpsNZKWUq0rCzVq6rCua2gUECiFjWxk3WLbEtqmrLTSWtXggCpxwn7svWOKTzvKkxl8dtT3NlDcZSNBCwkKPgRRVmotcTGu9qBLMedEnRmTH2x6NQhmyW2W3GbJbZbc88P3N_OuGah9h-_7zoDaAzSHePaUTHaegqPWp7mpaaP_n_sfY9-MvA</recordid><startdate>20000201</startdate><enddate>20000201</enddate><creator>Steup, Andreas</creator><creator>Lohrum, Marion</creator><creator>Hamscho, Nadja</creator><creator>Savaskan, Nicolai E.</creator><creator>Ninnemann, Olaf</creator><creator>Nitsch, Robert</creator><creator>Fujisawa, Hajime</creator><creator>Püschel, Andreas W.</creator><creator>Skutella, Thomas</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20000201</creationdate><title>Sema3C and Netrin-1 Differentially Affect Axon Growth in the Hippocampal Formation</title><author>Steup, Andreas ; 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This requires that axonal growth cones recognize specific guidance cues in the appropriate target area. At present, little is known about the mechanisms that determine the lamina-specific termination of hippocampal afferents. In order to understand the role of different guidance factors, we analyzed the effects of Sema3C and Netrin-1 on explants from the entorhinal cortex, dentate gyrus, cornu ammonis regions CA1 and CA3 and medial septum in a collagen coculture assay. Our observations suggest that both semaphorins and netrin play important roles in the neuron–target interactions in the hippocampal system. Sema3C is involved in the control of the ingrowth of the septohippocampal projection. 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| subjects | Animals Axons - physiology Base Sequence Carrier Proteins - genetics Carrier Proteins - physiology Cell Aggregation Cells, Cultured Coculture Techniques Embryo, Mammalian Gene Expression Regulation, Developmental Hippocampus - cytology Hippocampus - growth & development Humans Molecular Sequence Data Nerve Growth Factors - genetics Nerve Growth Factors - physiology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Netrin-1 Neurons - cytology Neurons - physiology Oligodeoxyribonucleotides Organ Culture Techniques Rats Rats, Wistar semaphorin 3C Semaphorin-3A Transfection Tumor Suppressor Proteins |
| title | Sema3C and Netrin-1 Differentially Affect Axon Growth in the Hippocampal Formation |
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