Antimicrobial Activities of Some Amino Derivatives of 5, 7-Dibromo-2-methyl-8-hydroxyquinoline
The bromine atoms of the title compound, 5, 7-dibromo-2-methyl-8-hydroxyquinoline were replaced by the requisite amino compound to afford 6 amino derivatives viz : bis(diethylamino)-, bis(dibutylamino)-, bis(dicyclohexylamino)-, dipyrolidino-, dipiperidino- and dipiperazino derivatives. The antimicr...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2000/02/01, Vol.23(2), pp.257-258 |
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| creator | OKIDE, George B. ADIKWU, Michael U. ESIMONE, Charles O. |
| description | The bromine atoms of the title compound, 5, 7-dibromo-2-methyl-8-hydroxyquinoline were replaced by the requisite amino compound to afford 6 amino derivatives viz : bis(diethylamino)-, bis(dibutylamino)-, bis(dicyclohexylamino)-, dipyrolidino-, dipiperidino- and dipiperazino derivatives. The antimicrobial activity of these compounds were investigated against selected Gram positive (Staphylococcus aureus and Bacillus subtilis), Gram negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and yeast (Candida albicans). All the compounds showed significant activity against the test microorganisms, from 5-30 times compared to the title compound. It was observed that all derivatives were more effective against Gram positive bacteria. No correlation has been established between the minimum inhibitory (MIC) concentrations of the derivatives and the structural modifications. |
| doi_str_mv | 10.1248/bpb.23.257 |
| format | Article |
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The antimicrobial activity of these compounds were investigated against selected Gram positive (Staphylococcus aureus and Bacillus subtilis), Gram negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and yeast (Candida albicans). All the compounds showed significant activity against the test microorganisms, from 5-30 times compared to the title compound. It was observed that all derivatives were more effective against Gram positive bacteria. No correlation has been established between the minimum inhibitory (MIC) concentrations of the derivatives and the structural modifications.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.23.257</identifier><identifier>PMID: 10706397</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>5, 7-dibromo-2-methyl-8-hydroxyquinoline ; amino derivative ; Anti-Bacterial Agents - pharmacology ; Anti-Infective Agents - chemical synthesis ; Anti-Infective Agents - pharmacology ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal Agents - chemical synthesis ; Antifungal Agents - pharmacology ; antimicrobial activity ; Bacillus subtilis ; Bacteria - drug effects ; Biological and medical sciences ; Candida - drug effects ; Candida albicans ; Culture Media ; Escherichia coli ; Hydroxyquinolines - chemical synthesis ; Hydroxyquinolines - pharmacology ; Medical sciences ; Microbial Sensitivity Tests ; Pharmacology. Drug treatments ; Pseudomonas aeruginosa ; Staphylococcus aureus</subject><ispartof>Biological and Pharmaceutical Bulletin, 2000/02/01, Vol.23(2), pp.257-258</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>2000 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c634t-cfd87dfba0b99d4b5f62acddb9dbe2515f8de62fcfca760b304a88906a1676dc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1297167$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10706397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OKIDE, George B.</creatorcontrib><creatorcontrib>ADIKWU, Michael U.</creatorcontrib><creatorcontrib>ESIMONE, Charles O.</creatorcontrib><title>Antimicrobial Activities of Some Amino Derivatives of 5, 7-Dibromo-2-methyl-8-hydroxyquinoline</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The bromine atoms of the title compound, 5, 7-dibromo-2-methyl-8-hydroxyquinoline were replaced by the requisite amino compound to afford 6 amino derivatives viz : bis(diethylamino)-, bis(dibutylamino)-, bis(dicyclohexylamino)-, dipyrolidino-, dipiperidino- and dipiperazino derivatives. The antimicrobial activity of these compounds were investigated against selected Gram positive (Staphylococcus aureus and Bacillus subtilis), Gram negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and yeast (Candida albicans). All the compounds showed significant activity against the test microorganisms, from 5-30 times compared to the title compound. It was observed that all derivatives were more effective against Gram positive bacteria. No correlation has been established between the minimum inhibitory (MIC) concentrations of the derivatives and the structural modifications.</description><subject>5, 7-dibromo-2-methyl-8-hydroxyquinoline</subject><subject>amino derivative</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Infective Agents - chemical synthesis</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal Agents - chemical synthesis</subject><subject>Antifungal Agents - pharmacology</subject><subject>antimicrobial activity</subject><subject>Bacillus subtilis</subject><subject>Bacteria - drug effects</subject><subject>Biological and medical sciences</subject><subject>Candida - drug effects</subject><subject>Candida albicans</subject><subject>Culture Media</subject><subject>Escherichia coli</subject><subject>Hydroxyquinolines - chemical synthesis</subject><subject>Hydroxyquinolines - pharmacology</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Pseudomonas aeruginosa</topic><topic>Staphylococcus aureus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OKIDE, George B.</creatorcontrib><creatorcontrib>ADIKWU, Michael U.</creatorcontrib><creatorcontrib>ESIMONE, Charles O.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OKIDE, George B.</au><au>ADIKWU, Michael U.</au><au>ESIMONE, Charles O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial Activities of Some Amino Derivatives of 5, 7-Dibromo-2-methyl-8-hydroxyquinoline</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2000-02-01</date><risdate>2000</risdate><volume>23</volume><issue>2</issue><spage>257</spage><epage>258</epage><pages>257-258</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>The bromine atoms of the title compound, 5, 7-dibromo-2-methyl-8-hydroxyquinoline were replaced by the requisite amino compound to afford 6 amino derivatives viz : bis(diethylamino)-, bis(dibutylamino)-, bis(dicyclohexylamino)-, dipyrolidino-, dipiperidino- and dipiperazino derivatives. The antimicrobial activity of these compounds were investigated against selected Gram positive (Staphylococcus aureus and Bacillus subtilis), Gram negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and yeast (Candida albicans). All the compounds showed significant activity against the test microorganisms, from 5-30 times compared to the title compound. It was observed that all derivatives were more effective against Gram positive bacteria. No correlation has been established between the minimum inhibitory (MIC) concentrations of the derivatives and the structural modifications.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>10706397</pmid><doi>10.1248/bpb.23.257</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Free Full-Text Journals in Chemistry |
| subjects | 5, 7-dibromo-2-methyl-8-hydroxyquinoline amino derivative Anti-Bacterial Agents - pharmacology Anti-Infective Agents - chemical synthesis Anti-Infective Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal Agents - chemical synthesis Antifungal Agents - pharmacology antimicrobial activity Bacillus subtilis Bacteria - drug effects Biological and medical sciences Candida - drug effects Candida albicans Culture Media Escherichia coli Hydroxyquinolines - chemical synthesis Hydroxyquinolines - pharmacology Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Pseudomonas aeruginosa Staphylococcus aureus |
| title | Antimicrobial Activities of Some Amino Derivatives of 5, 7-Dibromo-2-methyl-8-hydroxyquinoline |
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