Treatment of acute Nipah encephalitis with ribavirin
Nipah virus, a newly identified paramyxovirus caused a severe outbreak of encephalitis in Malaysia with high fatalities. We report an open‐label trial of ribavirin in 140 patients, with 54 patients who were managed prior to the availability of ribavirin or refused treatment as control. There were 45...
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| Veröffentlicht in: | Annals of neurology 2001-06, Vol.49 (6), p.810-813 |
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| container_issue | 6 |
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| container_title | Annals of neurology |
| container_volume | 49 |
| creator | Chong, Heng-Thay Kamarulzaman, Adeeba Tan, Chong-Tin Goh, Khean-Jin Thayaparan, Tarmizi Kunjapan, Sree Raman Chew, Nee-Kong Chua, Kaw-Bing Lam, Sai-Kit |
| description | Nipah virus, a newly identified paramyxovirus caused a severe outbreak of encephalitis in Malaysia with high fatalities. We report an open‐label trial of ribavirin in 140 patients, with 54 patients who were managed prior to the availability of ribavirin or refused treatment as control. There were 45 deaths (32%) in the ribavirin arm; 29 deaths (54%) occurred in the control arm. This represents a 36% reduction in mortality (p = 0.011). There was no associated serious side effect. This study suggests that ribavirin is able to reduce the mortality of acute Nipah encephalitis. |
| doi_str_mv | 10.1002/ana.1062 |
| format | Article |
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We report an open‐label trial of ribavirin in 140 patients, with 54 patients who were managed prior to the availability of ribavirin or refused treatment as control. There were 45 deaths (32%) in the ribavirin arm; 29 deaths (54%) occurred in the control arm. This represents a 36% reduction in mortality (p = 0.011). There was no associated serious side effect. This study suggests that ribavirin is able to reduce the mortality of acute Nipah encephalitis.</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.1062</identifier><identifier>PMID: 11409437</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adult ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Asian Continental Ancestry Group ; Biological and medical sciences ; China - ethnology ; Encephalitis, Viral - drug therapy ; Encephalitis, Viral - mortality ; Encephalitis, Viral - physiopathology ; Encephalitis, Viral - virology ; Female ; Human viral diseases ; Humans ; Infectious diseases ; Malaysia ; Male ; Medical sciences ; Paramyxovirinae - classification ; Paramyxovirinae - isolation & purification ; Paramyxovirinae - physiology ; Pharmacology. Drug treatments ; Retrospective Studies ; Ribavirin - adverse effects ; Ribavirin - therapeutic use ; Treatment Outcome ; Treatment Refusal ; Tropical medicine ; Viral diseases ; Viral diseases of the nervous system</subject><ispartof>Annals of neurology, 2001-06, Vol.49 (6), p.810-813</ispartof><rights>Copyright © 2001 Wiley‐Liss, Inc.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3842-d4b422450ae1c7d4762dceb80b7f71db0602d3f106cf267829f6a58cc228fc443</citedby><cites>FETCH-LOGICAL-c3842-d4b422450ae1c7d4762dceb80b7f71db0602d3f106cf267829f6a58cc228fc443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.1062$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.1062$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1006502$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11409437$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chong, Heng-Thay</creatorcontrib><creatorcontrib>Kamarulzaman, Adeeba</creatorcontrib><creatorcontrib>Tan, Chong-Tin</creatorcontrib><creatorcontrib>Goh, Khean-Jin</creatorcontrib><creatorcontrib>Thayaparan, Tarmizi</creatorcontrib><creatorcontrib>Kunjapan, Sree Raman</creatorcontrib><creatorcontrib>Chew, Nee-Kong</creatorcontrib><creatorcontrib>Chua, Kaw-Bing</creatorcontrib><creatorcontrib>Lam, Sai-Kit</creatorcontrib><title>Treatment of acute Nipah encephalitis with ribavirin</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>Nipah virus, a newly identified paramyxovirus caused a severe outbreak of encephalitis in Malaysia with high fatalities. We report an open‐label trial of ribavirin in 140 patients, with 54 patients who were managed prior to the availability of ribavirin or refused treatment as control. There were 45 deaths (32%) in the ribavirin arm; 29 deaths (54%) occurred in the control arm. This represents a 36% reduction in mortality (p = 0.011). There was no associated serious side effect. This study suggests that ribavirin is able to reduce the mortality of acute Nipah encephalitis.