Regulation by GDI of RhoA/Rho-kinase-induced Ca2+ sensitization of smooth muscle myosin II

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908 We characterized the role of guanine nucleotide dissociation inhibitor (GDI) in RhoA/Rho-kinase-mediated Ca 2+ sensitization of smooth muscle. Endogenous contents (~2-4 µM) of RhoA and...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2001-07, Vol.281 (1), p.C257-C269
Hauptverfasser:	Gong, Ming Cui, Gorenne, Isabelle, Read, Paul, Jia, Taiping, Nakamoto, Robert K, Somlyo, Avril V, Somlyo, Andrew P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Animals Calcium - metabolism Cell Membrane - metabolism Enzyme Inhibitors - pharmacology Escin - pharmacology Guanine Nucleotide Dissociation Inhibitors - genetics Guanine Nucleotide Dissociation Inhibitors - metabolism Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Ileum - cytology Ileum - metabolism In Vitro Techniques Intracellular Signaling Peptides and Proteins Muscle, Smooth - drug effects Muscle, Smooth - physiology Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Phenylephrine - pharmacology Portal Vein - cytology Portal Vein - metabolism Precipitin Tests Protein-Serine-Threonine Kinases - metabolism Pyridines - pharmacology Rabbits Recombinant Proteins - genetics Recombinant Proteins - metabolism rho-Associated Kinases rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism Urinary Bladder - anatomy & histology Urinary Bladder - chemistry Vasoconstrictor Agents - pharmacology Yeasts - genetics Yeasts - physiology
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