Investigation of pharmaceutical high-performance liquid chromatography assay bias using experimental design

This article presents a systematic approach to investigate, document, and eliminate pharmaceutical HPLC assay bias using experimental design. This is the first article to describe the application of experimental design in the area of assay bias. It is found that both formulation and analytical varia...

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Veröffentlicht in:	Journal of Chromatography A 2001-05, Vol.917 (1), p.63-73
Hauptverfasser:	Chen, Jian-Ge, Glancy, Kelly, Chen, Xiaohong, Alasandro, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological and medical sciences Chromatography, High Pressure Liquid - methods DMP 543 General pharmacology Medical sciences Pharmaceutical Preparations - chemistry Pharmacology. Drug treatments Reproducibility of Results Spectrophotometry, Ultraviolet XP 280
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	This article presents a systematic approach to investigate, document, and eliminate pharmaceutical HPLC assay bias using experimental design. This is the first article to describe the application of experimental design in the area of assay bias. It is found that both formulation and analytical variables can contribute to pharmaceutical HPLC assay bias using model compounds and formulations.
ISSN:	0021-9673
DOI:	10.1016/S0021-9673(01)00670-7