</description><subject>Adult</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Asian Continental Ancestry Group</subject><subject>Biological and medical sciences</subject><subject>China - ethnology</subject><subject>Encephalitis, Viral - drug therapy</subject><subject>Encephalitis, Viral - mortality</subject><subject>Encephalitis, Viral - physiopathology</subject><subject>Encephalitis, Viral - virology</subject><subject>Female</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Malaysia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Paramyxovirinae - classification</subject><subject>Paramyxovirinae - isolation & purification</subject><subject>Paramyxovirinae - physiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Retrospective Studies</subject><subject>Ribavirin - adverse effects</subject><subject>Ribavirin - therapeutic use</subject><subject>Treatment Outcome</subject><subject>Treatment Refusal</subject><subject>Tropical medicine</subject><subject>Viral diseases</subject><subject>Viral diseases of the nervous system</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E9PwjAYBvDGaATRxE9gdjDGy_Ttn7XbkaCghmBMMBybrmtDdQxsh8i3d4RFvXjqe_jled8-CJ1juMEA5FZVqhk4OUBdnFAcp4Rlh6gLlLM4wZR10EkIbwCQcQzHqIMxg4xR0UVs6o2qF6aqo6WNlF7XJpq4lZpHptJmNVelq12INq6eR97l6tN5V52iI6vKYM7at4deh_fTwUM8fh49DvrjWNOUkbhgOSOEJaAM1qJggpNCmzyFXFiBixw4kILa5nBtCRcpySxXSao1IanVjNEeutrnrvzyY21CLRcuaFOWqjLLdZACMtp8hDTweg-1X4bgjZUr7xbKbyUGuWtINg3JXUMNvWgz1_nCFL-wraQBly1QQavSelVpF_4EAk9glxPv2caVZvvvPtmf9Nu9rXehNl8_Xvl3yQUViZxNRvLuhTxNs9lQEvoN23KJYQ</recordid><startdate>200106</startdate><enddate>200106</enddate><creator>Chong, Heng-Thay</creator><creator>Kamarulzaman, Adeeba</creator><creator>Tan, Chong-Tin</creator><creator>Goh, Khean-Jin</creator><creator>Thayaparan, Tarmizi</creator><creator>Kunjapan, Sree Raman</creator><creator>Chew, Nee-Kong</creator><creator>Chua, Kaw-Bing</creator><creator>Lam, Sai-Kit</creator><general>John Wiley & Sons, Inc</general><general>Willey-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200106</creationdate><title>Treatment of acute Nipah encephalitis with ribavirin</title><author>Chong, Heng-Thay ; Kamarulzaman, Adeeba ; Tan, Chong-Tin ; Goh, Khean-Jin ; Thayaparan, Tarmizi ; Kunjapan, Sree Raman ; Chew, Nee-Kong ; Chua, Kaw-Bing ; Lam, Sai-Kit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3842-d4b422450ae1c7d4762dceb80b7f71db0602d3f106cf267829f6a58cc228fc443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Asian Continental Ancestry Group</topic><topic>Biological and medical sciences</topic><topic>China - ethnology</topic><topic>Encephalitis, Viral - drug therapy</topic><topic>Encephalitis, Viral - mortality</topic><topic>Encephalitis, Viral - physiopathology</topic><topic>Encephalitis, Viral - virology</topic><topic>Female</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Malaysia</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Paramyxovirinae - classification</topic><topic>Paramyxovirinae - isolation & purification</topic><topic>Paramyxovirinae - physiology</topic><topic>Pharmacology. 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| ispartof | Annals of neurology, 2001-06, Vol.49 (6), p.810-813 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Asian Continental Ancestry Group Biological and medical sciences China - ethnology Encephalitis, Viral - drug therapy Encephalitis, Viral - mortality Encephalitis, Viral - physiopathology Encephalitis, Viral - virology Female Human viral diseases Humans Infectious diseases Malaysia Male Medical sciences Paramyxovirinae - classification Paramyxovirinae - isolation & purification Paramyxovirinae - physiology Pharmacology. Drug treatments Retrospective Studies Ribavirin - adverse effects Ribavirin - therapeutic use Treatment Outcome Treatment Refusal Tropical medicine Viral diseases Viral diseases of the nervous system |
| title | Treatment of acute Nipah encephalitis with ribavirin |
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